NANOSCIENCE – THEORY TO APPLICATION

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1 article(s) from Gao, Peiyang

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

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Figure 1: Structural conformations of PEG on lipid nanoparticle surfaces. At low PEG densities (D > 2R_PEG), t...

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Figure 2: Influence of PEG surface density on serum protein binding. The PEG surface density can be quantifie...

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Figure 3: Regular PEGylation density (<3% PEG mol %) retains some accessible LNP surface for protein and rece...

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Figure 4: Functionalized PEG lipids incorporated into LNPs to enable surface conjugation of diverse ligands f...

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Figure 5: Mechanism of anti-PEG immune response and ABC phenomenon. Initial dosing induces the splenic produc...

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Review

Published 30 Oct 2025

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