PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

• Paula M. Castillo,
• Mario de la Mata,
• Maria F. Casula,
• José A. Sánchez-Alcázar and
• Ana P. Zaderenko

Beilstein J. Nanotechnol. 2014, 5, 1312–1319, doi:10.3762/bjnano.5.144

• binding to DNA, CPT antitumor activity is due to inhibition of the nuclear enzyme topoisomerase I [4][5]. In spite of its potential as chemotherapeutic agent, CPT suffers from a reduced in vivo antitumor efficacy owing to its poor water-solubility and chemical instability (Figure 1). CPT-derivatives with