Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• survivin-small hairpin RNA (survivin-shRNA), which was trapped by electrostatic interactions in the cavity between several assembled nanoparticles (AP/ES+CQ NPs; AP = amine-terminated PAMAM dendrimers modified with anti-EGFR aptamer; ES = erlotinib and survivin-shRNA; Figure 2, Figure 3). The nanocomplexes

• siRNA delivery should generally be positively charged to facilitate siRNA loading by electrostatic interactions. Frequently used traditional polymer materials as nonviral vectors for siRNA encapsulation are polyethyleneimine (PEI), cationic dendrimers, phospholipids, cationic lipids, polysaccharides

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• nanoassemblies (green balls) were constructed through inclusion complex formation between trans-azobenzene and α-CyD (the second row from the top). These α-CyD-based nanoassemblies bind siRNA through electrostatic interactions with the positively charged N-methylimidazolium ions to form ternary supramolecular

LED-light-activated photocatalytic performance of metal-free carbon-modified hexagonal boron nitride towards degradation of methylene blue and phenol

• Nirmalendu S. Mishra and
• Pichiah Saravanan

Beilstein J. Nanotechnol. 2022, 13, 1380–1392, doi:10.3762/bjnano.13.114

•  7b. The high removal rate towards MB could be ascribed to a better adsorption boosted through electrostatic interactions (cationic MB and negatively charged surface of MBN-80) and the synergy obtained through the photoactivity of MBN-80 and dye sensitization through MB moieties. The

Laser-processed antiadhesive bionic combs for handling nanofibers inspired by nanostructures on the legs of cribellate spiders

• Sebastian Lifka,
• Kristóf Harsányi,
• Erich Baumgartner,
• Lukas Pichler,
• Dariya Baiko,
• Karsten Wasmuth,
• Johannes Heitz,
• Marco Meyer,
• Anna-Christin Joel,
• Jörn Bonse and
• Werner Baumgartner

Beilstein J. Nanotechnol. 2022, 13, 1268–1283, doi:10.3762/bjnano.13.105

• as electrostatic interactions. All these can be summarized in the term µ(x) and can, therefore, depend on the position and, thereby, on the distance of fiber and surface (w(x) − f(x)). However, only the van der Waals energy E3 exhibits a negative sign and, thus, decreases the total energy stored in

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

Design and selection of peptides to block the SARS-CoV-2 receptor binding domain by molecular docking

• Kendra Ramirez-Acosta,
• Ivan A. Rosales-Fuerte,
• J. Eduardo Perez-Sanchez,
• Alfredo Nuñez-Rivera,
• Josue Juarez and
• Ruben D. Cadena-Nava

Beilstein J. Nanotechnol. 2022, 13, 699–711, doi:10.3762/bjnano.13.62

• of the most commonly used programs [16][17][21]. ADV provides theoretical information about hydrophobic interactions, electrostatic interactions, hydrogen bonds, and van der Waals interactions. It can also predict the binding pose and binding affinity [20]. Considering these important features, ADV

Stimuli-responsive polypeptide nanogels for trypsin inhibition

• Petr Šálek,
• Jana Dvořáková,
• Sviatoslav Hladysh,
• Diana Oleshchuk,
• Ewa Pavlova,
• Jan Kučka and
• Vladimír Proks

Beilstein J. Nanotechnol. 2022, 13, 538–548, doi:10.3762/bjnano.13.45

• . Clearly, some fraction of 125I-radiolabeled BSA was again entrapped in the shrunken Nα-Lys-NG nanogel after the pH change (Figure 3a), probably due to high electrostatic interactions during the release at pH 7.4. After the loading and release procedure was optimized for BSA, PHEG-Tyr and Nα-Lys-NG

A comprehensive review on electrospun nanohybrid membranes for wastewater treatment

• Senuri Kumarage,
• Imalka Munaweera and
• Nilwala Kottegoda

Beilstein J. Nanotechnol. 2022, 13, 137–159, doi:10.3762/bjnano.13.10

• physisorption, only a reversible physical bond due to electrostatic interactions or intermolecular interactions forms between adsorbate and the adsorbent. An ideal adsorption membrane should exhibit both high adsorption capacity and a high adsorption rate. ENH membranes have been widely used as adsorption

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• , 5.6/1, 11.2/1, 22.4/1, and 45/1) which corresponds to SPION@bPEI to PIC w/w ratios of 0.5/1, 1/1, 2/1, 4/1, 8/1, and 16/1. In all these compositions, the amount of PIC was kept constant at 80 µg/mL (4 µg/well). The mechanism of loading of poly I:C on nanoparticles is through electrostatic interactions

Open-loop amplitude-modulation Kelvin probe force microscopy operated in single-pass PeakForce tapping mode

• Gheorghe Stan and
• Pradeep Namboodiri

Beilstein J. Nanotechnol. 2021, 12, 1115–1126, doi:10.3762/bjnano.12.83

• scale of the order of 20 μs, which is about one hundred times faster than CL KPFM modes and could be used to observe ultrafast dynamics of electrical processes [35][46]. Due to the long-range nature of the electrostatic interactions, contributions from all the conductive parts (apex, cone, and

• counterpart. The advantage of using OL AM-KPFM resides in the direct and easy implementation of the measurements with the possibility of accommodating relevant descriptions of the electrostatic interactions probed over various regions of a sample. Disclaimer Certain commercial equipment, instruments, or

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• by adsorption [92], with rates of release depending on interaction of the drug with the porous silicon. Oxidation, covalent binding, and electrostatic interactions can all be used to immobilise the drug on the porous silicon [94], while both hydrophilic and hydrophobic molecules can be loaded on

Modification of a SERS-active Ag surface to promote adsorption of charged analytes: effect of Cu²⁺ ions

• Bahdan V. Ranishenka,
• Andrei Yu. Panarin,
• Irina A. Chelnokova,
• Sergei N. Terekhov,
• Peter Mojzes and
• Vadim V. Shmanai

Beilstein J. Nanotechnol. 2021, 12, 902–912, doi:10.3762/bjnano.12.67

• nucleic acids are of great interest for practical SERS applications. Oligonucleotides are the most suitable biomolecules for electrostatic interaction studies because of their strong negative charge. Recently, we showed the crucial role of electrostatic interactions of oligonucleotides with NP surfaces

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Fate and transformation of silver nanoparticles in different biological conditions

• Barbara Pem,
• Marija Ćurlin,
• Darija Domazet Jurašin,
• Valerije Vrček,
• Rinea Barbir,
• Vedran Micek,
• Raluca M. Fratila,
• Jesus M. de la Fuente and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53

• of GSH was decreased in the case of PVP and AOT coating agents due to either unfavourable steric or electrostatic interactions, respectively. In both ALF and AGF, a significant agglomeration occurred for all three types of AgNPs. Moreover, a significant precipitation, visible in the test vials

• electrostatic interactions, respectively. In most tissue homogenates, AgNPs were well dispersed; however, the crystallization of AgNPs was observed in chloride-rich media resulting in the formation of large cubic and ball-like crystals as an indirect evidence of the formation of AgCl crystals and oxidative

Surface-enhanced Raman scattering of water in aqueous dispersions of silver nanoparticles

• Paulina Filipczak,
• Krzysztof Hałagan,
• Jacek Ulański and
• Marcin Kozanecki

Beilstein J. Nanotechnol. 2021, 12, 497–506, doi:10.3762/bjnano.12.40

• metal surfaces, which is very different in comparison to bulk water [24]. It was explained that the ordering of water molecules near to AgNPs is due to the electrostatic interactions between water and AgNPs. Some simulation studies also reported the enhancement of hydrogen bonds in the water structure

• it represents the relative slowdown of the solvent mobility induced by the presence of a fixed wall in relation to the solvent mobility in the bulk (determined for a solvent in a non-confined space). The simulation results show that even under athermal conditions (Eb = Ew – case without electrostatic

• interactions), the solvent mobility is lower near the surface in comparison to the bulk. The stronger the water interaction with the surface (in relation to water–water interactions in the bulk), the lower the solvent mobility close to the Ag surface. Moreover, this effect is not limited only to the first

Colloidal particle aggregation: mechanism of assembly studied via constructal theory modeling

• Scott C. Bukosky,
• Sukrith Dev,
• Monica S. Allen and
• Jeffery W. Allen

Beilstein J. Nanotechnol. 2021, 12, 413–423, doi:10.3762/bjnano.12.33

• natural coalescence, is decreased faster and more efficiently when the masses coalesce non-uniformly toward a state of equilibrium [10]. Similarly, Reis et al. used these principles to analyze how the electrostatic interactions between dust particles are minimized during particle agglomeration in air

Bulk chemical composition contrast from attractive forces in AFM force spectroscopy

• Dorothee Silbernagl,
• Media Ghasem Zadeh Khorasani,
• Natalia Cano Murillo,
• Anna Maria Elert and
• Heinz Sturm

Beilstein J. Nanotechnol. 2021, 12, 58–71, doi:10.3762/bjnano.12.5

• electrostatic interactions since the zero line, Figure 1(I), is stable up to distances of Z < −5 nm. Hence, as the main source of the measured attractive forces we consider electrodynamic interactions (caused by charge fluctuations in dipoles), commonly summarized under the term van der Waals forces. For the

Nanocasting synthesis of BiFeO₃ nanoparticles with enhanced visible-light photocatalytic activity

• Thomas Cadenbach,
• Maria J. Benitez,
• A. Lucia Morales,
• Cesar Costa Vera,
• Luis Lascano,
• Francisco Quiroz,
• Alexis Debut and
• Karla Vizuete

Beilstein J. Nanotechnol. 2020, 11, 1822–1833, doi:10.3762/bjnano.11.164

• catalyst surfaces are negatively charged, which leads to a repulsion of the negatively charged carboxylate functional groups of the dye molecule [51][54][59]. In addition, due to electrostatic interactions, RhB dimers are formed, which affects the charge density throughout the molecule and possibly leads

Gram-scale synthesis of splat-shaped Ag–TiO₂ nanocomposites for enhanced antimicrobial properties

• Mohammad Jaber,
• Asim Mushtaq,
• Kebiao Zhang,
• Jindan Wu,
• Dandan Luo,
• Zihan Yi,
• M. Zubair Iqbal and
• Xiangdong Kong

Beilstein J. Nanotechnol. 2020, 11, 1119–1125, doi:10.3762/bjnano.11.96

• TiO2 NP nucleation started after adding the urea and PVP surfactant. Then, the aqueously dispersed AgNO3 solution was poured into the prepared TiO2/PVP mixture. It was assumed that the positively charged Ag+ ions interacted with the negatively charged PVP-modified TiO2 NPs due to electrostatic

• interactions. In addition, the PVP also acted as a reducing agent and facilitated the formation of small Ag nanoparticles at the surface of the TiO2 spheres to form a splat-shaped structure (Scheme 1). PVP played a significant role in generating these nanocomposites, serving as a growth modifier, stabilizer

Adsorptive removal of bulky dye molecules from water with mesoporous polyaniline-derived carbon

• Hyung Jun An,
• Jong Min Park,
• Nazmul Abedin Khan and
• Sung Hwa Jhung

Beilstein J. Nanotechnol. 2020, 11, 597–605, doi:10.3762/bjnano.11.47

• adsorption of JGB showed an opposite trend. This very opposite trend, observed in anionic AR1 and cationic JGB, could be explained via electrostatic interactions considering the opposite charges on the studied dyes. Moreover, the studied PDC or KOH-900 might have both positive and negative charges, depending

Identification of physicochemical properties that modulate nanoparticle aggregation in blood

• Ludovica Soddu,
• Duong N. Trinh,
• Eimear Dunne,
• Dermot Kenny,
• Giorgia Bernardini,
• Ida Kokalari,
• Arianna Marucco,
• Marco P. Monopoli and
• Ivana Fenoglio

Beilstein J. Nanotechnol. 2020, 11, 550–567, doi:10.3762/bjnano.11.44

• interact with the proteins [22]. The affinity of a protein for a certain surface and the mode of interaction rise from the interplay of electrostatic interactions, hydrogen bondings, and hydrophobic forces [32]. Both nanomaterials are negatively charged at physiological pH. However, SNPs exhibit a less

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• manipulate the shell permeability [4]. However, most of the work uses strong PEs such as polystyrene sulfonate (PSS) as one of the polymers, and thus, in order to release the payload, a disturbance in the intermolecular forces (e.g., covalent binding, hydrogen bonding and electrostatic interactions) guarding

• various forces, mostly electrostatic interactions, hydrogen bonding, covalent bonding, host–guest interactions and other interactions (e.g., hydrophobic and biospecific recognition) as shown in Figure 3. Electrostatic interactions The LbL assemblies were originally applied to both charged planar

• formation and aggregation. This sequential adsorption of layers finally leads to electrostatically bound multilayers in which charge inversion is the main driving force controlling the assembly [40]. The strength and physical principles governing electrostatic interactions was recently explored by Lytle et

Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy

• Gayathri Kandasamy,
• Elena N. Danilovtseva,
• Vadim V. Annenkov and
• Uma Maheswari Krishnan

Beilstein J. Nanotechnol. 2020, 11, 354–369, doi:10.3762/bjnano.11.26

• differential thermal calorimetric profile (Figure 2B) reveals that the melting point of the pristine polymer is about 65 °C. Upon complexation with siRNA the melting point shifts to 98 °C. This can be attributed to the electrostatic interactions between the anionic phosphate moieties in the siRNA with the

• glycosaminoglycan associated with the inhibition of the coagulation process by activating anti-thrombin [23]. The sulfate groups present in heparin compete with the oligonucleotide sequences to associate with the polymer chains and based on the relative strength of the electrostatic interactions between the

Using gold nanoparticles to detect single-nucleotide polymorphisms: toward liquid biopsy

• María Sanromán Iglesias and
• Marek Grzelczak

Beilstein J. Nanotechnol. 2020, 11, 263–284, doi:10.3762/bjnano.11.20

• principle of this system rests on the fact that ssDNA exhibits a higher affinity to the surface of metallic gold as dsDNA. This is because ssDNA molecules contain a large number of functional groups facilitating electrostatic interactions with the gold surface (Figure 3c). Therefore, at a high salt

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• different from hydrophobic interactions have been proposed. For example, electrostatic interactions can improve the photosensitizer loading. Mostly amino acid-based polymers with poly(ʟ-lysine) [46][47] or poly(aspartic acid) [48][49] charged blocks have been employed for poly ion complex assemblies (PICs

• the formation of H aggregates between photosensitizer molecules, which hampers the production of singlet oxygen [50][51]. Hence, a careful choice of the hydrophobic block of the copolymer–photosensitizer couple for electrostatic interactions is needed. Interestingly, host–guest complexation of

• diameter and ζ-potential values switch from negative to positive thus accelerating cellular internalization [36]. Poly ion complexes formed thanks to electrostatic interactions between positively charged weak bases and negatively charged weak acids are ideal pH-responsive nanocarriers. PICs formed by