Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

• Jakub Hrib,
• Jakub Sirc,
• Radka Hobzova,
• Zuzana Hampejsova,
• Zuzana Bosakova,
• Marcela Munzarova and
• Jiri Michalek

Beilstein J. Nanotechnol. 2015, 6, 1939–1945, doi:10.3762/bjnano.6.198

• , Charles University in Prague, Albertov 2030, 128 43 Prague 2, Czech Republic Nanovia Ltd., Podkrusnohorska 271, 436 03 Litvinov-Chuderin, Czech Republic 10.3762/bjnano.6.198 Abstract Nanofibers were prepared from polycaprolactone, polylactide and polyvinyl alcohol using NanospiderTM technology

• implants [26]. In present work the PEGs were added to the solutions of polymers and were incorporated in nanofibers made from polycaprolactone (PCL), polylactide (PLA) and polyvinyl alcohol (PVA) during electrospinning. The release behavior of these molecules into the water environment was investigated and

• into aqueous media in which the solubility of such drugs are very low. Conclusion The release kinetics of polyethylene glycol molecules of various molecular weights from nanofibers prepared from polycaprolactone, polylactide and polyvinyl alcohol were assessed. The release rate and the total released

Oxygen-plasma-modified biomimetic nanofibrous scaffolds for enhanced compatibility of cardiovascular implants

• Anna Maria Pappa,
• Varvara Karagkiozaki,
• Silke Krol,
• Spyros Kassavetis,
• Dimitris Konstantinou,
• Charalampos Pitsalidis,
• Lazaros Tzounis,
• Nikos Pliatsikas and
• Stergios Logothetidis

Beilstein J. Nanotechnol. 2015, 6, 254–262, doi:10.3762/bjnano.6.24

• treatments [17]. Similarly, polycaprolactone (PCL) represents a commonly used biodegradable synthetic polymer for the fabrication of electrospun nanofibrous scaffolds [18], because of its beneficial bulk properties but lacks the proper surface environment for cellular attachment, mainly due to its strongly

• design and fabrication Materials and methods Polycaprolactone (PCL), Mn = 45,000 Da, chloroform (≥99.8%), methanol (≥99.9%) were obtained from Sigma (Sigma-Aldrich, Greece). All reagents were used without further purification and all solutions were prepared by deionised water. The nanofibrous scaffolds

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• -embedded polylactide-polycaprolactone (PLC–BNNT) in orthopedic implants [75]. Using real-time PCR methods, they studied the RunX2 gene expression profile, which is a transcription factor responsible for enhancing the cell proliferation. The results of the experiments showed that the PLC–BNNTs increased the

• biomaterials was investigated. In one study, the BNNTs were used in polylactide-polycaprolactone (PLC) copolymer as additives to improve the properties of the polymer as an orthopedic implant [75]. With the addition of BNNTs, a 1370% increase in the mechanical strength of the polymer was observed. The reason

Cyclodextrin-poly(ε-caprolactone) based nanoparticles able to complex phenolphthalein and adamantyl carboxylate

• Daniela Ailincai and
• Helmut Ritter

Beilstein J. Nanotechnol. 2014, 5, 651–657, doi:10.3762/bjnano.5.76

• N-isopropylacrylamide based copolymer have been reported [13]. The characterization and the morphology of a complex based on fish oil encapsulated in CD with the use of polycaprolactone have also been reported [14][15]. Furthermore, CD inclusion complexes with different essential oils and their

Improvement of the oxidation stability of cobalt nanoparticles

• Celin Dobbrow and
• Annette M. Schmidt

Beilstein J. Nanotechnol. 2012, 3, 75–81, doi:10.3762/bjnano.3.9

• , respectively. Cobalt nanoparticles with a brush-like shell of linear polycaprolactone (Co@PCL) were obtained by a ring-opening polymerization process of ε-caprolactone starting from ricinolic acid-capped cobalt [13]. Polystyrene coated particles (Co@PS) were accessed by replacing the fatty acid stabilizer

• an analogous investigation of oxidation kinetics. Polycaprolactone coated cobalt nanoparticles (Co@PCL) Co@PCL particles employed in this study were prepared according to a recently published method from ricinolic acid coated cobalt nanoparticles by surface-initiated ring-opening polymerization of CL

• [13][18][19]. This results in brush-like polymer shells. Co@PCL particle oxidation in air was investigated both with a toluene-based dispersion and with a powder sample (Figure 5). The magnetization graphs of the polycaprolactone coated particles in dispersion and as powder exposed to air show no