Pulmonary surfactant augments cytotoxicity of silica nanoparticles: Studies on an in vitro air–blood barrier model

• Jennifer Y. Kasper,
• Lisa Feiden,
• Maria I. Hermanns,
• Christoph Bantz,
• Michael Maskos,
• Ronald E. Unger and
• C. James Kirkpatrick

Beilstein J. Nanotechnol. 2015, 6, 517–528, doi:10.3762/bjnano.6.54

• Abstract The air–blood barrier is a very thin membrane of about 2.2 µm thickness and therefore represents an ideal portal of entry for nanoparticles to be used therapeutically in a regenerative medicine strategy. Until now, numerous studies using cellular airway models have been conducted in vitro in order

• cytotoxicity of aSNP-surfactant interaction on cell cultures kept on the air–liquid interface (ALI). On ALI the epithelial cells develop a physiological surfactant monolayer as it occurs in vivo. Prospectively, the results are relevant for the field of regenerative medicine, in which nanoparticles could be

Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation

• Ivonne Brüstle,
• Thomas Simmet,
• Gerd Ulrich Nienhaus,
• Katharina Landfester and
• Volker Mailänder

Beilstein J. Nanotechnol. 2015, 6, 383–395, doi:10.3762/bjnano.6.38

• great interest for tissue engineering approaches (e.g., for defects of bone or cartilage). Over 100 clinical trials employing hMSCs for regenerative medicine, for instance, after stroke and myocardial infarction [17], demonstrate that the clinical use of these cells is of utmost interest. Therefore, the

Oxygen-plasma-modified biomimetic nanofibrous scaffolds for enhanced compatibility of cardiovascular implants

• Anna Maria Pappa,
• Varvara Karagkiozaki,
• Silke Krol,
• Spyros Kassavetis,
• Dimitris Konstantinou,
• Charalampos Pitsalidis,
• Lazaros Tzounis,
• Nikos Pliatsikas and
• Stergios Logothetidis

Beilstein J. Nanotechnol. 2015, 6, 254–262, doi:10.3762/bjnano.6.24

• treatment conditions are the most appropriate for enhancing the surface functionality without affecting the morphological properties and chemical structure of the polymer. Mechanical behavior of the plasma-treated scaffolds A basic principle in regenerative medicine is to maintain the structural integrity

Formation of stable Si–O–C submonolayers on hydrogen-terminated silicon(111) under low-temperature conditions

• Yit Lung Khung,
• Siti Hawa Ngalim,
• Andrea Scaccabarozzi and
• Dario Narducci

Beilstein J. Nanotechnol. 2015, 6, 19–26, doi:10.3762/bjnano.6.3

• Yit Lung Khung Siti Hawa Ngalim Andrea Scaccabarozzi Dario Narducci University of Milan-Bicocca, Department of Materials Science, Via R. Cozzi 53, I-20125 Milan, Italy Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Penang, Malaysia 10.3762

Imaging the intracellular degradation of biodegradable polymer nanoparticles

• Anne-Kathrin Barthel,
• Martin Dass,
• Melanie Dröge,
• Jens-Michael Cramer,
• Daniela Baumann,
• Markus Urban,
• Katharina Landfester,
• Volker Mailänder and
• Ingo Lieberwirth

Beilstein J. Nanotechnol. 2014, 5, 1905–1917, doi:10.3762/bjnano.5.201

• cells (MSCs) were chosen because they are promising candidates for regenerative medicine [18][19] and they show a moderate cleavage rate without addition of transfection agents or mitotic inhibitors [20][21]. Common strategies to monitor and quantify the nanoparticle load on a single cell level are