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Search for "skin" in Full Text gives 182 result(s) in Beilstein Journal of Nanotechnology.
Direct electron beam writing of silver using a β-diketonate precursor: first insights
Beilstein J. Nanotechnol. 2024, 15, 1117–1124, doi:10.3762/bjnano.15.90
- challenges in device design and fabrication. Accordingly, various methods to improve purity during [15][16][17][18] or after deposition [18][19][20][21][22] were developed. For plasmonic applications, a metallic surface layer with a thickness exceeding the skin depth is sufficient to obtain the desired
- functionality [23][24]. Here, skin depth refers to the penetration depth of an electromagnetic field into a (non-transparent) metallic material. While pure metal deposition by direct electron beam writing was demonstrated for gold precursors with inorganic ligands [25][26], high purity comes often at the
Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications
Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88
The effect of age on the attachment ability of stick insects (Phasmatodea)
Beilstein J. Nanotechnol. 2024, 15, 867–883, doi:10.3762/bjnano.15.72
- , damage, contaminations, and changes of material properties of the integument of the attachment pads. Geckos, however, continuously shed their skin throughout their life, in contrast to insects; this was shown to enable regeneration of the adhesive properties of the attachment system to some extent [62
Investigation on drag reduction on rotating blade surfaces with microtextures
Beilstein J. Nanotechnol. 2024, 15, 833–853, doi:10.3762/bjnano.15.70
- moving animals, such as the “denticles” found on the surface of shark skin, which enable high-speed swimming [2], as well as the texture of bird feathers [3]. The phenomenon of drag reduction can also be observed on the surface of plants. For example, there is a superhydrophobic structure on the surface
- ]. Lang et al. [8] constructed rectangular and sinusoidal grooves with 2 mm in width, 3 mm in depth, and 1 mm in spacing, thus mimicking the transverse grooves on the surface of dolphin skin. They observed the effect of the grooves on flow separation and boundary layer using digital particle image
- better than that of the other two structures. Tian et al. [10] pointed out that, because of the complexity of microstructures on the shark skin surface, it is difficult to use a uniform method to characterize the skin surface. Triangular grooves or rectangular grooves can be used to simplify the
When nanomedicines meet tropical diseases
Beilstein J. Nanotechnol. 2024, 15, 830–832, doi:10.3762/bjnano.15.69
- Eder Lilia Romero Katrien Van Bocxlaer Fabio Rocha Formiga Nanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, B1876 Bernal, Provincia de Buenos Aires, Argentina Skin Research Centre, Hull York Medical School
Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material
Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65
- 8 h; however, only 50% of the zinc acetate was dissolved. In addition, antibacterial activity tests were performed with four different bacterial strains relevant to skin surface injuries, leading to the appearance of inhibition zones around the scaffold discs in most cases. We also investigated the
- 24 h of incubation. The msalt is the calculated mass of the salts in a scaffold disc (6 mm in diameter). In vitro cell studies Cell cultures An osteosarcoma cell line (MG-63, ECACC 86051601) and skin fibroblasts (155BR, ECACC 90011809), both of human origin, were cultured as monolayers at 37 °C and 5
- , including strength and elasticity of the fibrous scaffold, are crucial parameters. Medical gauze has a storage modulus of 1 MPa to 1 GPa [58], while the Young’s modulus of the skin is between 0.1 and 10 kPa, depending on the body parts, layer, and skin age [59]. In our research, we aimed to investigate the
Functional fibrillar interfaces: Biological hair as inspiration across scales
Beilstein J. Nanotechnol. 2024, 15, 664–677, doi:10.3762/bjnano.15.55
- square centimeter) [32]. Hairs on humans have also been reported to protect the skin from UVA and UVB radiation from the sun [33]. UV radiation from the sun can not only heat up human skin but is also linked to skin cancers. Therefore, in mammals and birds, hairs provide protection from thermal effects
- [21][22]. Burrowing The use of hairs to generate frictional forces is not unique to animals that climb. Hair-like setae on the skin of earthworms aid in burrowing by increasing friction and providing anisotropic anchoring [65][66][67]. When burrowing, the earthworm mainly uses cavity expansion to
Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy
Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49
- significant side effects such as hypertension, proteinuria, and skin toxicity [7][8]. Hence, there is a pressing need to develop new therapeutic modalities that offer substantial efficacy while minimizing side effects. Extensive efforts have been dedicated to drug development and delivery technologies in
Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent
Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46
- metalloproteases substrate (FS-6), Sephadex G-50, lipopolysaccharides from Escherichia coli 0111:B4 (LPS), Mitochondria Staining Kit (JC-1 dye), valinomycin, sodium dodecyl sulfate (SDS), dexamethasone (DEX), ammonium persulfate, phorbol 12-myristate 13-acetate (PMA), gelatin from bovine skin type B, and BSA
- normal deliveries with written informed consent from the mother. HUVECs were purified from the human umbilical vein by digestion with collagenase (Gibco, Grand Island, NY, USA) [78]. Cells were grown in plate coated with 2% gelatin from bovine skin type B in EGM-2 supplemented with antibiotics (100 U/mL
- Figure 13. Briefly, HUVECs were seeded in EGM-2 medium at a density of 4 × 104/cm2 on ThinCert™ cell culture inserts (12 wells, 0.4 µm pore size PET membrane Greiner Bio-One GmbH, Austria) previously covered with 2% bovine skin gelatin type B and grown for 24 h. Also, 10.5 × 104/cm2 THP-1 macrophages per
Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems
Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42
- ) and enteric formulation. In this study, DCS nanocrystals were fabricated and investigated for novel drug delivery systems. Transdermal drug delivery is an administration route wherein the API is delivered across the skin for systemic distribution. The categories of TDD systems include reservoir
- vascular endothelial cells are at low frequency, and that the trans-endothelial pathways are the dominant mechanisms for nanoparticle extravasation in tumors (also called enhanced permeability and retention (EPR) effect) [37]. Since the skin has a denser structure than that of tumor vessels, we speculated
- that a driving force similar to the EPR effect might be one of the forces driving DCS nanocrystals to penetrate the skin layer. The findings above implied that DCS nanocrystals had a much better penetration capability through human skin and could be applied for transdermal drug delivery due to their
Classification and application of metal-based nanoantioxidants in medicine and healthcare
Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36
- ) concentration of 0.5 wt % for the successful formation of ferulic acid-loaded lipid-based nanoparticles [141]. The ferulic acid-loaded nanoparticles with improved bioavailability can be useful for skin care products and human skin cancer treatment [142][143][144]. Wound repair The skin is the outermost layer
- , the largest organ, and the first barrier protecting our body against toxic elements, infections, and dehydration, which makes it vulnerable. A major skin injury can cause severe problems to human health such as increased risk of infections, dehydration, and immune system disorders [145][146]. Wound
- repair is a crucial process for the recovery of injured skin by which the integrity of the wounded area is restored and regenerated. In wound repair, ROS acts as a double-edged sword because ROS have both positive and negative effects on wound repair. At a low ROS level, the wound repair process benefits
Nanomedicines against Chagas disease: a critical review
Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30
- idiosyncratic adverse drug reactions (ADRs), caused by BNZ reduction products, which are maximal in adults and lead to treatment discontinuation [19]. Typical ADRs include headache, anorexia, weakness and/or lack of energy, skin rash, gastrointestinal complaints, and mild, peripheral neurological effects [20
Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors
Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27
- different areas [1]. However, the innovation of nanomaterials (NMs) is hindered because of potential adverse effects. It is believed that small particles can enter the body through inhalation, ingestion, and skin penetration and have the potency to interact with macromolecules for a long period. Many
Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review
Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4
- areas of the skin, or diffuse when several lesions occur over an extensive area of skin tissue [3]; (ii) mucocutaneous leishmaniasis, which causes total or partial degeneration of the mucous membranes of the nose, mouth, and throat [4], and (iii) visceral leishmaniasis (also known as kala-azar), can
- in female Balb/c mice [72]. The results of the study showed an improvement in skin lesions of groups treated with Ag-NP both before and after infection. The group treated after infection displayed a significant decrease in lesion size starting in the second week of treatment, with complete healing
- , respectively. Additionally, this nanosystem proved to be biocompatible with skin fibroblasts (in vitro). However, neither the cell viability of this system in healthy macrophages nor models of parasite infection in this cell type were evaluated. Considering that the nanoscale platform approved by the FDA and
Nanotechnological approaches in the treatment of schistosomiasis: an overview
Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2
- ]. Every year, 200 thousand deaths are caused by schistosomiasis, making it the third most devastating tropical disease in the world after malaria and intestinal parasitosis [3]. After penetration of the skin by the larval form (cercariae), the schistosomes mature and migrate through the lung to the liver
- unsaturated free fatty acid in the outer layer of human skin, is commonly used as a permeation promoter, inducing the disruption of the lipid structure of the membrane. de Oliveira et al. [85] showed in vitro that oleic acid encapsulated in polymeric nanoparticles could potentially be used in schistosomiasis
Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells
Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100
- , France UMR 7199, CNRS/University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France CNRS, 23 rue du Loess, 67200 Strasbourg, France 10.3762/bjnano.14.100 Abstract Inspired by the eumelanin aggregates in human skin, polydopamine nanoparticles (PDA NPs) are promising nanovectors for biomedical
- bacteria. Inspired by the eumelanin aggregates in human skin, polydopamine nanoaggregates (here referred to as nanoparticles, i.e., PDA NPs) have emerged as promising nanovectors for biomedical applications [11][12], especially because of their biocompatibility [13][14] and photothermic properties [15][16
Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems
Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95
- barriers besides cellular membranes need to be addressed. A few examples of these barriers are penetration in or permeation through mucus, skin penetration, overcoming the blood brain barrier, or extravasation from blood vessels. Another challenge is the accumulation of particulate drug delivery systems in
Exploring internal structures and properties of terpolymer fibers via real-space characterizations
Beilstein J. Nanotechnol. 2023, 14, 1004–1017, doi:10.3762/bjnano.14.83
- apparent skin–core differentiation in the microstructure (e.g., as in Kevlar®) is observed [11][13][14][15][16]. The lack of evidence for a skin–core structure in Technora® was referenced in an earlier study by Derombise et al. [17], but to our knowledge, this is the first time this has been directly shown
- explains how the complex nanostructure translates up to the microstructure, leading to more disorder in 3D space in Technora® compared to Kevlar®. The other unique microstructural aspect is the lack of a fiber skin in our real-space AFM scans of Technora®. In Kevlar®, the skin is a prominent feature up to
- treatments possess thinner skins [11][13][15]. In previous studies, we corroborated this trend for different classes of Kevlar® fibers using real-space AFM scans, as skin regions contained distinct topographical features and lower stiffness than the Kevlar® fiber core [11][13]. For Technora®, however, no
Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics
Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75
- active targeting via the functionalization of ligands, such as antibodies or proteins, that interact with receptors overexpressed at the target site [5][6]. However, the movement of NPs is hampered by biological barriers such as endothelial, cellular, skin, and mucosal barriers, which obstruct their
Industrial perspectives for personalized microneedles
Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70
- Australian company Vaxxas. Pty. Ltd. Vaxxas has developed a non-dissolving microneedle patch, called the Nanopatch [13][14][15]. In the Nanopatch, the microneedles are coated in a dry vaccine powder, and upon insertion, the microneedles leave pores in the skin where the powder particles can be bioabsorbed
- , it is crucial to consider that structural skin properties (e.g., transepidermal water loss, skin elasticity, dermal layer thicknesses, and ceramide content) differ among these groups [16][17][18], or else results give an incomplete picture. Several studies have also reported that the various
- demographic groups (e.g., ethnicity and age) heal at different rates [16][19]. Therefore, it is also critical to consider differences in skin penetration, drug absorption, and healing processes among different populations when assessing the effectiveness of drug-delivering microneedles. In today's age of
A wearable nanoscale heart sound sensor based on P(VDF-TrFE)/ZnO/GR and its application in cardiac disease detection
Beilstein J. Nanotechnol. 2023, 14, 819–833, doi:10.3762/bjnano.14.67
- a series of processing steps, the heart sound signal is obtained. However, PZT has a brittle texture, does not fit the skin well, and lacks comfort when worn, making it unsuitable for wearable sensors [10]. Moreover, the lead in PZT is harmful to humans. In recent years, there has been a significant
- sensor after bending. It was observed that the sensor encapsulated by silica gel was highly flexible and could fit snugly onto the skin. Additionally, the food-grade silica gel used in the outermost layer is ecologically friendly, harmless to human health, and makes for a great wearable, flexible
- piezoelectric nanoscale heart sensor, and the outermost layer of silica gel effectively protected the flexible nanofilm and adhered to the skin. In this paper, the acoustic-electric conversion performance of P(VDF-TrFE)/ZnO/GR piezoelectric composite films was evaluated using a self-built acoustic-electric
Microneedle patches – the future of drug delivery and vaccination?
Beilstein J. Nanotechnol. 2023, 14, 494–495, doi:10.3762/bjnano.14.40
- blood for diagnostic tests. Other tests, such as blood glucose monitoring in diabetics [1], release blood by a pinprick from the capillaries immediately beneath the skin. Microneedles (MNs), typically less than 1 mm long, are a late 20th century development with significant promise for the above
- MNs tailored to penetrate the skin and provide access to blood capillaries or the ISF have been the subject of a rapidly growing number of research publications over the last decade, and the trend continues [7]. Several key issues discussed in these papers are also considered in this thematic issue [8
- ][9]. Recent progress may be broadly categorised as MN design, fabrication, skin penetration studies, and applications, ranging from drug delivery and vaccination to diagnostics. The first two of these have received most attention, but considerable work is still to be done in all categories – more in
Plasmonic nanotechnology for photothermal applications – an evaluation
Beilstein J. Nanotechnol. 2023, 14, 380–419, doi:10.3762/bjnano.14.33
Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles
Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28
- . Lee et al. recorded similar observations after examining the leakiness of human skin microvascular endothelial cells (HMVECs) after exposure to citrate-stabilized Au NPs of different sizes and concentrations. Using in vitro, ex vivo, and in silico studies, they confirmed the interaction mechanism of
Recent progress in cancer cell membrane-based nanoparticles for biomedical applications
Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24
- system diseases Cancer cell membrane-based NPs play a unique therapeutic role in immune system diseases due to their immunomodulatory functions. Systemic lupus erythematosus (SLE) is an incurable chronic autoimmune disease that involves multiorgan damage (e.g., to the skin, joints, kidneys, heart, and
- containing biomimetic NPs with the HCT116 cell membrane was developed for the treatment of colon cancer [45]. Through simple skin delivery and the subsequent presentation of relevant antigens, it can endow the body with efficient antitumor immunity [45]. Moreover, the nanovaccine integrated with
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