Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• 587 and 1620 cm−1 are indicative of Fe3O4 NPs. These results are in line with a study by Xue and co-workers [45]. The broad absorption bands in the 1700–1000 cm−1 range suggest the presence of aromatic rings and phenolic compounds in PDA. These bands demonstrate the effective coating with PDA, as

Design, fabrication, and characterization of kinetic-inductive force sensors for scanning probe applications

• August K. Roos,
• Ermes Scarano,
• Elisabet K. Arvidsson,
• Erik Holmgren and
• David B. Haviland

Beilstein J. Nanotechnol. 2024, 15, 242–255, doi:10.3762/bjnano.15.23

• with 600 nm low-stress (<100 MPa) Si-N films. The sensor chips are 1.6 mm by 3.4 mm, about the size of a standard AFM cantilever chip. The steps are as follows: (a) Superconducting film. We first deposit a 15 nm thick thin film of superconducting Nb60Ti40N by reactive co-sputtering from separate

Multiscale modelling of biomolecular corona formation on metallic surfaces

• Parinaz Mosaddeghi Amini,
• Ian Rouse,
• Julia Subbotina and
• Vladimir Lobaskin

Beilstein J. Nanotechnol. 2024, 15, 215–229, doi:10.3762/bjnano.15.21

• the CoronaKMC software. First, we implemented a method to accelerate the simulation by adjusting rate constants for quasi-equilibriated processes (e.g., the adsorption of lactose) according to the methodology of Dybeck and co-workers [47]. Second, we added an optional mode in which the acceptance

Exploring disorder correlations in superconducting systems: spectroscopic insights and matrix element effects

• Vyacheslav D. Neverov,
• Alexander E. Lukyanov,
• Andrey V. Krasavin,
• Alexei Vagov,
• Boris G. Lvov and
• Mihail D. Croitoru

Beilstein J. Nanotechnol. 2024, 15, 199–206, doi:10.3762/bjnano.15.19

• work of Neverov and co-workers [49]. This study has unveiled a significant influence of these correlations on the superconductive characteristics at the zero-temperature limit, where thermal energy represents the smallest energy scale within the investigated system. Specifically, the research has

Graphene removal by water-assisted focused electron-beam-induced etching – unveiling the dose and dwell time impact on the etch profile and topographical changes in SiO₂ substrates

• Aleksandra Szkudlarek,
• Jan M. Michalik,
• Inés Serrano-Esparza,
• Zdeněk Nováček,
• Veronika Novotná,
• Piotr Ozga,
• Czesław Kapusta and
• José María De Teresa

Beilstein J. Nanotechnol. 2024, 15, 190–198, doi:10.3762/bjnano.15.18

• as an unwanted co-deposition of amorphous carbon. Those deposition and etching processes may co-exist and can be controlled to a certain level by the electron flux [23]. The influence of surface kinetics phenomena on the etch profiles has not been considered in the previous works describing the proof

• [17]. The central protrusion in the etch profiles is observed in ex situ AFM profiles at high doses in case of singular lines and large triangular patterns. Its origin is unlikely due to amorphous carbon co-deposition from the residual vapor impurities. Such transition from the deposition (FEBID) of

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• nanocarrier that can be loaded with the chemotherapeutic medication chlorambucil and magnetic resonance imaging agents (e.g., iron oxide nanoparticles and near-infrared fluorophore IR780) for theragnostics. Poly(lactic-co-glycolic acid) was combined with the aforementioned ingredients to generate poly(vinyl

• delivery system. The delivery system is comprised of three components: the carrier, the imaging agent, and the therapeutic drug, all of which need clinical approval before being used in humans. Poly(lactic-co-glycolic acid) (PLGA) is an approved biodegradable and biocompatible material for clinical use [1

• diagnoses, including tumor-targeted drug delivery, hyperthermia, photodynamic therapy, and imaging. Nanomedicines can be made from a variety of inert, biodegradable, and in vivo biocompatible materials. Poly(lactic-co-glycolic acid) is one of the most biodegradable and biocompatible copolymers owing to its

Modification of graphene oxide and its effect on properties of natural rubber/graphene oxide nanocomposites

• Nghiem Thi Thuong,
• Le Dinh Quang,
• Vu Quoc Cuong,
• Cao Hong Ha,
• Nguyen Ba Lam and
• Seiichi Kawahara

Beilstein J. Nanotechnol. 2024, 15, 168–179, doi:10.3762/bjnano.15.16

• Nghiem Thi Thuong Le Dinh Quang Vu Quoc Cuong Cao Hong Ha Nguyen Ba Lam Seiichi Kawahara School of Chemical Engineering, Hanoi University of Science and Technology, No 1 Dai co Viet, Hanoi, Vietnam Faculty of Engineering, Nagaoka University of Technology, 1603-1, Kamitomioka-machi, Nagaoka

CdSe/ZnS quantum dots as a booster in the active layer of distributed ternary organic photovoltaics

• Gabriela Lewińska,
• Piotr Jeleń,
• Zofia Kucia,
• Maciej Sitarz,
• Łukasz Walczak,
• Bartłomiej Szafraniak,
• Jerzy Sanetra and
• Konstanty W. Marszalek

Beilstein J. Nanotechnol. 2024, 15, 144–156, doi:10.3762/bjnano.15.14

• publication aims to validate the potential of CdSe/ZnS quantum dots for the enrichment of the active layer and, ultimately, for application in the active layer of organic BHJ cells. An illustrative QD synthesis was described by Dabbousi and co-workers [38]. Methods and approaches were intensively developed

• :P3HT:PC71BM are characterized by significantly lower resistance compared to P3HT:PC71BM, which may be responsible for the higher ionic or electronic conductivity of these layers. A similar effect was reported by Zhao et al. and Zang and co-workers [55][56]. Simulations and analyses of ternary OPVs The energy

• recombination, and increased charge transport. This was also demonstrated by Lv and co-workers [65]. The LUMO level of QD600 is lower than that of the donor P3HT, while the other QDs have higher LUMO levels. This difference in LUMO levels poses a challenge for the transportation of electrons to the cathode

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• -Dimethylformamide (≥99.5%) and dichloromethane (>98%) were supplied by Xilong Scientific Co., Ltd., China. Berberine chloride powder (purity > 99%, pharmaceutical primary standard) was commercially obtained from Sigma-Aldrich, Singapore. Nutrient broths were provided by Titan Biotech, India. Bi-distilled water was

Influence of conductive carbon and MnCo₂O₄ on morphological and electrical properties of hydrogels for electrochemical energy conversion

• Sylwia Pawłowska,
• Karolina Cysewska,
• Yasamin Ziai,
• Jakub Karczewski,
• Piotr Jasiński and
• Sebastian Molin

Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6

• )porphyrin hydrogel) and PPy/FeTCPP/Co catalyst at 10 mA/cm2 current density, and in 0.1 M KOH, were 1.74 and 1.61 versus RHE, respectively (the catalyst loading equals to 0.3 mg/cm2) [55]. The analysis of , , and hydrogel catalysts in 1 M KOH for the OER process showed that the overpotential at a current

• /FeTCPP and PPy/FeTCPP/Co samples (74 mV/dec and 65 mV/dec, respectively), they are very similar [55], and much better than the results obtained for NF-NiCo (614 mV/dec) [34]. For transition-metal-functionalised polyaniline-phytic acid hydrogels, Tang et al. obtained Tafel slopes in the range of 78–191 mV

• conductive carbon black concentrations in hydrogel composite samples (c). Analysis of electrical properties of hydrogel-based samples with catalyst (M CO) and conductive (cCB) particles (experimental data (dot line) and Randles model results (solid line)): a) Bode modulus and b) phase angle with fitting

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• systems made of an isotropic blend of oils, surfactants, and co-surfactants or co-solvents [76]. These spontaneously form O/W nanoemulsions (≤200 nm) in aqueous media (generally in a physiological media) [77][78]. The SNEDDSs have been successfully used to carry molecules with biopharmaceutical

• able to kill the intracellular amastigotes in macrophages. Moreover, the authors developed a further study wherein seven nanoformulations with different mixtures of oils, surfactants, and co-surfactants were reported [48]. The obtained SNEDDSs showed droplet size between 30–80 nm and IC50 values of

• system and consequently the intracellular leishmanicidal activity [50][105]. Poly(lactic-co-glycolic) acid (PLGA) is another polymer used for the development of nanoparticles for the treatment of leishmaniasis [107][108]. PLGA is an FDA-approved polymer that is commonly used in the synthesis of

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• established criteria were identified. Inorganic and polymeric nanoparticles were the most prevalent nanosystems used. Gold was the primary material used to produce inorganic nanoparticles, while poly(lactic-co-glycolic acid) and chitosan were commonly used to produce polymeric nanoparticles. None of these

• , an exponential drug release [17][20]. Our research found that many articles utilized poly(lactic-co-glycolic acid) (PLGA) and chitosan nanoparticles, especially because they are biocompatible polymers and present great biodegradability. The polymer PLGA is approved for clinical use by Food and Drug

TEM sample preparation of lithographically patterned permalloy nanostructures on silicon nitride membranes

• Joshua Williams,
• Michael I. Faley,
• Joseph Vimal Vas,
• Peng-Han Lu and
• Rafal E. Dunin-Borkowski

Beilstein J. Nanotechnol. 2024, 15, 1–12, doi:10.3762/bjnano.15.1

• or volatile particles, which can be pumped out. RIE of nickel–iron alloys has been carried out using inductively coupled plasma RIE with argon and chlorine [34] or with NH3 and CO [35]. Stencil lithography requires further optimization although possible applications are attractive because of the

unDrift: A versatile software for fast offline SPM image drift correction

• Tobias Dickbreder,
• Franziska Sabath,
• Lukas Höltkemeier,
• Ralf Bechstein and
• Angelika Kühnle

Beilstein J. Nanotechnol. 2023, 14, 1225–1237, doi:10.3762/bjnano.14.101

• stationary features, however, we find that algorithm II works with remarkable reliability. In contrast to algorithm II, algorithm III does not evaluate the mean shift between images but the apparent shift of single stationary features as described by Rahe and co-workers [5]. It is necessary to subsequently

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells

• Eloïse Equy,
• Jordana Hirtzel,
• Sophie Hellé,
• Béatrice Heurtault,
• Eric Mathieu,
• Morgane Rabineau,
• Vincent Ball and
• Lydie Ploux

Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100

• ) of poly(lactic-co-glycolic acid) (PLGA) [7], polycaprolactone [8], and chitosan [9]. Furthermore, fluorescent ONPs are a promising way to facilitate the localization of NPs in cells through fluorescence imaging. They can also be used for fluorescent labelling of cells, especially for live cell

• mixtures of BSA and DA in Tris buffer inhibited the deposition of a PDA film on the wall of the reaction beakers (Figure 3a). This suggested that BSA/PDA aggregates formed and that almost all the free DA molecules were consumed in these aggregates, as already mentioned by Bergtold and co-workers [13]. A

• ratio of 3 and 60% for a BSA/DA ratio of 10. The smallest BSA/PDA NPs had a mean diameter of 9 nm in 50 mM Tris and of 10 nm in H2O, but of 18 nm in 150 mM NaCl solution (Figure 3d). This increase was attributed to two co-existing phenomena related to the high salt concentration in 150 mM NaCl. First

A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH₃)₂Cl]₂

• Elif Bilgilisoy,
• Ali Kamali,
• Thomas Xaver Gentner,
• Gerd Ballmann,
• Sjoerd Harder,
• Hans-Peter Steinrück,
• Hubertus Marbach and
• Oddur Ingólfsson

Beilstein J. Nanotechnol. 2023, 14, 1178–1199, doi:10.3762/bjnano.14.98

• . This may partly explain the insufficient metal content achieved when using CVD precursors in FEBID [18]. In this context, efforts have been made to design gold precursors optimized for FEBID. Arguably, the most noticeable of these are chloro(carbonyl)gold(I) (AuICl(CO)) [22] and chloro

• of magnitude for DI and DEA of the FEBID precursor Co(CO)3(NO) [49][50] and Pt(PF3)4 [51], the reactive area of this monolayer is 0.15 μm2. Statistically, this implies approx. 300 reactive incidents per molecule if the cross section is assumed to stay unchanged. This is clearly not a quantitative

• , and studies on the gold(I) precursors AuXL (L = P(NMe2)3, PMe3, CNMe, CNt-Bu, P(OCH2CF3)3; X = Cl, Br, I) [52], and on Ru(CO)4I2 [31], Ru(η3-C3H5)(CO)3X (X = Cl, Br) [48][53][54], Pt(NH3)2Cl2 [55][56], and Pt(CO)2X2 (X = Cl, Br) [57][58][59][60][61] have been reported. These include post-deposition

Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment

• Lester Uy Vinzons,
• Guo-Chung Dong and
• Shu-Ping Lin

Beilstein J. Nanotechnol. 2023, 14, 1157–1168, doi:10.3762/bjnano.14.96

• ], poly(lactic-co-glycolic acid) nanodots enhanced the proliferation and neurite sprouting of Neuro-2a cells [7], and oriented elliptical Si microcones induced alignment and increased fasciculation in rat superior cervical ganglion axons [8]. With their effects complementing those of continuous structures

• Advanced Materials (MA, USA), while AZ1518 and AZ 300 MIF developer were purchased from MicroChemicals GmbH (Germany). PDMS, γ-butyrolactone (GBL), and PU pellets (Tecothane®, clear; TT-1085A) were obtained from Sil-More Industrial Ltd. (Taiwan), Echo Chemical Co., Ltd. (Taiwan), and Lubrizol Advanced

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• filled with poly(lactic-co-glycolic acid) (PLGA) cores of different sizes resulting in interfacial water layers with different thicknesses and therefore with tunable elasticity [38]. Semielastic particles whose Young’s moduli were around 50 mPa showed the fastest diffusion in mucus. However, harder

A multi-resistance wide-range calibration sample for conductive probe atomic force microscopy measurements

• François Piquemal,
• Khaled Kaja,
• Pascal Chrétien,
• José Morán-Meza,
• Frédéric Houzé,
• Christian Ulysse and
• Abdelmounaim Harouri

Beilstein J. Nanotechnol. 2023, 14, 1141–1148, doi:10.3762/bjnano.14.94

• 20IND12), which is supported by the European Metrology Programme for Innovation and Research (EMPIR). The EMPIR initiative is co-funded by the European Horizon 2020 research and innovation program and the EMPIR Participating States. Competing Interests The authors declare no competing interests.

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• poorly water-soluble CUR. An effective submicron particle fabrication technique, namely co-precipitation–cross-linking–dissolution (CCD), has been established to produce biopolymer particles [24][25][26]. In this method, biopolymer particles are produced via co-precipitation, by simply mixing MnCl2 and

• particles are easily synthesized via cost-effective co-precipitation methods. These techniques are simple, low-cost, and easily scalable, enabling precise control over particle characteristics, including size and morphology, and use inexpensive materials without generating toxic waste. Having established an

• (CUR-HSA-MPs) is shown in Figure 1. At first, MnCO3-HSA-MPs were obtained by co-precipitation for the entrapment of HSA. The entrapment efficiency (%EE) of HSA was between 55% and 62% (i.e., the absolute amounts of entrapped HSA in HSA-MPs were up to 31.3 ± 1.8 mg). CUR was then adsorbed onto the MnCO3

A bifunctional superconducting cell as flux qubit and neuron

• Dmitrii S. Pashin,
• Pavel V. Pikunov,
• Marina V. Bastrakova,
• Andrey E. Schegolev,
• Nikolay V. Klenov and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2023, 14, 1116–1126, doi:10.3762/bjnano.14.92

• , Russia 10.3762/bjnano.14.92 Abstract Josephson digital or analog ancillary circuits are an essential part of a large number of modern quantum processors. The natural candidate for the basis of tuning, coupling, and neromorphic co-processing elements for processors based on flux qubits is the adiabatic

• millikelvin temperatures with zeptojoule energy efficiency [11][12][13][14][15][16][17]. In addition, the basic cells of adiabatic superconducting circuits can be used as a part of neuromorphic co-processors [18][19][20][21][22][23] working in conjunction with quantum computing systems [24][25][26][27][28][29

• how the proposed adjustment circuit will operate at finite (millikelvin) temperatures in the quantum regime and under the influence of relatively fast magnetic field control pulses? Will the tuning, coupling, and neromorphic co-processing circuits acquire new useful properties in the quantum regime

Dual-heterodyne Kelvin probe force microscopy

• Benjamin Grévin,
• Fatima Husainy,
• Dmitry Aldakov and
• Cyril Aumaître

Beilstein J. Nanotechnol. 2023, 14, 1068–1084, doi:10.3762/bjnano.14.88

• ). Working under modulated illumination also allows direct SPV measurements using special modulation/demodulation schemes, such as the one recently proposed by Miyazaki and co-workers for ac-bias KPFM [6]. In addition, most time-resolved KPFM modes developed so far rely on the use of a pulsed/modulated

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• a long list of ligands including modified serum albumin, which might also occur within our HBMPs [36]. The interaction of HbMPs (with different surface modifications) with Hp, as well as with anti-Hb antibodies has already been studied by Prapan and co-workers [19]. With this work, the investigation

• central iron ion is trivalent, and the Hb derivative has lost its ability to bind oxygen. Therefore, only bivalent Hb is functional. The “oxygen release method” was used to determine the percentage of functional hemoglobin, as previously described in detail by Kloypan and co-workers [33]. In brief, the

• block the monocytic membrane protein, as formerly described by Schaer and co-workers [27]. For a reference sample, the phagocytic capacity of monocytes was fully utilized for the uptake of FITC-labeled E. coli lysate over a period of 10 min at 37 °C (commercially available phagocytosis tests use lysate

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• of nanorods makes them excellent light absorbers for photothermal applications, while greater dimensions makes them efficient light scatterers for imaging applications [57]. The absorption and photothermal characteristics of four differently sized nanorods were analysed by Sun and co-workers. The

• , vol. 7, issue 6, © 2014, permission conveyed through Copyright Clearance Center, Inc. This content is not subject to CC BY 4.0.) Non-radiative mechanism in 2D semiconductor (C). (Figure 4B and C was reproduced from [38] (© 2020 Z. Xie et al., published by WILEY-VCH Verlag GmbH & Co. KGaA, distributed

Isolation of cubic Si₃P₄ in the form of nanocrystals

• Polina K. Nikiforova,
• Sergei S. Bubenov,
• Vadim B. Platonov,
• Andrey S. Kumskov,
• Nikolay N. Kononov,
• Tatyana A. Kuznetsova and
• Sergey G. Dorofeev

Beilstein J. Nanotechnol. 2023, 14, 971–979, doi:10.3762/bjnano.14.80

• 520.8 cm−1. Interestingly, the observed Raman spectrum for SP900 is very similar to that of the product of silicon and phosphorus MBE co-deposition at 3:2 molar ratio [34]. This substance was reported as amorphous; however, it could contain Si3P4 NPs along with other SixPy compounds. Factor group