Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• small interfering RNA) for hereditary transthyretin amyloidosis (ATTR) [10]. Here, we describe the mechanism of nanomedicine-based drug delivery for liver fibrosis treatment. In the following review, we briefly summarize the basic physiology of liver fibrosis, the interaction between NPs and the liver

• enhancing the antioxidant defense mechanism. Besides providing the containment for the active substance, the nanostructured lipid nanocarriers could be utilized for targeted delivery without conjugating any specific ligand. Composed of natural phospholipids, liposomes are generally considered to be

• work on designing nanocarriers for liver fibrosis and elucidating their work mechanism. Also, there are some difficulties to reevaluate the published toxicity reports and to compare them among each other because of non-standardized protocols used to evaluate the toxicity, leading to conflicting

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• solvent using the Doppler approach, which measures particle velocity as a function of voltage. The determination of the zeta potential is crucial in understanding the mechanism of drug–nanoparticle interactions [66]. In addition to the methods described above, Fourier-transform infrared spectroscopy is

Effect of wavelength and liquid on formation of Ag, Au, Ag/Au nanoparticles via picosecond laser ablation and SERS-based detection of DMMP

• Sree Satya Bharati Moram,
• Chandu Byram and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1054–1069, doi:10.3762/bjnano.15.86

• single alloy NP with a squared area was represented in Supporting Information File 1, Figure S5. It is evident from the figure that individual NPs encompassed both Ag and Au elements. The detailed mechanism underlying the formation of alloy NPs was elucidated in our previous study [44]. Earlier studies

Interface properties of nanostructured carbon-coated biological implants: an overview

• Mattia Bartoli,
• Francesca Cardano,
• Erik Piatti,
• Stefania Lettieri,
• Andrea Fin and
• Alberto Tagliaferro

Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85

• bacteria according to the mechanism shown in Figure 4. The biofilm formation consists of four stages, namely, (i) adhesion, (ii) aggregation, (iii) maturation, and (iv) dispersion. Adhesion is the first step and is ruled by the polarity of the surface as reported by Gittens and co-workers [105]. The

• hydrophobicity and nanostructuring [128][129]. Kang et al. [130] suggested that the main mechanism of action is cell disruption due to the mechanical effect of CNTs themselves via surface polarity changes. Rodrigues et al. [131] dwelled more deeply into CNT coatings and found a correlation between the exopolymer

Entry of nanoparticles into cells and tissues: status and challenges

• Kirsten Sandvig,
• Tore Geir Iversen and
• Tore Skotland

Beilstein J. Nanotechnol. 2024, 15, 1017–1029, doi:10.3762/bjnano.15.83

• to lysosomes. When it comes to entry of NPs into cells, normal tissue, and tumors there are still a number of open questions. Regarding questions on the cellular level: Can one modify the NPs to obtain more efficient targeting and entry? By which endocytic mechanism(s) are the NPs taken up? Will NPs

• with bound ligands enter by the same mechanism as the free ligands? Will the NPs affect intracellular transport and what are the consequences for the cell or tissue? In vivo, one might want NPs to be transcytosed across a cell layer. However, not much is known about the requirements for NPs to cross a

• involved in macropinocytosis, the CLIC/GEEC (clathrin-independent carrier/glycosylphosphatidylinositol (GPI)-anchored protein-enriched endosomal compartments) pathway, as well as in FEME (fast endophilin-mediated endocytosis) and phagocytosis (an uptake mechanism for large particles mostly found in

Atomistic insights into the morphological dynamics of gold and platinum nanoparticles: MD simulations in vacuum and aqueous media

• Evangelos Voyiatzis,
• Eugenia Valsami-Jones and
• Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 995–1009, doi:10.3762/bjnano.15.81

• scattering [23], and optical microscopy [24], have provided accurate estimates of nucleation rates and critical nucleation sizes, but little data have been produced for the sub-micrometer size regime regarding crystal facet formation and the mechanism of crystal growth. Moreover, a fundamental prerequisite

Recent progress on field-effect transistor-based biosensors: device perspective

• Billel Smaani,
• Fares Nafa,
• Mohamed Salah Benlatrech,
• Ismahan Mahdi,
• Hamza Akroum,
• Mohamed walid Azizi,
• Khaled Harrar and
• Sayan Kanungo

Beilstein J. Nanotechnol. 2024, 15, 977–994, doi:10.3762/bjnano.15.80

• . The first transduction mechanism is known as charge modulation, in which charged biomolecule species bind to the surface of the gate insulator and modify the charge density of the channel surface, and thus the surface conductivity by Coulomb interaction. This acts as a gating mechanism, and

• concurrently shifts the threshold voltage and modifies the drain current via channel conductivity modulation. The difference between the current (threshold voltage) in the presence of biomolecules and the current without biomolecules is used to define the current sensitivity. The second transduction mechanism

• material and silicon-on-insulator substrates with low-doped device layers and small nanowire diameters, achieving a fully depleted mechanism and allowing better surface-to-volume ratios and higher sensitivity applications. 2.2 Two-dimensional FET-based biosensors 2.2.1 Source-engineered Schottky barrier

Beyond biomimicry – next generation applications of bioinspired adhesives from microfluidics to composites

• Dan Sameoto

Beilstein J. Nanotechnol. 2024, 15, 965–976, doi:10.3762/bjnano.15.79

• lithography; Perspective As of the time of this writing, it has been 24 years since the seminal work by Kellar Autumn and his colleagues demonstrated how a single gecko foot hair could generate adhesion [1]. Autumn’s discovery that van der Waals forces were the primary mechanism behind the extraordinary

• easily adhered to in its soft state (Figure 2). Thus, it served as a dual-mechanism dry adhesive, although it could not operate with both mechanisms simultaneously. SMP materials are finding increasing use in newer versions of dry adhesives [30][31][32], and their full capabilities for switchable

• was initially applied as an adhesion mechanism for microfluidics, a distinct project I was working on in 2012, that required a reversible adhesion system offering high strength, low contamination, no damage to mating surfaces, and no need for separate glues, plasma treatments, or magnets. A simple

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• the mechanism of release of active material from the nanofibers can be adjusted by changing the type and composition of polymer or polymer blends used as matrix and the process parameters. Some of the parameters affecting the release are (i) degradation of the polymer matrix, (ii) molecular weight of

• regeneration of damaged bone tissue can take several weeks or even months, it is important to select a polymeric matrix capable of releasing drugs over an extended period of time to achieve optimum therapeutic efficiency. The polymer must also be chosen in accordance with the targeted release mechanism. It is

Effects of cutting tool geometry on material removal of a gradient nanograined CoCrNi medium entropy alloy

• Yu-Sheng Lu,
• Yu-Xuan Hung,
• Thi-Xuyen Bui and
• Te-Hua Fang

Beilstein J. Nanotechnol. 2024, 15, 925–940, doi:10.3762/bjnano.15.76

• : CoCrNi; gradient nanograined materials; Hall–Petch; molecular dynamics; relative tool sharpness; removal mechanism; Introduction Compared with traditional alloys, high-entropy alloys (HEAs) with multiple elements exhibit diverse and unprecedented mechanical properties, attracting widespread scientific

• CoCrNi MEA [9]. Lu et al. revealed the mechanism of the excellent strength, ductility, and work-hardening capacity of gradient nanograined (GNG) CrCoNi MEA samples [10]. However, it is complicated to fabricate experimentally GNG samples and to examine gradient grain structures. Therefore, this study

• chip thickness has the lowest average resultant force, consistent with the results of the surface morphology analysis in Figure 2. The subsurface quality of the workpiece significantly affects accuracy and durability in the machining process. To investigate the deformation mechanism of the subsurface

Water-assisted purification during electron beam-induced deposition of platinum and gold

• Cristiano Glessi,
• Fabian A. Polman and
• Cornelis W. Hagen

Beilstein J. Nanotechnol. 2024, 15, 884–896, doi:10.3762/bjnano.15.73

• different purification mechanism is possible since organic ligands could be removed from adsorbed precursor molecules by the electron-activated water species and cause a favourable decomposition of the adsorbed material (Figure 1, pathway B). Radiolysis of water can generate acid species, such as H3O+, that

A review on the structural characterization of nanomaterials for nano-QSAR models

• Salvador Moncho,
• Eva Serrano-Candelas,
• Jesús Vicente de Julián-Ortiz and
• Rafael Gozalbes

Beilstein J. Nanotechnol. 2024, 15, 854–866, doi:10.3762/bjnano.15.71

• involved in the activity modelled or that have a structural origin related to the activity mechanism. A very common property included in several models [23][44][60][68][76] is the zeta potential (a measurement of the charge at the surface of the NMs). The zeta potential value used as a descriptor can be

Investigation on drag reduction on rotating blade surfaces with microtextures

• Qinsong Zhu,
• Chen Zhang,
• Fuhang Yu and
• Yan Xu

Beilstein J. Nanotechnol. 2024, 15, 833–853, doi:10.3762/bjnano.15.70

• results. Second, the placement position and geometrical parameters (height, width, and spacing) of microtextures with lower energy loss were determined by our simulation of microtextures on the blade surface, and the drag reduction mechanism was analyzed. Triangular ribs with a height of 0.2 mm, a width

• velocimetry. Xiao et al. [9] analyzed the drag reduction mechanism of bionic microtextures and constructed simplified V-shaped, trapezoidal, and wavy ribs by grinding. Experimental and simulation studies on aeroengine blades with such microtextures showed that the drag reduction performance of wavy ribs is

• flow field on the smooth blade surface and provide references for the placement of microtextures. (2) The influence of microstructure size on drag reduction of blade surfaces was analyzed to determine the optimal parameters for microstructures. The drag reduction mechanism of the microstructures was

Intermixing of MoS₂ and WS₂ photocatalysts toward methylene blue photodegradation

• Maryam Al Qaydi,
• Nitul S. Rajput,
• Michael Lejeune,
• Abdellatif Bouchalkha,
• Mimoun El Marssi,
• Steevy Cordette,
• Chaouki Kasmi and
• Mustapha Jouiad

Beilstein J. Nanotechnol. 2024, 15, 817–829, doi:10.3762/bjnano.15.68

• pollutants is often driven by reactive agents, such as superoxide radicals, hydroxyl radicals, or photo-induced holes produced from either the conduction or valence bands [41][42]. The mechanism of the PD of MB under visible light excitation consists of several steps: Initially, the MB dye molecules are

• : The WS2/MoS2 composite exhibited significant enhancement of PD in terms of long-term stability, reaching up to 97% as shown in Figure 11 compared to that of WS2 and MoS2 taken alone. We assume this performance is ascribed to the mechanism of PD occurring in the composite sample. Precisely, when the

Exploring surface charge dynamics: implications for AFM height measurements in 2D materials

• Mario Navarro-Rodriguez,
• Andres M. Somoza and
• Elisa Palacios-Lidon

Beilstein J. Nanotechnol. 2024, 15, 767–780, doi:10.3762/bjnano.15.64

• monolayer flakes of 2D materials is the inaccurate height derived from topography images, often attributed to capillary or electrostatic forces. Here, we show the existence of a Joule dissipative mechanism related to charge dynamics and supplementing the dissipation due to capillary forces. This particular

• mechanism arises from the surface conductivity and assumes significance specially in the context of 2D materials on insulating supports. In such scenarios, the oscillating tip induces in-plane charge currents that in many circumstances constitute the main dissipative contribution to amplitude reduction and

• identify, in addition to the previously described interactions, an additional contribution to the tip–sample interaction due to the movement of charges on the surface induced by the oscillating tip. To understand and quantify this mechanism, we have proposed a very general model that solves Maxwell’s

Green synthesis of biomass-derived carbon quantum dots for photocatalytic degradation of methylene blue

• Dalia Chávez-García,
• Mario Guzman,
• Viridiana Sanchez and
• Rubén D. Cadena-Nava

Beilstein J. Nanotechnol. 2024, 15, 755–766, doi:10.3762/bjnano.15.63

• the samples from watermelon, showing similar behavior as the down-conversion process. Besides the main emission band centered around 720–730 nm, all samples exhibited a second band around 840 nm. Considering the upconversion PL mechanism, the authors consider that the presence of heteroatoms in the

• structure. Due to its size, the crystal structure effects can be enhanced. The expected mechanism for the photodegradation of MB is related with the formation of electron–hole pairs that, due to their oxidizing properties, promotes the formation of OH− radicals. These species are responsible for the

Effect of repeating hydrothermal growth processes and rapid thermal annealing on CuO thin film properties

• Monika Ozga,
• Eunika Zielony,
• Aleksandra Wierzbicka,
• Anna Wolska,
• Marcin Klepka,
• Marek Godlewski,
• Bogdan J. Kowalski and
• Bartłomiej S. Witkowski

Beilstein J. Nanotechnol. 2024, 15, 743–754, doi:10.3762/bjnano.15.62

• their work function. This modulation of work function holds immense significance, particularly in the context of electronic applications. Subsequent investigations will delve into comprehending the mechanism underlying the change in the work function value. Particularly, the impact of oxygen

Reduced subthreshold swing in a vertical tunnel FET using a low-work-function live metal strip and a low-k material at the drain

• Kalai Selvi Kanagarajan and
• Dhanalakshmi Krishnan Sadhasivan

Beilstein J. Nanotechnol. 2024, 15, 713–718, doi:10.3762/bjnano.15.59

• thermionic emission as the carrier injection mechanism [3]. Band-to-band tunneling enables TFETs to have SS < 60 mV/dec [4][5][6][7]. The gate-to-drain capacitance (Cgd) effect (Miller capacitance effect) has an impact on TFET performance. Unwanted effects such as overshoot/undershoot in the inverter

Elastic modulus of β-Ga₂O₃ nanowires measured by resonance and three-point bending techniques

• Annamarija Trausa,
• Sven Oras,
• Sergei Vlassov,
• Mikk Antsov,
• Tauno Tiirats,
• Andreas Kyritsakis,
• Boris Polyakov and
• Edgars Butanovs

Beilstein J. Nanotechnol. 2024, 15, 704–712, doi:10.3762/bjnano.15.58

• , trapezoid, and rectangular shapes (see Figure S1 in Supporting Information File 1). Only part of the NWs had Au catalyst particles at the end of the NW, which is an indication of VLS growth; therefore, suggesting that a large portion of NWs grew via the self-catalytic vapour–solid (VS) mechanism [24

• with Au nanoparticles (NPs, 100 nm of diameter, water suspension, Alfa Aesar) were positioned in a lower-temperature region 10 cm away from the furnace centre. Au NPs served as catalysts for the vapour–liquid–solid (VLS) growth mechanism. The reactor was heated to 1010 °C (high-temperature zone) under

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

• Nabojit Das,
• Vikas,
• Akash Kumar,
• Sanjeev Soni and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

• scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDX) of the powdered form of AuNM, as shown in Supporting Information File 1, Figure S4. Growth mechanism in AuNMs during seed-mediated synthesis Seed-mediated synthesis approach has been adopted in the present work which is quite

• well known to generate anisotropic nanomaterials. The mechanism mainly involves the arrangement of surfactant micelles which dictates anisotropy in nanoparticle during synthesis. A seed is a tiny crystal of ≈2–3 nm that initiates growth of a nanoparticle when introduced in a proper growth solution. The

• DTAB-AuNM, respectively. Growth mechanism of gold nanomakura particles (AuNM). (a) AuNM surrounded by surfactant micelles; (b) growth facet of AuNM; and (c) stepwise growth mechanism during AuNM formation. (a) Seed-mediated synthesis of CTAB-capped AuNR. (b) Seedless synthesis of DTAB-capped AuNR. (c

Laser synthesis of nanoparticles in organic solvents – products, reactions, and perspectives

• Theo Fromme,
• Sven Reichenberger,
• Katharine M. Tibbetts and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2024, 15, 638–663, doi:10.3762/bjnano.15.54

• with the [AuCl4]− reduction rate through a two-step autocatalytic nanoparticle growth mechanism [71]. The autocatalytic growth step is driven by H2O2 and can be slowed down by adding hydroxyl radical scavengers resulting in smaller nanoparticles (Figure 4) [48]. Hence, the water decomposition leads to

• proposed a mechanism of electron transfer from the solvent, which produced acetone as a by-product. Since this transfer is not possible in water and only plasma reactions are available, Ag could not nucleate during LRL in water because of the oxidizing activity of hydroxyl radicals [121]. Overall, LSPC in

• termination reaction with hydrogen, different end-capping groups such as CN or CH3 can be added [118][132][140][141][142][143]. While this mechanism for polyyne formation is widely accepted for ns-LAL, the synthesis of polyynes by fs-LAL is proposed to undergo different reactions. In contrast to ns-LAL, where

Comparative analysis of the ultrastructure and adhesive secretion pathways of different smooth attachment pads of the stick insect Medauroidea extradentata (Phasmatodea)

• Julian Thomas,
• Stanislav N. Gorb and
• Thies H. Büscher

Beilstein J. Nanotechnol. 2024, 15, 612–630, doi:10.3762/bjnano.15.52

• Julian Thomas Stanislav N. Gorb Thies H. Buscher Functional Morphology and Biomechanics, Institute of Zoology, Kiel University, Am Botanischen Garten 9, 24118 Kiel, Germany 10.3762/bjnano.15.52 Abstract The mechanism by which insects achieve attachment and locomotion across diverse substrates has

• roughness and thereby increase the contact area [14][16][17][18][19]. It can aid in the enhancement of viscous and capillary forces further increasing the attachment strength [9][14][20][21][22][23][24]. The adhesive secretion can be essential for the self-cleaning mechanism by binding smaller contamination

• structural mechanism for product release (e.g., a duct), and the presence of a dedicated storage area for their respective products (e.g., the adhesive secretion reservoir). Collectively, these distinctive features categorize the exocrine cells as exocrine cells type I [62]. Despite their morphological

Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy

• Yanyan Wen,
• Ningning Song,
• Yueyou Peng,
• Weiwei Wu,
• Qixiong Lin,
• Minjie Cui,
• Rongrong Li,
• Qiufeng Yu,
• Sixue Wu,
• Yongkang Liang,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49

• model has the highest degree of fitting with the release of NFs in different simulated environments within 72 h, which indicates conformity with the Fick diffusion mechanism. Meanwhile, we found that RF heating does not affect the release kinetics model. Ritger–Peppas is a semiempirical model, and n is

• an indicator of the drug release mechanism, where n ≤ 0.45 represents the Fick diffusion. The n values calculated in this study are all less than 0.45, indicating that the CUR release from NFs is in accordance with the Fick diffusion. Similarly, the Higuchi model has the highest degree of fitting

Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

• Horacio Emanuel Jerez,
• Yamila Roxana Simioni,
• Kajal Ghosal,
• Maria Jose Morilla and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

• due to the lower ALN internalization, resulting from the lower ALN/lipid ratio and lower endocytosis of the formulation. In either case, the mechanism of reduction of IL-6/IL-8 of ALN-loaded nanoarchaeosomes would differ from that mediated by the corticosteroid receptor since the corticosteroid

• dexamethasone did not affect HUVECs. The nanovesicles are internalized by endocytosis, a mechanism independent of their concentration and dose. Nanoarchaeosomes from H. tebenquichense are massively endocytosed, total or partly via SRA1, the receptor responsible for massive, high-rate internalization of

Photocatalytic degradation of methylene blue under visible light by cobalt ferrite nanoparticles/graphene quantum dots

• Vo Chau Ngoc Anh,
• Le Thi Thanh Nhi,
• Le Thi Kim Dung,
• Dang Thi Ngoc Hoa,
• Nguyen Truong Son,
• Nguyen Thi Thao Uyen,
• Nguyen Ngoc Uyen Thu,
• Le Van Thanh Son,
• Le Trung Hieu,
• Tran Ngoc Tuyen and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 475–489, doi:10.3762/bjnano.15.43

• /GQDs nanoparticles. Magnetic properties, morphology, structure, and fluorescence of the nanocomposites were studied, and the photocatalytic degradation of methylene blue as a dye model and the mechanism of methylene degradation were also addressed. Experimental Materials Cobalt(II) nitrate hexahydrate

• provides the value of k1. The values of k1, along with others from the literature, are presented in Table 3. However, because the reactions were conducted under different conditions, the comparison is arbitrary. To clarify the mechanism of MB photocatalytic degradation, 10 mM isopropyl (IPA), potassium

• photocorrosion and exhibits excellent reusability for the degradation process. The mechanism of MB degradation over the CF/GQDs catalyst is illustrated in Scheme 2. Under visible light irradiation, photogenerated holes (h+) are created in the valence bands via the transfer of photogenerated electrons (e−) from