Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• cells, BNZ is reduced by oxygen-sensitive nitroreductases. During its anaerobic nitro reduction, primarily in the hepatic microsomal fraction, BNZ generates reactive metabolites that bind to the host’s DNA, proteins, and lipids. The nitro reduction also occurs in fecal matter, with an intensity that

• idiosyncratic adverse drug reactions (ADRs), caused by BNZ reduction products, which are maximal in adults and lead to treatment discontinuation [19]. Typical ADRs include headache, anorexia, weakness and/or lack of energy, skin rash, gastrointestinal complaints, and mild, peripheral neurological effects [20

• nanomedicines capable of increasing the solubility of BNZ (Table 2). Trypomastigotes are known to display high resistance to the trypanocidal effect of BNZ [46][47]; replicative epimastigote and amastigote forms of the parasite, instead, would be sensitive to cumulative doses of BNZ. Arguing that a reduction in

Comparative electron microscopy particle sizing of TiO₂ pigments: sample preparation and measurement

• Ralf Theissmann,
• Christopher Drury,
• Markus Rohe,
• Thomas Koch,
• Jochen Winkler and
• Petr Pikal

Beilstein J. Nanotechnol. 2024, 15, 317–332, doi:10.3762/bjnano.15.29

• thresholding. While the former detection methods do not require any pre-processing of the image filtering of the obtained results, the automated detection methods require both noise reduction and contrast–brightness unification prior to the automated grey-value thresholding, and a shape- and grey value-based

• implemented definition. The new software package does not support the previously used watershed transform; instead, a morphological shape separator must be used. The better image quality allows one to reduce the size of the rank filter for noise reduction from five to two pixels. The differences are

Ultrasensitive and ultrastretchable metal crack strain sensor based on helical polydimethylsiloxane

• Shangbi Chen,
• Dewen Liu,
• Weiwei Chen,
• Huajiang Chen,
• Jiawei Li and
• Jinfang Wang

Beilstein J. Nanotechnol. 2024, 15, 270–278, doi:10.3762/bjnano.15.25

• reduction of current paths between the Au islands. This reduction in the number of effective Au bridges that can electrically connect the ruptured film portions under high strain results in a rapid increase in total resistance. Figure S3 (Supporting Information File 1) illustrates the measurement of

Design, fabrication, and characterization of kinetic-inductive force sensors for scanning probe applications

• August K. Roos,
• Ermes Scarano,
• Elisabet K. Arvidsson,
• Erik Holmgren and
• David B. Haviland

Beilstein J. Nanotechnol. 2024, 15, 242–255, doi:10.3762/bjnano.15.23

• the measured magnitude and phase response of two nominally identical devices, both with nanowire width w = 200 nm, where one device has the shunt inductance and the other does not. For a shunt with inductance Ls = 195 pH, we increase Qext by a factor of roughly twenty at the cost of a slight reduction

Exploring disorder correlations in superconducting systems: spectroscopic insights and matrix element effects

• Vyacheslav D. Neverov,
• Alexander E. Lukyanov,
• Andrey V. Krasavin,
• Alexei Vagov,
• Boris G. Lvov and
• Mihail D. Croitoru

Beilstein J. Nanotechnol. 2024, 15, 199–206, doi:10.3762/bjnano.15.19

• and the two coherence peaks at its edges depend on α. Notably, the gap exhibits a discernible reduction with increasing α. In the case of uncorrelated disorder with α = 0, the gap is approximately 80% larger compared to the scenario with α = 2. Simultaneously, the coherence peaks gradually vanish with

• parameter α increases, effectively diminishing the disorder strength. On the other hand, the enhanced level of disorder correlations leads to a reduction in the spectroscopic gap, highlighting that an increase in the level of disorder correlations does not equate to a decrease in disorder. Conclusion Our

• investigation on the impact of disorder correlations on superconductivity has yielded valuable insights into the behavior of the quasiparticle density of states within superconducting samples. The averaged quasiparticle density of states has revealed several important findings. First, we observed a reduction in

CdSe/ZnS quantum dots as a booster in the active layer of distributed ternary organic photovoltaics

• Gabriela Lewińska,
• Piotr Jeleń,
• Zofia Kucia,
• Maciej Sitarz,
• Łukasz Walczak,
• Bartłomiej Szafraniak,
• Jerzy Sanetra and
• Konstanty W. Marszalek

Beilstein J. Nanotechnol. 2024, 15, 144–156, doi:10.3762/bjnano.15.14

• profile. The addition of quantum dots to the layer increases its roughness parameters. The surface also shows greater morphological differentiation in the form of numerous peaks present throughout the surface. The third component in the BHJ for the systems studied so far supported a reduction in roughness

Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions

• Pathirannahalage Sahan Samuditha,
• Nadeesh Madusanka Adassooriya and
• Nazeera Salim

Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11

• (Chl-b), total chlorophylls, carotenoids, and antioxidants by 24.7%, 58.5%, 38.0%, 42.2%, 39.9%, 11.2%, and 7.7%, respectively. Interestingly, this dose had no impact on the indole acetic acid (IAA) content. Conversely, the use of 2,000 mg/L of ZnO NPs in the same medium led to a significant reduction

• Fusarium wilt in Solanum melongena L. while enhancing its carbohydrates and chlorophyll contents [13]. In contrast, a significant reduction of chlorophyll fluorescence of Hordeum sativum (barley) treated with 2000 mg/L of ZnO NPs compared to 300 mg/L of ZnO NPs has also been reported [41]. These pieces of

New application of bimetallic Ag/Pt nanoplates in a colorimetric biosensor for specific detection of E. coli in water

• Azam Bagheri Pebdeni,
• Mohammad N. AL-Baiati and
• Morteza Hosseini

Beilstein J. Nanotechnol. 2024, 15, 95–103, doi:10.3762/bjnano.15.9

• aptamers, which changed to −6 mV. A reduction in the zeta potential of the aptamer-Ag/Pt NPLs revealed that the aptamer was effectively changed on the surface of NPLs. In comparison to E. coli and aptamer-NPLs, the negative charge of aptamer-NPL-E. coli reduced to −10 mV after incubation time, indicating

• /Pt NPLs A modified chemical reduction method was used to create Ag NPLs [26][38]. The aqueous solution synthesis of Ag-Pt NPL is described below. To begin, 50 L of 0.05 M AgNO3 aqueous solution was mixed with 10 mL of 2.5 × 10−4 M sodium citrate aqueous solution. After that, 25 µL of 0.1 M ascorbic

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• the surface of the fibers. In addition, the reduction in the hydrophobicity of the nanofiber network also caused a faster release of the drug. Meanwhile, the hydrophobic PLA nanofiber carrier showed a sustained release behavior of the Dox-base. This was because hydrophobic Dox-base significantly

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• ]. Pentamidine-loaded nanoparticles also showed great results due to the nanostructure. Free pentamidine and Pentamidine-NPs were administered orally in an in vivo experimental model of mice infected with visceral leishmaniasis. Only the nanoencapsulated drug showed a significant reduction in the relative weight

Measurements of dichroic bow-tie antenna arrays with integrated cold-electron bolometers using YBCO oscillators

• Leonid S. Revin,
• Dmitry A. Pimanov,
• Alexander V. Chiginev,
• Anton V. Blagodatkin,
• Viktor O. Zbrozhek,
• Andrey V. Samartsev,
• Anastasia N. Orlova,
• Dmitry V. Masterov,
• Alexey E. Parafin,
• Victoria Yu. Safonova,
• Anna V. Gordeeva,
• Andrey L. Pankratov,
• Leonid S. Kuzmin,
• Anatolie S. Sidorenko,
• Silvia Masi and
• Paolo de Bernardis

Beilstein J. Nanotechnol. 2024, 15, 26–36, doi:10.3762/bjnano.15.3

• efficient reduction of electron temperature down to 65 mK from a base temperature of 300 mK [22]. Here we present improved simulation results in comparison with [24] and the first results of fabrication and measurements, using YBa2Cu3O7 (YBCO) Josephson junction (JJ) oscillators, of a dichroic multiabsorber

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• scavenge free radicals [27]. After that, many authors related a reduction in oxidative stress markers in vivo after metalic nanoparticle administration and/or amelioration in histopathological characteristics after infection, which corroborates the first hypothesis [27][28][29][30][31][32][33][34]. Solid

• juvenile forms. It was also noted alterations in parasite tegument and a reduction in granulomatous reactions in murine liver. Although finding new forms to improve PZQ characteristics is essential, it would not solve the problem once only this drug is available to treat the disease and resistant strains

• nanoparticles, the author considered the results not good enough since other works showed a more prominent reduction [62]. Regarding egg counts in the liver and intestine, the nanoformulation was more efficient than blank particles which shows the relevance of nanoparticle for drug delivery. The

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells

• Eloïse Equy,
• Jordana Hirtzel,
• Sophie Hellé,
• Béatrice Heurtault,
• Eric Mathieu,
• Morgane Rabineau,
• Vincent Ball and
• Lydie Ploux

Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100

• the BSA/PDA-NPs upon oxidation (suggested by the insignificant decrease in size of Ox-BSA/PDA NPs compared to pristine BSA/PDA NPs) and a reduction of concentration or molar extinction coefficient during the prolonged oxidation. Indeed, it is well known that the oxidation of indole quinone groups in

A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH₃)₂Cl]₂

• Elif Bilgilisoy,
• Ali Kamali,
• Thomas Xaver Gentner,
• Gerd Ballmann,
• Sjoerd Harder,
• Hans-Peter Steinrück,
• Hubertus Marbach and
• Oddur Ingólfsson

Beilstein J. Nanotechnol. 2023, 14, 1178–1199, doi:10.3762/bjnano.14.98

• 10.1 nm, respectively). At 3 nA, on the other hand, a clear size reduction to 8.2 nm is observed in the SEM images. This size reduction with increasing deposition current is even clearer from the AFM images as discussed in the following section. From the AES data shown in Figure 3c, the atomic

• correlated with the decrease in carbon content, which is also reflected in the proportionally increasing Sn contaminations showing the same trend as that of gold. This is more evident from the reduction of the carbon peak areas in the AES, which is ≈36% when comparing the depositions at 0.4 and 3 nA, and ≈14

• % when comparing the depositions at 0.4 and 1.5 nA. We thus attribute the observed size reduction of the deposited gold particles with increasing deposition current to the decrease in carbon content. A similar size reduction of gold nanoparticles has been reported for post-deposition oxidative

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• measured. The results show that the plasma insulin levels where higher for harder NPs, and this correlated with blood glucose reduction. Furthermore, 3 h after application, they found a larger amount of hard NPs in the intestinal villi [40]. All studies support our hypothesis that mechanical properties of

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• stability and solubility [9]. The complexation occurs mainly through hydrophobic interactions in protein cavities [10][11]. In a recent study, zein nanoparticles loaded with CUR have been studied for their potential in treating brain tumors, and the results have demonstrated a reduction in the proliferation

• . Moreover, after 48 h, both free CUR and CUR-HSA-MPs exhibit stronger toxic effects against Huh-7 than against MCF-7 cells. In line with earlier studies on CUR-loaded gold/chitosan nanogels, a higher concentration-dependent cell viability reduction is induced in Huh-7 cells than in MCF-7 cancerous cells [44

Sulfur nanocomposites with insecticidal effect for the control of Bactericera cockerelli

• Lany S. Araujo-Yépez,
• Juan O. Tigrero-Salas,
• Vicente A. Delgado-Rodríguez,
• Vladimir A. Aguirre-Yela and
• Josué N. Villota-Méndez

Beilstein J. Nanotechnol. 2023, 14, 1106–1115, doi:10.3762/bjnano.14.91

• , and O, corresponding to the by-products of the reduction of sodium thiosulfate to sulfur (see Experimental section), were found [19][31][34]. Carbon is from the substrate used in the EDS analysis [35][36]. The TEM micrograph in Figure 3a reveals the formation of spherical SNPs that agglomerate into

Experimental investigation of usage of POE lubricants with Al₂O₃, graphene or CNT nanoparticles in a refrigeration compressor

• Kayhan Dağıdır and
• Kemal Bilen

Beilstein J. Nanotechnol. 2023, 14, 1041–1058, doi:10.3762/bjnano.14.86

• requires a power input to perform this compression process. The same applies to refrigeration compressors. Therefore, a reduction in compressor power consumption means an increase in compressor performance. In this study, three types of nanoparticles, called Al2O3, graphene, and CNTs, were experimentally

• Figure 13c, it was observed that the compressor electrical power required to provide similar operating conditions decreased as the CNTs mass fraction reached up to 0.250%, and then increased again. The maximum reduction in compressor electrical power obtained with the addition of CNT nanoparticles

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• sample and the corresponding reduction in the other samples provided information about the extent of phagocytosis in the pre-feeding step. For each experimental run, blood from a different donor was used. Due to the donors’ variability (e.g., different cell counts, immune cell activity, or surface

• ). Keeping the cells at a temperature of 0 °C as negative controls, effectively prevented phagocytic activity (average MFI: 42.3 ± 7.4; reduction in respect to reference: 90.6% ± 1.6%). If the cells were allowed to phagocytose unlabeled E. coli lysate for a period of 2 h beforehand and only thereafter were

• protein CD163 with a specific anti-CD163 antibody had no inhibitory effect on phagocytosis of FITC-labeled (AB-block) and unlabeled E. coli lysate (AB-block-EC-prefed-120′). Pre-feeding the cells with our HbMPs for 120 min (HbMP-prefed-120′) resulted in a reduction of MFI (47.1% ± 8.8%), slightly lower

Exploring internal structures and properties of terpolymer fibers via real-space characterizations

• Michael R. Roenbeck and
• Kenneth E. Strawhecker

Beilstein J. Nanotechnol. 2023, 14, 1004–1017, doi:10.3762/bjnano.14.83

• expect that these features resulted from the way this particular fiber split open after FIB notching. Likewise, the lone drop in stiffness makes sense, as the AFM probe experiences a local reduction in tip–substrate contact area. However, similar topography and stiffness jumps forming a compliant band

• another. This compliance likely stems from a local reduction in contact area, as sudden changes in height up to tens of nanometers can occur at these interfaces (Figure 7a). Nevertheless, these are “real” ET values; in other words, these local gaps in the fiber would affect ET of the full fiber

Low temperature atomic layer deposition of cobalt using dicobalt hexacarbonyl-1-heptyne as precursor

• Mathias Franz,
• Mahnaz Safian Jouzdani,
• Lysann Kaßner,
• Marcus Daniel,
• Frank Stahr and
• Stefan E. Schulz

Beilstein J. Nanotechnol. 2023, 14, 951–963, doi:10.3762/bjnano.14.78

• defined by the onset of the decomposition of the precursor. In our case, decomposition occurs at temperatures of 125 °C and above, resulting in a film growth in chemical vapour deposition mode. The lower limit of the ALD window is around 35 °C, where the reduction of the precursor is incomplete. The

Prediction of cytotoxicity of heavy metals adsorbed on nano-TiO₂ with periodic table descriptors using machine learning approaches

• Joyita Roy,
• Souvik Pore and
• Kunal Roy

Beilstein J. Nanotechnol. 2023, 14, 939–950, doi:10.3762/bjnano.14.77

• datasets with great efficiency [27]. It can be regarded as a dimensionality reduction method since it analyzes large input data and finds all important variables. While handling RF datasets, the model emphasizes the importance of parameters, which is a highly helpful aspect [28]. Adaptive boosting

Upscaling the urea method synthesis of CoAl layered double hydroxides

• Camilo Jaramillo-Hernández,
• Víctor Oestreicher,
• Martín Mizrahi and
• Gonzalo Abellán

Beilstein J. Nanotechnol. 2023, 14, 927–938, doi:10.3762/bjnano.14.76

• spectroscopic techniques (ATR-FTIR, UV–vis, XPS, ICP-MS, and XANES-EXAFS). In the case of the volumetric scale-up, a reduction of 45% in the lateral dimensions of the crystals (from 3.7 to 2.0 µm) is observed as the reaction volume increases. This fact is related to modified heating processes affecting the

• crystals of around 3.7 ± 1.0 µm are observed, in good agreement with [13]. Interestingly, pure CoAl-based LDH scale-up samples exhibit a reduction of around 45% in size and a lack of sharp edges, regardless of the synthesis approach. In the case of mass scale-up protocols, these differences can arise from

• concentration increase (x25M), the formation of a simonkolleite-like Co-based layered hydroxide impurity is observed, indicating phase competition during precipitation related to the thermodynamic stability of the growing phases. In the case of the volumetric scale-up, a reduction of ca. 45% of the particle

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• the reduction of disulfide bonds. Thiols, also called sulfhydryls, in the cysteine side chain are slightly less abundant than primary amines; therefore, the coupling by thiol groups is more selective [52]. Thiols in cysteines are linked by disulfide bonds (–S–S–) through an oxidation process where the

• proteins that do not have free thiol groups, such groups can be generated either by reducing the disulfide bonds (DTT and BME) or by introducing cysteine residues (Traut’s reagent and N-succinimidyl S-acetylthioacetate) at different positions. The reaction with primary amines or the reduction of disulfide

• properties by reducing surface charge and availability of conjugated molecules on the NPs, which results in a reduction of targeting capacity from 70% to 7%. However, HAS-incubated NPs exhibited increased interaction between targeting molecule and ligand, boosting the targeting capacity of Afb-conjugated NPs

Ni, Co, Zn, and Cu metal-organic framework-based nanomaterials for electrochemical reduction of CO₂: A review

• Ha Huu Do and
• Hai Bang Truong

Beilstein J. Nanotechnol. 2023, 14, 904–911, doi:10.3762/bjnano.14.74

• of converting CO2 into valuable chemicals through electrochemical techniques has garnered significant attention. Metal-organic frameworks (MOFs) have occured as highly prospective materials for the reduction of CO2, owing to their exceptional attributes including extensive surface area, customizable

• architectures, pronounced porosity, abundant active sites, and well-distributed metallic nodes. This article commences by elucidating the mechanistic aspects of CO2 reduction, followed by a comprehensive exploration of diverse materials encompassing MOFs based on nickel, cobalt, zinc, and copper for efficient

• CO2 conversion. Finally, a meticulous discourse encompasses the challenges encountered and the prospects envisioned for the advancement of MOF-based nanomaterials in the realm of electrochemical reduction of CO2. Keywords: carbon capture; CO2 reduction; electrocatalysis; metal-organic frameworks