Beyond biomimicry – next generation applications of bioinspired adhesives from microfluidics to composites

• Dan Sameoto

Beilstein J. Nanotechnol. 2024, 15, 965–976, doi:10.3762/bjnano.15.79

• terms of new applications for biomimetic adhesives for truly substantial industrial impacts to be made. These new application areas are my primary research focus today; it makes the efforts of all those who have participated in the academic and industrial development of the field more valuable. How can

• have been applied to previously, and a very promising application is the development of shape- and stiffness-tunable composites. Anyone familiar with the movies “The Terminator” or “Big Hero 6” has seen a sci-fi version of robots that can change their shape, size, or function. Science fiction offers

• adaptability, sustainability, and product performance. The future of reversible adhesives will come from looking within, and going beyond, biomimicry. Chronological development of different gecko adhesive manufacturing processes that were developed by the author and then adapted by future students. Process (A

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• Minh City, 700000, Vietnam Institute of Chemical Technology – VAST, Ho Chi Minh City, 700000, Vietnam Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam 10.3762/bjnano.15.78 Abstract Theragnostic platforms, which integrate

• therapeutic and diagnostic capabilities, have gained significant interest in drug research because of to their potential advantages. This study reports the development of a novel multifunctional nanoparticle carrier system based on poly(ᴅ,ʟ-lactic-co-glycolic acid) (PLGA) for the targeted delivery of the

• folate on the surface of nanoparticles promotes the internalization of nanoparticles by cancer cells. Within the cell, the CHL released from the nanoparticles would bind to DNA and halt the development of cancer cells. Without CHL, the nanoparticles had no cytotoxic impact on the cells (data not shown

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• and lamellar bone. Woven bone is a transitional bone type observed in embryonic skeletons or growing bones, as well as during pathological conditions such as fracture repair or tumor. It gradually transforms into lamellar bone during the remodeling process in normal development or healing. In this

• both trigger the bone healing process and provide mechanical support to damaged bone. Currently, research on bone healing has focused on the development of biomaterials that can be used as economic, biocompatible, and controllable bone substitutes. Studies have centered on biomaterials that can imitate

• hard bone-like tissues. Calcified bone tissue shows different mechanical properties depending on the collagen sequence in the natural structure. The polymers used in the development of polymeric nanofibers should have mechanical and biological properties suitable for calcified hard tissue structures

Identification of structural features of surface modifiers in engineered nanostructured metal oxides regarding cell uptake through ML-based classification

• Indrasis Dasgupta,
• Totan Das,
• Biplab Das and
• Shovanlal Gayen

Beilstein J. Nanotechnol. 2024, 15, 909–924, doi:10.3762/bjnano.15.75

• using the fivefold cross-validation procedure. Additionally, the model’s quality was evaluated by looking at the receiver operating characteristic (ROC) plot as well as specificity, sensitivity, and accuracy values [40][41][42]. Development of other machine learning models Calculation of descriptors and

• data pre-treatment The training set of 88 and the test set of 21 surface modifiers from Bayesian classification analysis were used for the development of other machine learning models. Different classes of 2D descriptors were calculated using PaDEL-Descriptor [43]. The data pre-treatment tool (Data Pre

• had an absolute difference greater than or equal to 0.39 and 0.19, respectively. The specific values were determined through empirical analysis, ensuring that the selected descriptors provide the best predictive performance for each cell line. ML model development and analysis Four classification

A review on the structural characterization of nanomaterials for nano-QSAR models

• Salvador Moncho,
• Eva Serrano-Candelas,
• Jesús Vicente de Julián-Ortiz and
• Rafael Gozalbes

Beilstein J. Nanotechnol. 2024, 15, 854–866, doi:10.3762/bjnano.15.71

• approaches. Furthermore, when they are developed complying strictly with the rules established by the Organization for Economic Co-operation and Development (OECD) for their scientific validation, QSARs are accepted for regulatory purposes, thus ensuring their applicability at the regulatory level by

• active field and, recently, a comprehensive review about this topic and the future perspectives was published [7]. Scientific, industrial, and national institutions should harmonize their efforts for the development and application of nano-QSARs at the regulatory level [9]. From a regulatory point of

• preparation and handling) will lead to different structural configurations and to different properties. Thus, the reported experimental conditions are significant, and they often need to be included in a predictive model. Finally, the quality of data is a key component in the development of QSAR models

When nanomedicines meet tropical diseases

• Eder Lilia Romero,
• Katrien Van Bocxlaer and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 830–832, doi:10.3762/bjnano.15.69

• Eder Lilia Romero Katrien Van Bocxlaer Fabio Rocha Formiga Nanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, B1876 Bernal, Provincia de Buenos Aires, Argentina Skin Research Centre, Hull York Medical School

• those diseases. However, apart from the symbolism behind the World Neglected Tropical Diseases Day, research initiatives fighting NTDs have been conducted over the last years, paving the way for the development of new programs for prevention, diagnosis, and treatment of NTDs. A number of institutions

• important contribution to this thematic issue focused on development of nanoemulsions containing plant-based insecticides for vector control. In this work, Duarte and colleagues developed and characterized nanoemulsions encapsulating monoterpenes, which exhibited significant lethality against third-instar

Intermixing of MoS₂ and WS₂ photocatalysts toward methylene blue photodegradation

• Maryam Al Qaydi,
• Nitul S. Rajput,
• Michael Lejeune,
• Abdellatif Bouchalkha,
• Mimoun El Marssi,
• Steevy Cordette,
• Chaouki Kasmi and
• Mustapha Jouiad

Beilstein J. Nanotechnol. 2024, 15, 817–829, doi:10.3762/bjnano.15.68

• several cycles. This finding underscores the advantageous outcomes of intermixing WS2 and MoS2, shedding light on the development of an efficient and enduring photocatalyst for visible-light-driven photodegradation of methylene blue. Keywords: methylene blue; MoS2/WS2 composite; photocatalysis

• place corrective actions for the development of efficient strategies for water treatment [3]. Following these measures, various technologies have proven their efficacy for water depollution, including adsorption and photocatalysis, and are often utilized for heavy metals, pharmaceuticals, pesticide

• evaluation under real conditions under sunlight showed an increased PD efficiency. Overall, our approach is cost-effective, reproducible, and can be further employed in the development of composites processed by CVD, providing a potential solution to address the growing concerns of environmental pollution

Green synthesis of biomass-derived carbon quantum dots for photocatalytic degradation of methylene blue

• Dalia Chávez-García,
• Mario Guzman,
• Viridiana Sanchez and
• Rubén D. Cadena-Nava

Beilstein J. Nanotechnol. 2024, 15, 755–766, doi:10.3762/bjnano.15.63

• the efficacy of the top-down hydrothermal method for CQD production, offering insights for tailored applications and emphasizing the potential of biomass-derived nanomaterials in environmental remediation and biomedicine, paving the way for the development of sustainable and effective technologies. UV

Effect of repeating hydrothermal growth processes and rapid thermal annealing on CuO thin film properties

• Monika Ozga,
• Eunika Zielony,
• Aleksandra Wierzbicka,
• Anna Wolska,
• Marcin Klepka,
• Marek Godlewski,
• Bogdan J. Kowalski and
• Bartłomiej S. Witkowski

Beilstein J. Nanotechnol. 2024, 15, 743–754, doi:10.3762/bjnano.15.62

• methods becomes important for their continued enhancement and optimization. Such endeavors might consequently lead to the development of novel techniques for producing films tailored to specific parameters and purposes. The preparation of CuO thin films using various techniques is reported in the

• films, attributed to the presence of organic residues within the samples, necessitated the development of innovative solutions. These solutions aimed to lower the organic compound content while concurrently enabling modifications to the resultant material’s properties. As elucidated in this study, the

Elastic modulus of β-Ga₂O₃ nanowires measured by resonance and three-point bending techniques

• Annamarija Trausa,
• Sven Oras,
• Sergei Vlassov,
• Mikk Antsov,
• Tauno Tiirats,
• Andreas Kyritsakis,
• Boris Polyakov and
• Edgars Butanovs

Beilstein J. Nanotechnol. 2024, 15, 704–712, doi:10.3762/bjnano.15.58

• suitable for use on bendable and stretchable substrates in line with the current trends in electronic technologies focusing on flexible electronic device development [11][12]. Consequently, understanding the mechanical properties of β-Ga2O3 NWs becomes an important step. For instance, precise determination

Enhancing higher-order modal response in multifrequency atomic force microscopy with a coupled cantilever system

• Wendong Sun,
• Jianqiang Qian,
• Yingzi Li,
• Yanan Chen,
• Zhipeng Dou,
• Rui Lin,
• Peng Cheng,
• Xiaodong Gao,
• Quan Yuan and
• Yifan Hu

Beilstein J. Nanotechnol. 2024, 15, 694–703, doi:10.3762/bjnano.15.57

• the higher-order modal response of the coupled system gradually increases, which will improve the sensitivity of the detection and promote the development of multifrequency AFM utilizing higher-order modes of the cantilever to image sample properties. Finite element analysis Model size and simulation

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

• Nabojit Das,
• Vikas,
• Akash Kumar,
• Sanjeev Soni and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

• aspiring venture of soft intelligent materials [19]. Soft intelligent materials are primarily hydrogel materials that are stimuli responsive. A recent study showed the use of hydrogels by incorporating gold nanorods for the development of thermo-responsive actuators [20]. The photothermal conversion of

Functional fibrillar interfaces: Biological hair as inspiration across scales

• Guillermo J. Amador,
• Brett Klaassen van Oorschot,
• Caiying Liao,
• Jianing Wu and
• Da Wei

Beilstein J. Nanotechnol. 2024, 15, 664–677, doi:10.3762/bjnano.15.55

• microscopic pillars. The superhydrophobic surface is self-cleaning since water droplets bead up on the surface, and, when they roll off, they pick up any dirt or other particles and remove them from the leaf’s surface. This phenomenon was termed the “Lotus effect” and has been translated to the development of

• classifications. Future research linking form and function in microbial hairs may lead to a better understanding of their evolution, as well as providing inspiration for the development of functional fibrillar structures at the micrometer and nanometer scales. Filter feeding Locomotion is key for searching for

Exfoliation of titanium nitride using a non-thermal plasma process

• Priscila Jussiane Zambiazi,
• Dolores Ribeiro Ricci Lazar,
• Larissa Otubo,
• Rodrigo Fernando Brambilla de Souza,
• Almir Oliveira Neto and
• Cecilia Chaves Guedes-Silva

Beilstein J. Nanotechnol. 2024, 15, 631–637, doi:10.3762/bjnano.15.53

• composition of TiN were preserved, the crystallite size was reduced. These TiN nanosheets have a great potential for a range of cutting-edge applications in fields such as medicine, catalysis, and energy-related technologies. Hence, further exploration and development of these TiN nanosheets are expected to

Comparative analysis of the ultrastructure and adhesive secretion pathways of different smooth attachment pads of the stick insect Medauroidea extradentata (Phasmatodea)

• Julian Thomas,
• Stanislav N. Gorb and
• Thies H. Büscher

Beilstein J. Nanotechnol. 2024, 15, 612–630, doi:10.3762/bjnano.15.52

• the material composition of attachment pads and the distribution process of the adhesive secretion can potentially aid in the development of more effective artificial attachment systems. Keywords: adhesion; arolium; biomechanics; euplantulae; friction; functional morphology; tarsal secretion

AFM-IR investigation of thin PECVD SiO_x films on a polypropylene substrate in the surface-sensitive mode

• Hendrik Müller,
• Hartmut Stadler,
• Teresa de los Arcos,
• Adrian Keller and
• Guido Grundmeier

Beilstein J. Nanotechnol. 2024, 15, 603–611, doi:10.3762/bjnano.15.51

• of spatial resolution. In ATR-IR spectroscopy, the resolution is theoretically limited by λ/2, which corresponds to several µm [3]. In contrast, the development of new and powerful tunable IR laser sources, such as optical parametric oscillator (OPO) and quantum cascade lasers (QCL), enabled a

• refined and found its way into many and highly diverse fields of application, including virology, DNA nanotechnology, polymer science, and materials science [5][6][7][8][9]. The importance of AFM-IR steadily grew over the past decade and its development has been described in detail in several review

Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy

• Yanyan Wen,
• Ningning Song,
• Yueyou Peng,
• Weiwei Wu,
• Qixiong Lin,
• Minjie Cui,
• Rongrong Li,
• Qiufeng Yu,
• Sixue Wu,
• Yongkang Liang,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49

• significant side effects such as hypertension, proteinuria, and skin toxicity [7][8]. Hence, there is a pressing need to develop new therapeutic modalities that offer substantial efficacy while minimizing side effects. Extensive efforts have been dedicated to drug development and delivery technologies in

• , China). Ultrapure water was obtained from a Laibopate purification system (Changchun Lab Partner Technology Development Co., Ltd., Changchun, China) and used in all experiments. Human hepatocellular carcinoma cells (Huh-7 cells) and Dulbecco’s modified Eagle’s medium (DMEM, ZQ-101) were purchased from

• Shanghai Zhongqiao Xinzhou Biotechnology Co., Ltd. (Shanghai, China). Preparation of Fe3O4 NCs Fe3O4 NCs were synthesized using a microwave hydrothermal synthesis method with a computer microwave ultrasonic synthesis/extraction instrument (XH-300A+, Beijing Xianghu Technology Development Co., Ltd., Beijing

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

• Shan He,
• Julen Segura Abarrategi,
• Harbil Bediaga,
• Sonia Arrasate and
• Humberto González-Díaz

Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47

• diseases are characterized by slowly progressing neuronal cell death. Conventional drug treatment strategies often fail because of poor solubility, low bioavailability, and the inability of the drugs to effectively cross the blood–brain barrier. Therefore, the development of new neurodegenerative disease

• , we consider AI/ML to be helpful in the development of N2D3Ss to select the most efficient combination of NP and drug, taking into account properties regarding chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET), and the biological activity regarding NDs [20]. Nevertheless

• data to be explored. As a result, N2D3S development by the additive approach requires an AI/ML technique to achieve multioutput and multilabel classification [21][22][23][24]. In addition, the AI/ML technique includes a pre-processing step to perform information fusion (IF) of the preclinical NDD assay

Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

• Horacio Emanuel Jerez,
• Yamila Roxana Simioni,
• Kajal Ghosal,
• Maria Jose Morilla and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

• Horacio Emanuel Jerez Yamila Roxana Simioni Kajal Ghosal Maria Jose Morilla Eder Lilia Romero Nanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Sáenz Peña 352, Bernal, Buenos Aires, Argentina Department of Pharmaceutical

• variable degrees of increased permeability, offering an anatomic-pathological context that favors extravasation and, therefore, the passive targeting of nanoparticulate material towards cells of the diseased vasculature [20]. Moreover, in recent years, the development of targeted nanomedicines for

• increasingly pursued “quality by design” criteria [24]. The development of structurally simple formulations that facilitate their scaling and further characterization is, therefore, a critical task [25]. Also, targeting nanomedicines to circulating cells and vascular walls is difficult since it should occur

Electron-induced deposition using Fe(CO)₄MA and Fe(CO)₅ – effect of MA ligand and process conditions

• Hannah Boeckers,
• Atul Chaudhary,
• Petra Martinović,
• Amy V. Walker,
• Lisa McElwee-White and
• Petra Swiderek

Beilstein J. Nanotechnol. 2024, 15, 500–516, doi:10.3762/bjnano.15.45

• interesting magnetic properties [9][14][15]. However, considering that Fe is by orders of magnitude more abundant than Co, the further development of FEBID processes based on Fe precursors is appealing. Although there were early attempts to use triiron dodecacarbonyl (Fe3(CO)12) or ferrocene (Fe(C5H5)2) for

Aero-ZnS prepared by physical vapor transport on three-dimensional networks of sacrificial ZnO microtetrapods

• Veaceslav Ursaki,
• Tudor Braniste,
• Victor Zalamai,
• Emil Rusu,
• Vladimir Ciobanu,
• Vadim Morari,
• Daniel Podgornii,
• Pier Carlo Ricci,
• Rainer Adelung and
• Ion Tiginyanu

Beilstein J. Nanotechnol. 2024, 15, 490–499, doi:10.3762/bjnano.15.44

• under (a) resonant and (b) intraband excitation. Funding This research was funded by the National Agency for Research and Development of Moldova under the grants no. 22.80013.5007.4BL and no. 20.80009.5007.15, and by the Ministry of Education and Research from Republic of Moldova within the program no

Photocatalytic degradation of methylene blue under visible light by cobalt ferrite nanoparticles/graphene quantum dots

• Vo Chau Ngoc Anh,
• Le Thi Thanh Nhi,
• Le Thi Kim Dung,
• Dang Thi Ngoc Hoa,
• Nguyen Truong Son,
• Nguyen Thi Thao Uyen,
• Nguyen Ngoc Uyen Thu,
• Le Van Thanh Son,
• Le Trung Hieu,
• Tran Ngoc Tuyen and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 475–489, doi:10.3762/bjnano.15.43

• , Vietnam Center for Advanced Chemistry, Institute of Research & Development, Duy Tan University, Vietnam Faculty of Natural Sciences, Duy Tan University, Vietnam University of Education and Science, The University of Danang, Vietnam 10.3762/bjnano.15.43 Abstract A simple approach was developed to

• acid in a controlled manner, and CF; the material was used to reduce 4-nitrophenol with a very high rate constant compared to the individual components [11]. Despite various advancements in preparation techniques for nanocatalysts, the development of a well-controlled method remains a challenge. In

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• Hsuan-Ang Tsai Tsai-Miao Shih Theodore Tsai Jhe-Wei Hu Yi-An Lai Jui-Fu Hsiao Guochuan Emil Tsai Department of Research and Development, SyneuRx International (Taiwan) Corp., 20F-8, No. 99, Sec. 1, Xintai 5th Rd., Xizhi District, New Taipei City 221, Taiwan Department of Psychiatry and

• warrants further investigation for the development of CNS therapeutics. Nanocrystals play an important role in pharmaceutic design and development. The properties of nanocrystals are remarkably different from their bulk material counterpart, attributed to the large surface-area-to-volume ratio which can

• showed good performance in the Franz diffusion test and rodent pharmacokinetic studies due to the nanoparticle size and faster dissolution as compared with the commercial DCS powder. These DCS nanocrystal formulations could offer a new approach for the development of an advanced drug delivery system for

Heat-induced morphological changes in silver nanowires deposited on a patterned silicon substrate

• Elyad Damerchi,
• Sven Oras,
• Edgars Butanovs,
• Allar Liivlaid,
• Mikk Antsov,
• Boris Polyakov,
• Annamarija Trausa,
• Veronika Zadin,
• Andreas Kyritsakis,
• Loïc Vidal,
• Karine Mougin,
• Siim Pikker and
• Sergei Vlassov

Beilstein J. Nanotechnol. 2024, 15, 435–446, doi:10.3762/bjnano.15.39

• Development Fund project Nr. 1.1.1.1/21/A/053 realized at the Institute of Solid State Physics, University of Latvia. The Institute of Solid State Physics, University of Latvia, as the Center of Excellence has received funding from the European Union's Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016

Potential of a deep eutectic solvent in silver nanoparticle fabrication for antibiotic residue detection

• Le Hong Tho,
• Bui Xuan Khuyen,
• Ngoc Xuan Dat Mai and
• Nhu Hoa Thi Tran

Beilstein J. Nanotechnol. 2024, 15, 426–434, doi:10.3762/bjnano.15.38

• ], and other analytical measurements regarding food, medical, and environmental issues [12][13][14]. Undeniably, SERS is the future for sensor design. So far, most achievements regarding SERS rely on the development of plasmonic materials. Noble metals (e.g., Au, Ag, and Cu) are the most important group

• biosensors are commonly made of LSPR materials [17]. With the development of synthesis techniques, numerous nanostructures of noble metals have been extensively studied to improve the intrinsic parameters of sensors. Silver nanoparticles (Ag NPs) exhibit great performance in sensing applications owing to the

• presence of the fcc Ag lattice planes, we claim that Ag NPs-DES have been successfully synthesized [41]. The development of clusters into nanoparticles following our strategy is supported by the DES. DESs have been reported to be potential shape-controlling agents, and highly branched nanostructures were