Beilstein J. Nanotechnol.2015,6, 111–123, doi:10.3762/bjnano.6.11
, Germany Institute of Physical Chemistry and Electrochemistry, Technical University of Dresden, Bergstr. 66b, 01069 Dresden, Germany 10.3762/bjnano.6.11 Abstract 51Cr-labeled, superparamagnetic, iron oxide nanoparticles (51Cr-SPIOs) and 65Zn-labeled CdSe/CdS/ZnS-quantum dots (65Zn-Qdots) were prepared
uptake, although the 65Zn-label appeared not to be fully stable. As the degradation of the nanoparticles takes place, the individual transport mechanisms for the different isotopes must be carefully taken into account. Although this variation in transport paths can bring new insights with regard to the
sensitivity for the first time. After intravenous injection, polymer-coated, 65Zn-Qdots were mainly taken up by the liver and spleen, which was different from that of ionic 65ZnCl2. Following the label for 4 weeks, an indication of substantial degradation of the nanoparticles and the release of the label into
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Figure 1:
Postsynthetic labeling of quantum dots or SPIOs by incubation of monodisperse, oleic acid-stabilize...
Beilstein J. Nanotechnol.2014,5, 2383–2387, doi:10.3762/bjnano.5.247
phase transfer of the QDs.
Keywords: biomarker; CdSe/CdS/ZnS; quantum dots; radioactive labelling; 65Zn; Introduction
Two decades of research and investigation in the field of luminescent semiconductor nanoparticles, also known as quantum dots (QDs), have now passed since the fundamental work of
present in the synthesis with their equivalent radionuclides. In the past, radionuclides such as 109Cd or 111In were used for intrinsic radiolabeling [12][13]. In this work, the Zn component of CdSe/CdS/ZnS core/shell/shell QDs was selected for replacement with 65Zn due to its ease of availability
. Furthermore, due to the frequency with which ZnS is used as a shell material, the selection of 65Zn allows the variation of the core, offering a higher degree of versatility for the method.
The well-investigated CdSe-based QDs were utilised as a model system onto which CdS and ZnS are coated via the
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Figure 1:
(A) Principle steps in the QD synthesis starting with the CdS coating of CdSe QDs and followed by s...