Beilstein J. Nanotechnol.2022,13, 82–95, doi:10.3762/bjnano.13.6
delivery of an anionic cargo. Besides, a strong intracellular optical signal supports the optically traceable nature of these nanoparticles. SPION@bPEI nanoparticles were further conjugated with Erbitux (Erb), which is an anti-EGFR antibody for targeting EGFR-overexpressing cancer cell lines. SPION@bPEI
selective uptake and hence the targeting ability of Erb-tagged nanoparticles. Altogether, this study proves luminescent, cationic, and small SPION@bPEI nanoparticles as strong candidates for imaging and gene therapy.
Keywords: Erbitux; photoluminescence; polyethyleneimine; polyinosinic–polycytidylic acid
therapeutic dose. Next, SPION@bPEI were conjugated with Erbitux (Erb), which is an anti-EGFR antibody for targeting EGFR-overexpressing cancer cell lines. Finally, SPION@bPEI-Erb nanoparticles were used for the targeted delivery of a GFP plasmid, whose transfection can be confirmed with the luminescence of
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Figure 1:
a) TEM image of SPION@bPEI. b) AFM micrograph image of SPION@bPEI (magnetic mode). c) X-ray diffrac...