Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• the treatment of CNS disorders. Keywords: ᴅ-cycloserine; drug delivery system; enteric capsules; N-methyl-ᴅ-aspartate; nanocrystals; NMDA receptor agonist; transdermal reservoir; Introduction Tuberculosis (TB) is a prevalent respiratory disease caused by Mycobacterium tuberculosis. According to the

pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• drug and nanoparticle uptake in macrophage cells in vitro, as macrophages are the primary site of infection for many intracellular pathogens including Mycobacterium [31]. Results and Discussion Iron oxide nanoparticles were successfully synthesized, indicated by the appearance of a black coloration

• upon addition of ammonia solution (Figure 1). NOR was loaded onto the IONPs at pH 5 or pH 10 and the nanoparticles were subsequently analyzed. It was noted that the efficacy of NOR against Mycobacterium smegmatis remained unaffected by a change of pH, to either pH 5 or pH 10 (Supporting Information

• the intracellular drug concentration in macrophages (having engulfed pathogens, like Mycobacterium) results in high drug dosage requirement for the pathogen clearance. This is a major hurdle in tuberculosis treatment. In turn, a high dosage causes toxic side effects from either the drug or the carrier

Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

• Gennady L. Burygin,
• Polina I. Abronina,
• Nikita M. Podvalnyy,
• Sergey A. Staroverov,
• Leonid O. Kononov and
• Lev A. Dykman

Beilstein J. Nanotechnol. 2020, 11, 480–493, doi:10.3762/bjnano.11.39

• and evaluate in vivo glyco-gold nanoparticles (glyco-GNPs) bearing the terminal-branched hexaarabinofuranoside fragment (Ara6) of arabinan domains of lipoarabinomannan and arabinogalactan, which are principal polysaccharides of the cell wall of Mycobacterium tuberculosis, the causative agent of

• suggest that glyco-GNPs are promising agents for the generation of anti-mycobacterial antibodies. Keywords: conjugation of glycosides; gold nanoparticles; lipoarabinomannan; Mycobacterium; spacer aglycon; Introduction A number of bacterial glycans [1][2] are specific markers for the detection and the

• Burkolderia mallei [42] have been shown to be promising vaccine candidates. Tuberculosis (TB), which is caused by the pathogenic bacterial species Mycobacterium tuberculosis, remains one of the ten most common causes of death worldwide. Nearly two million people die from the disease every year [59][60][61][62

False positives and false negatives measure less than 0.001% in labeling ssDNA with osmium tetroxide 2,2’-bipyridine

• Anastassia Kanavarioti

Beilstein J. Nanotechnol. 2016, 7, 1434–1446, doi:10.3762/bjnano.7.135

• applications [8][9][10]. The advantage of protein pores is that they are well defined and highly reproducible, whereas the advantage of solid-state nanopores is that they can be manufactured to desirable dimensions. Protein pores such as α-HL, a modified version of the Mycobacterium smegmatis porin A (MspA

Preparation of alginate–chitosan–cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds

• Albert Ivancic,
• Fliur Macaev,
• Fatma Aksakal,
• Veaceslav Boldescu,
• Serghei Pogrebnoi and
• Gheorghe Duca

Beilstein J. Nanotechnol. 2016, 7, 1208–1218, doi:10.3762/bjnano.7.112

• aminoglutethimide [27]. We have suggested that isoconazole is an active inhibitor of enoyl–acyl carrier protein reductase (InhA) from M. tuberculosis. InhA is one of the key enzymes involved in the fatty acid biosynthesis of the mycobacterium and is an effective antimicrobial target. InhA inhibitors are promising

Single pyrimidine discrimination during voltage-driven translocation of osmylated oligodeoxynucleotides via the α-hemolysin nanopore

• Yun Ding and
• Anastassia Kanavarioti

Beilstein J. Nanotechnol. 2016, 7, 91–101, doi:10.3762/bjnano.7.11

• such as the α-HL, a modified version of the Mycobacterium smegmatis porin A (MspA), and the Ph29 connector channel have been investigated as single molecule sensing devices for ssDNA, RNA, dsDNA, and proteins [12][13][14]. The advantage of the natural pores is that they are well defined and highly

Nanoscopic surfactant behavior of the porin MspA in aqueous media

• Ayomi S. Perera,
• Hongwang Wang,
• Tej B. Shrestha,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2013, 4, 278–284, doi:10.3762/bjnano.4.30

• ; hydrophobic interaction; liposome-type cluster; protein cluster; supramolecular; temperature influence; zeta potential; Introduction The homo-octameric porin MspA from Mycobacterium smegmatis is one of the most stable proteins known to date [1]. Due to its size and unique structure [2], its resistance to

Magnetic nanoparticles for biomedical NMR-based diagnostics

• Huilin Shao,
• Tae-Jong Yoon,
• Monty Liong,
• Ralph Weissleder and
• Hakho Lee

Beilstein J. Nanotechnol. 2010, 1, 142–154, doi:10.3762/bjnano.1.17

• , the highly magnetic Fe-core/ferrite shell nanoparticles (CB; cannonballs) were used in combination with the second generation DMR device [16]. To evaluate the clinical utility of the DMR platform for TB detection, Bacillus Calmette-Guérin (BCG), used as a surrogate for Mycobacterium tuberculosis, was