Beilstein J. Nanotechnol.2017,8, 2729–2740, doi:10.3762/bjnano.8.272
chemotherapy for the treatment of peritoneal carcinomatosis. However, recent reports reveal limitations of the currently available technology.
Material and Methods: A novel approach for pressurised intraperitoneal aerosol chemotherapy (PIPAC), called hyperthermic intracavitary nanoaerosol therapy (HINAT
spectrometry, scintigraphic peritoneography and fluorescence microscopy. All experiments were performed contemporaneous with conventional PIPAC for the purpose of comparison. Furthermore, a first proof of concept was simulated in anesthetised German Landrace pigs.
Results: HINAT provides a nanometre-sized (63
nm) unipolar-charged hyperthermic (41 °C) drug aerosol for quasi uniform drug deposition over the whole peritoneum with significantly deeper drug penetration than that offered by conventional PIPAC.
Keywords: HINAT; intracavitary; intraperitoneal; nanoaerosol; PIPAC; pressurized; therapy
PDF
Figure 1:
Schematic illustration of the HINAT approach; CAWS = closed air waste system, HEPA = high efficienc...