Manufacturing and investigation of physical properties of polyacrylonitrile nanofibre composites with SiO₂, TiO₂ and Bi₂O₃ nanoparticles

• Tomasz Tański,
• Wiktor Matysiak and
• Barbara Hajduk

Beilstein J. Nanotechnol. 2016, 7, 1141–1155, doi:10.3762/bjnano.7.106

• acid) (PLA), poly(butylene succinate) (PBS), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), poly(vinylidene difluoride) (PVBF), poly(vinylpyrrolidone) PVP, poly(acrylonitrile) (PAN)) reinforced with particles of SiO2, TiO2 and Bi2O3, particularly in thin layers, are very attractive because of

Fabrication and characterization of novel multilayered structures by stereocomplexion of poly(D-lactic acid)/poly(L-lactic acid) and self-assembly of polyelectrolytes

• Elena Dellacasa,
• Li Zhao,
• Gesheng Yang,
• Laura Pastorino and
• Gleb B. Sukhorukov

Beilstein J. Nanotechnol. 2016, 7, 81–90, doi:10.3762/bjnano.7.10

• aliphatic polyester poly(lactic acid) (PLA) has been widely used in the biomedical field due to its extraordinary biocompatibility, biodegradability and mechanical properties [19][30][31][32][33]. Lactic acid, which is the degraded product from PLA, is fully biocompatible in human bodies, and therefore

• medical materials made from PLA, such as surgical suture, implants, as well as drug carriers, are in high demand. Recently PLA-based polymers have been used for the fabrication of drug carriers by a LBL self-assembly technique [15][17][34]. As an example, the stepwise assembly of poly(L-lactic acid) (PLLA

• ) and poly(D-lactic acid) (PDLA) enantiomers, forming a racemic crystal called a stereocomplex, has been successfully realized [35]. However, PLA capsules made by the LBL technique with an entirely biocompatible procedure remain a challenge [36][37][38]. The possibility to assemble these polymers, as

Fabrication of hybrid nanocomposite scaffolds by incorporating ligand-free hydroxyapatite nanoparticles into biodegradable polymer scaffolds and release studies

• Balazs Farkas,
• Marina Rodio,
• Ilaria Romano,
• Alberto Diaspro,
• Romuald Intartaglia and
• Szabolcs Beke

Beilstein J. Nanotechnol. 2015, 6, 2217–2223, doi:10.3762/bjnano.6.227

• modulus of our rapid prototyping-fabricated scaffolds can be adjusted over a range of four orders of magnitude without any implied modifications concerning the chemical composition of the resin itself. In this study, we present the combination of two laser methods (PLA and MPExSL) to incorporate HA NPs

• methods (PLA and MPExSL) to incorporate hydroxyapatite nanoparticles (HA NPs) into a biodegradable polymer resin. Ligand-free production of NPs can be considered a green route of NP synthesis that is beneficial for biological applications. HA NP release test was performed and showed that a controlled

Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

• Jakub Hrib,
• Jakub Sirc,
• Radka Hobzova,
• Zuzana Hampejsova,
• Zuzana Bosakova,
• Marcela Munzarova and
• Jiri Michalek

Beilstein J. Nanotechnol. 2015, 6, 1939–1945, doi:10.3762/bjnano.6.198

• implants [26]. In present work the PEGs were added to the solutions of polymers and were incorporated in nanofibers made from polycaprolactone (PCL), polylactide (PLA) and polyvinyl alcohol (PVA) during electrospinning. The release behavior of these molecules into the water environment was investigated and

• possible. However, the morphological characterization revealed several differences in the parameters of resultant samples (Table 1). The thinnest fibers with a mean fiber diameter 157 nm were prepared from PVA, and the thickness of PCL nanofibers (179 nm) was almost similar to this value. PLA fibers were

• the thickest, with a diameter of 282 nm. The surface areas corresponded to the fiber diameters; the surface area was largest for the thinnest PVA fibers (7.7 m2/g) and smallest for PLA (4.7 m2/g). These differences are due to the needle-free electrospinning method. Needle-free electrospinning does not

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Maria J. Ramalho,
• Joana A. Loureiro,
• Bárbara Gomes,
• Manuela F. Frasco,
• Manuel A. N. Coelho and
• M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

• biocompatibility, biodegradability, mechanical strength, FDA approval and low synthesis complexity. One of the most attractive candidates is poly(lactic-co-glycolic acid) (PLGA), which is a copolymer of poly(lactic acid) (PLA) and poly(glycolic acid) (PGA) [18][19]. We expect that vitamin D3 encapsulation in these

• therapy [22]. A few years later, Almouazen et al. developed a formulation using PLA nanoparticles of about 200 nm [14]. This study proved that PLA nanocapsules are a suitable choice for controlled delivery of antineoplastic agents, namely the nanoencapsulated calcidiol induced a significant growth

• inhibition when compared to free calcidiol, and the PLA NPs enhanced the intracellular delivery of vitamin in breast cancer cells [14]. In another work, Bonor et al. [23] developed calcitriol-conjugated quantum dots to analyze calcitriol distribution and dynamics in mouse myoblast cells. The authors

Caveolin-1 and CDC42 mediated endocytosis of silica-coated iron oxide nanoparticles in HeLa cells

• Nils Bohmer and
• Andreas Jordan

Beilstein J. Nanotechnol. 2015, 6, 167–176, doi:10.3762/bjnano.6.16

• human alveolar epithelial cells and polystyrene nanoparticles around 100 nm [38] as well as polymer coated gold nanoparticles with a core size around 13 nm [39]. On the other hand there are studies showing the uptake of different nanoparticles by HeLa cells such as quantum dots [35], PEG-PLA particles

• compared to the control cells (Figure 5, Figure 6). This points to a possible compensatory upregulation of other endocytotic mechanisms, as it was shown for HeLa cells [41] as well as for MDCK and HeLa cells incubated with PEG-PLA nanoparticles [37][42]. Involvement of Caveolin-1, Flotillin-1, Clathrin and

Interaction of dermatologically relevant nanoparticles with skin cells and skin

• Annika Vogt,
• Fiorenza Rancan,
• Sebastian Ahlberg,
• Berouz Nazemi,
• Chun Sik Choe,
• Maxim E. Darvin,
• Sabrina Hadam,
• Ulrike Blume-Peytavi,
• Kateryna Loza,
• Jörg Diendorf,
• Matthias Epple,
• Christina Graf,
• Eckart Rühl,
• Martina C. Meinke and
• Jürgen Lademann

Beilstein J. Nanotechnol. 2014, 5, 2363–2373, doi:10.3762/bjnano.5.245

• cell culture conditions are not always predictive for ex vivo or in vivo tissue studies. For example, in previous studies on skin interactions with biodegradable poly(lactic acid) (PLA) particles loaded with different fluorescent dyes, we found that although mono-dispersed and stable in aqueous

Antimicrobial nanospheres thin coatings prepared by advanced pulsed laser technique

• Alina Maria Holban,
• Valentina Grumezescu,
• Alexandru Mihai Grumezescu,
• Bogdan Ştefan Vasile,
• Roxana Truşcă,
• Rodica Cristescu,
• Gabriel Socol and
• Florin Iordache

Beilstein J. Nanotechnol. 2014, 5, 872–880, doi:10.3762/bjnano.5.99

• -chitosan-magnetite-eugenol (PLA-CS-Fe3O4@EUG) nanospheres by matrix assisted pulsed laser evaporation (MAPLE). Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) investigation proved that the homogenous Fe3O4@EUG nanoparticles have an average diameter of about 7 nm, while the PLA

• materials [37], metaloporphyrines [38] and for biomolecules, e.g., poly(lactic acid) (PLA) [39], poly(lactic-co-glycolic acid) PLGA [40], polyvinyl alcohol (PVA) [41] and fibrinogen [42]. Our recent reports have highlighted the capability of the laser processing technique to prepare thin coatings based on

• in the micrometric range. The average diameter of PLGA–PVA, PLGA–PVA–BSA (bovine serum albumin) and PLGA–PVA–CS particles ranged from 180 to 250 nm. Grumezescu et al., [34], reported the MAPLE fabrication of PLA–PVA–UA microsphere thin coatings. These thin coatings possessed a homogeneous shape and