Nanoparticles based on the zwitterionic pillar[5]arene and Ag⁺: synthesis, self-assembly and cytotoxicity in the human lung cancer cell line A549

• Dmitriy N. Shurpik,
• Denis A. Sevastyanov,
• Pavel V. Zelenikhin,
• Pavel L. Padnya,
• Vladimir G. Evtugyn,
• Yuriy N. Osin and
• Ivan I. Stoikov

Beilstein J. Nanotechnol. 2020, 11, 421–431, doi:10.3762/bjnano.11.33

• signals, which indirectly indicates the aggregation process and the formation of 3/Ag+ associates [34][35][36]. Therefore, we used the 2D 1H,1H-nuclear Overhauser effect spectroscopy (NOESY) NMR methods (Figure 3), 2D 1H,1H-rotational frame nuclear Overhauser effect spectroscopy (ROESY) NMR and 2D

• the case of macrocycle 4. The obtained results are in good agreement and confirmed by the 2D 1H,1H-ROESY NMR spectroscopy. 2D ROESY NMR spectroscopy is one of the most effective tools for the study of inter- and intramolecular interactions of complex systems. The presence of cross peaks generated by

• nuclear Overhauser effects (NOE) between spatially close protons gives useful information about the dynamics and averaged relative inter/intramolecular proton distances of these particles within 0.4 nm in solution [37][38][39]. Н8/Н1, Н8/Н2, Н6/Н2, Н8/Н3 cross peaks are observed in the 2D 1H,1H-ROESY NMR

Association of aescin with β- and γ-cyclodextrins studied by DFT calculations and spectroscopic methods

• Ana I. Ramos,
• Pedro D. Vaz,
• Susana S. Braga and
• Artur M. S. Silva

Beilstein J. Nanotechnol. 2017, 8, 348–357, doi:10.3762/bjnano.8.37

• functional theory (DFT) calculations on the interaction of aescin Ib with CDs show that an inclusion can indeed occur and it is further demonstrated that the wider cavity of γ-CD is more adequate to accommodate this large guest. ROESY spectroscopy is consistent with the formation of a complex in which the

• also occurs with β-CD. The geometry of the γ-CD·aescin complex is characterised by the inclusion of the triterpene segment of aescin into the host cavity. Keywords: aescin; cyclodextrin inclusion; DFT; 1H NMR; ROESY; Introduction Aescin is the main component of the crystalline saponins obtained from

• solution, as denoted by the Job plot, implies that the Kapp values herein presented are only a rough estimate of affinity. Furthermore, the values are within the same order of magnitude, meaning that the affinity of aescin towards these two hosts is not markedly different. ROESY spectrum of γ-CD·aescin The

Cyclodextrin-poly(ε-caprolactone) based nanoparticles able to complex phenolphthalein and adamantyl carboxylate

• Daniela Ailincai and
• Helmut Ritter

Beilstein J. Nanotechnol. 2014, 5, 651–657, doi:10.3762/bjnano.5.76

• covalently attached. The nanoparticles have been characterized in terms of morphology and diameter by both DLS measurements and TEM. Umbelliferone, a hydrophobic molecule, was not included in the cavity of the CD moiety according to ROESY NMR measurements. However, the encapsulation of umbelliferone in the