Beilstein J. Nanotechnol.2017,8, 772–783, doi:10.3762/bjnano.8.80
. In the present work, an elastin-like recombinamer bearing lysine amino acids distributed along the recombinamer chain has been cross-linked via Huisgen [2 + 3] cycloaddition. The recombinamer contains the SNA15 peptide domains inspired by salivary statherin, a peptide epitope known to specifically
biomaterials.
Keywords: calcium phosphate; elastin-like recombinamers; hydroxyapatite; mineralization; SNA15; Introduction
Combination of the specific properties of two materials is often a key to generating a new material, whose properties are superior to those of its individual components, with improved
the combination of ELRs with mineralizing domains to be obtained. One of these mineralization-enhancing segments is the SNA15 (DDDEEKFLRRIGRFG)* peptide from salivary statherin that has negative and positive charges stemmed from the side chains of aspartic (D), glutamic (E), lysine (K) and arginine (R
PDF
Figure 1:
Schematic representation of (A) the H3AH3 recombinamer, (B) azide- (component 1) and cyclooctyne-de...