Chemoselective silicification of synthetic peptides and polyamines

• Maryna Abacilar,
• Fabian Daus and
• Armin Geyer

Beilstein J. Nanotechnol. 2015, 6, 103–110, doi:10.3762/bjnano.6.10

• by 1H NMR. The polyamines 1, 2, and 3 have increasing numbers of 4, 5 and 11 basic nitrogens. Peptide 4 is a simplified sequence derived from the silaffins and bears 6 primary amines. Amino acids are characterized by the one-letter code (S Serin, K Lysin, G Glycin, Y Tyrosine). Toxine 5 is the

Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells

• Heike Sinnecker,
• Katrin Ramaker and
• Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2308–2315, doi:10.3762/bjnano.5.239

• acids representative for an alimentary peptide source, we noticed that this seemed to have no substantial effect on the adherence of NPs to the cells, only with the 20 nm NPs slightly higher fluorescence intensities were measured (Figure 2A). Individual peptides and amino acids of this extract do

• showed that the decrease in fluorescence at the cell surface was not associated with an increased fluorescence inside the cells, indicating that the protein coat had not led to an enhanced NP uptake by the cells. When analyzing the effect of NP treatment with meat extract, a mixture of peptides and amino

Biopolymer colloids for controlling and templating inorganic synthesis

• Laura C. Preiss,
• Katharina Landfester and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2014, 5, 2129–2138, doi:10.3762/bjnano.5.222

• find starch [13][14], different cellulose derivatives [15], dextran [16], pectin [17], alginate [18], and poly(amino acids) or proteins [19][20][21][22][23][24][25][26][27][28][29]. Researchers in the biomineralization field very often extract proteins from biological matter and use them for the ex

• to the surface of colloidal particles. In this sense, Krattiger et al. [44] reported the morphogenesis of CaCO3 and DL-alanine crystals in the presence of polystyrene beads functionalized with synthetic peptides with different amino acids and oligopeptides. B. Biopolymers as “supports” B1. Molecular

Real-time monitoring of calcium carbonate and cationic peptide deposition on carboxylate-SAM using a microfluidic SAW biosensor

• Anna Pohl and
• Ingrid M. Weiss

Beilstein J. Nanotechnol. 2014, 5, 1823–1835, doi:10.3762/bjnano.5.193

• -lysine core (N-EEKKKKKES-C vs N-AKKKKKAS-C) interact with carboxylates on the SAM-biosensor chip surface in a different way. The presence of the glutamic acid residues stabilizes the mode of interaction with the charged surface. When lysine residues are flanked by neutral amino acids, the interaction

Donor–acceptor graphene-based hybrid materials facilitating photo-induced electron-transfer reactions

• Anastasios Stergiou,
• Georgia Pagona and
• Nikos Tagmatarchis

Beilstein J. Nanotechnol. 2014, 5, 1580–1589, doi:10.3762/bjnano.5.170

• to introduce fused pyrrolidine rings into the skeleton of graphene [38]. Azomethine ylides are organic 1,3-dipoles possessing a carbanion next to an iminium ion and can be readily produced upon decarboxylation of the iminium salts derived from the condensation of α-amino acids with aldehydes or

Synthesis of hydrophobic photoluminescent carbon nanodots by using L-tyrosine and citric acid through a thermal oxidation route

• Venkatesh Gude

Beilstein J. Nanotechnol. 2014, 5, 1513–1522, doi:10.3762/bjnano.5.164

• ]. The as-prepared CNDs are hydrophilic in nature. There are some synthetic routes by using citric acid and some surface passivating agents like L-lysine [15], ethanolamine [20], betaine [21] to obtain hydrophilic CNDs through thermal oxidation in air. Amino acids like histidine, arginine, threonine, and

Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

• Dickson Joseph,
• Nisha Tyagi,
• Christian Geckeler and
• Kurt E.Geckeler

Beilstein J. Nanotechnol. 2014, 5, 1452–1462, doi:10.3762/bjnano.5.158

• . Whereas at acidic, neutral and basic pH conditions, different colored dispersions were observed, and detailed studies on their size and shape are in progress. Hence, varying the pH of the protein solution modifies the structural confirmation of the protein, which alters the native state of the amino acids

• , respectively. Based on these results, we speculate that there were no major structural deformations for LYS and HIS. However, OVA and BSA, which are globular proteins, may have unpacked into a linear chain, thereby exposing other amino acids that could absorb in the UV region and thus increasing the UV

• amino acids could be responsible for the formation of AuNPs. The percentage of hydrophobic residues (HR), aromatic residues (ArR), polar residues (PR), acidic residues (AcR), basic residues (BR), and charged residues (CR) contained in each protein was calculated and compared with the intensities of the

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• , which was mainly due to the covalent bonding of the peptide to the surface. FTIR confirmed that the layer was DGEA as several characteristic peaks for DGEA were represented in the ND-DGEA spectrum (Figure 3). Particularly, there were peaks due to C–N stretching in primary or secondary amines of amino

• acids between 1130 and 1390 cm–1, carbonyl stretching in the amide I bonds (1655 cm–1), and NH bending of the primary amine (1544 cm–1). There was also a broadening of the 1544 cm–1 peak (amide II), signifying successful conjugation as additional amide bonds were formed between the carboxyl groups on

Controlling mechanical properties of bio-inspired hydrogels by modulating nano-scale, inter-polymeric junctions

• Seonki Hong,
• Hyukjin Lee and
• Haeshin Lee

Beilstein J. Nanotechnol. 2014, 5, 887–894, doi:10.3762/bjnano.5.101

• quinones. For mussel adhesives, DOPAquinone is formed by oxidation of a catecholic amino acid, 3,4-dihydroxy-L-phenylalanine (DOPA). Subsequently, DOPAquinone rapidly reacts with basic amino acids, such as lysine and/or histidine, forming covalent adducts of DOPA-DOPA, lysyl-DOPA, and/or histeinyl-DOPA [7

Morphological characterization of fullerene–androsterone conjugates

• Alberto Ruiz,
• Margarita Suárez,
• Nazario Martin,
• Fernando Albericio and
• Hortensia Rodríguez

Beilstein J. Nanotechnol. 2014, 5, 374–379, doi:10.3762/bjnano.5.43

• suitably functionalized fullerene derivatives with physical and biological properties interesting for biomedicine and materials science [2]. The covalent linkage of C60 to moieties, such as porphyrins [3], anionic polymethine cyanine [4], and other bioactive molecules such as amino acids [5], peptides [6

Extracellular biosynthesis of gadolinium oxide (Gd₂O₃) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

• Shadab Ali Khan,
• Sanjay Gambhir and
• Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

• absorption edge at ca. 270 nm arises due to electronic transitions in the delocalized π-electrons present in the indole ring of aromatic amino acids such as tryptophan, tyrosine and to some extent phenylalanine residues, which are present in the proteins moiety [24]. These residues of proteins may be

Nanoscopic surfactant behavior of the porin MspA in aqueous media

• Ayomi S. Perera,
• Hongwang Wang,
• Tej B. Shrestha,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2013, 4, 278–284, doi:10.3762/bjnano.4.30

• . Results and Discussion MspA (porin A from M. smegmatis), an octameric channel protein (184 amino acids, Mw = 155,248 Da [20]) is isolated from the outer cell wall of M. smegmatis, a species of nonpathogenic mycobacteria commonly found in soil [21]. The structure of MspA has been studied extensively and

• without denaturation. The MspA-octamer is formed by 160 negatively charged and 64 positively charged amino acids [2]. R165 and E63/E127, as well as R161 and E39, form salt bridges, which greatly stabilize its tertiary structure (R: arginine, E: glutamic acid) [2]. As a result, 136 negatively charged and

• 48 positively charged amino acids are accessible at the surface. Whereas the negative charges are predominantly found within the interior of the “goblet”, positive charges are concentrated in the stem and the periplasmatic loop region of MspA (Figure 1B and Figure 1C). We have investigated the

Distinction of nucleobases – a tip-enhanced Raman approach

• Regina Treffer,
• Xiumei Lin,
• Elena Bailo,
• Tanja Deckert-Gaudig and
• Volker Deckert

Beilstein J. Nanotechnol. 2011, 2, 628–637, doi:10.3762/bjnano.2.66

• orientation of the ring on the gold surface. Similar effects were found to influence the ring breathing mode of aromatic amino acids [31]. Apart from this difference the spectral features can be attributed solely to uracil and no signals of the sugar and phosphate backbone were found. This suggests a strong

Self-organizing bioinspired oligothiophene–oligopeptide hybrids

• Alexey K. Shaytan,
• Eva-Kathrin Schillinger,
• Elena Mena-Osteritz,
• Sylvia Schmid,
• Pavel G. Khalatur,
• Peter Bäuerle and
• Alexei R. Khokhlov

Beilstein J. Nanotechnol. 2011, 2, 525–544, doi:10.3762/bjnano.2.57

• (SPPS) by sequential coupling of standard fluorenylmethoxycarbonyl (Fmoc)-protected amino acids and the pseudoproline unit onto a preloaded TentaGel resin [27]. Incorporation of the Fmoc-protected azido-phenylalanine (aPhe) and the addition of the switch ester segment between valine (Val) and threonine

Electrochemical behavior of dye-linked L-proline dehydrogenase on glassy carbon electrodes modified by multi-walled carbon nanotubes

• Haitao Zheng,
• Leyi Lin,
• Yosuke Okezaki,
• Ryushi Kawakami,
• Haruhiko Sakuraba,
• Toshihisa Ohshima,
• Keiichi Takagi and
• Shin-ichiro Suye

Beilstein J. Nanotechnol. 2010, 1, 135–141, doi:10.3762/bjnano.1.16

• require considerable time for analysis. In recent years, researchers have paid much more attention to the construction of electrochemical enzyme biosensors for the analysis of amino acids [5][6][7], and several electrochemical biosensing systems for L-proline and D-proline determination have been reported

Review and outlook: from single nanoparticles to self-assembled monolayers and granular GMR sensors

• Alexander Weddemann,
• Inga Ennen,
• Anna Regtmeier,
• Camelia Albon,
• Annalena Wolff,
• Katrin Eckstädt,
• Nadine Mill,
• Michael K.-H. Peter,
• Jochen Mattay,
• Carolin Plattner,
• Norbert Sewald and
• Andreas Hütten

Beilstein J. Nanotechnol. 2010, 1, 75–93, doi:10.3762/bjnano.1.10

• hydrophilic. The hydrophilic C-terminal of Mms6 is believed to be the iron binding site [26]. Recent studies within our group showed that nanoparticles can be synthesized in vitro by the use of a shorter synthetic version of the protein Mms6 called c25-mms6. This polypeptide consists of 25 amino acids from