Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• , Spain Department of Organic Chemistry, University of Sevilla, C/ Prof García Gonzalez 1, Sevilla, 41012, Spain Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, 06100, Turkey 10.3762/bjnano.8.145 Abstract Background: Paclitaxel is a potent anticancer drug that

• during chemotherapy. Amphiphilic cyclodextrins are favored oligosaccharides as drug delivery systems for anticancer drugs, having the ability to spontaneously form nanoparticles without surfactant or co-solvents. In the past few years, polycationic, amphiphilic cyclodextrins were introduced as effective

• -cytotoxic against L929 mouse fibroblast cell line. In addition, paclitaxel-loaded nanoparticles have a significant anticancer effect against MCF-7 human breast cancer cell line as compared with a paclitaxel solution in DMSO. Conclusion: According to the results of this study, both amphiphilic cyclodextrin

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• , facilitating chemotherapy administration to prevent recurrence of the tumor at the time of tumor tissue removal by surgical operation. Among the anticancer drugs that are used in clinics, the taxane family of drugs such as paclitaxel and docetaxel are known to be highly effective against a variety of cancer

• often cause serious side effects. Thus, the necessity of a safe and effective formulation and drug delivery approach emerges for these potent anticancer drugs from the taxane family [10][11][12][13]. Successful treatment of brain cancer is dependent on the efficient and safe delivery of chemotherapeutic

• [18][19]. There are several studies reported on PCL as a functional excipients for the preparation of nanoparticulate drug delivery systems with favorable drug loading and release characteristics for hydrophobic anticancer molecules in particular [18][19][20][21]. However, the application of core

Nanoscale isoindigo-carriers: self-assembly and tunable properties

• Tatiana N. Pashirova,
• Andrei V. Bogdanov,
• Lenar I. Musin,
• Julia K. Voronina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Vladimir F. Mironov,
• Lucia Ya. Zakharova,
• Shamil K. Latypov and
• Oleg G. Sinyashin

Beilstein J. Nanotechnol. 2017, 8, 313–324, doi:10.3762/bjnano.8.34

• toxicity as well as to minimize drug degradation and to provide a controllable drug release [51][52][53]. The modification of nanostructures with conjugated π–π fragments leads to the absorption of anticancer drugs via π–π stacking interaction and increases the drug-loading capacity of nanoscale soft

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

• Huijuan Zhang,
• Fuqiang Wu,
• Yazhen Li,
• Xiping Yang,
• Jiamei Huang,
• Tingting Lv,
• Yingying Zhang,
• Jianzhong Chen,
• Haijun Chen,
• Yu Gao,
• Guannan Liu and
• Lee Jia

Beilstein J. Nanotechnol. 2016, 7, 1861–1870, doi:10.3762/bjnano.7.178

• , College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang, 310018, China 10.3762/bjnano.7.178 Abstract In addition to its well-known abortifacient effect, mifepristone (MIF) has been used as an anticancer drug for various cancers in many studies with an in-depth understanding of the

• mechanism of action. However, application of MIF is limited by its poor water solubility and low oral bioavailability. In this work, we developed a drug delivery system based on chitosan nanoparticles (CNs) to improve its bioavailability and anticancer activity. The MIF-loaded chitosan nanoparticles (MCNs

• kinetics demonstrated that MIF was released from CNs in a sustained-release manner. Compared with free MIF, MCNs demonstrated increased anticancer activity in several cancer cell lines. Pharmacokinetic studies in male rats that were orally administered MCNs showed a 3.2-fold increase in the area under the

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• Dorota Matyszewska Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02089 Warsaw, Poland 10.3762/bjnano.7.46 Abstract In this work the interactions of an anticancer drug daunorubicin (DNR) with model thiolipid layers composed of 1,2

• mechanisms proposed to explain the cellular uptake of CNTs including the passive diffusion in a non-invasive manner (tiny nanoneedle mechanism) [18]. Carbon nanotubes have been successfully used to transport different types of anticancer agents including camptothecin, doxorubicin and daunorubicin [19]. The

• agent as the drug in the free form but in the same time they do not influence the organization and properties of the membranes to such extent as the free drug. Conclusion Interactions of anticancer drug daunorubicin with model thiolipid membranes were investigated using Langmuir technique and

Counterion effects on nano-confined metal–drug–DNA complexes

• Nupur Biswas,
• Sreeja Chakraborty,
• Alokmay Datta,
• Munna Sarkar,
• Mrinmay K. Mukhopadhyay,
• Mrinal K. Bera and
• Hideki Seto

Beilstein J. Nanotechnol. 2016, 7, 62–67, doi:10.3762/bjnano.7.7

• (NSAID) for symptomatic relief from rheumatoid arthritis, osteoarthritis and spondylitis [10]. However, the metal-complexes of this molecule form another group of drugs of even greater interest due to their anticancer activity [11][12]. In this context, the attachment of these drugs to DNA molecule gains

Green and energy-efficient methods for the production of metallic nanoparticles

• Mitra Naghdi,
• Mehrdad Taheran,
• Satinder K. Brar,
• M. Verma,
• R. Y. Surampalli and
• J. R. Valero

Beilstein J. Nanotechnol. 2015, 6, 2354–2376, doi:10.3762/bjnano.6.243

• delivery of anticancer drugs have been demonstrated [24][25][26][27][28][29][30][31][32][33][34]. In Table 1, the application of different metallic NPs is summarized. Green Chemistry metrics Green Chemistry is gradually integrated into new scientific and industrial developments to be aligned with the

Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure

• Giovanni N. Roviello,
• Domenica Musumeci,
• Valentina Roviello,
• Marina Pirtskhalava,
• Alexander Egoyan and
• Merab Mirtskhulava

Beilstein J. Nanotechnol. 2015, 6, 1338–1347, doi:10.3762/bjnano.6.138

• innovative biomedical strategies mainly in the field of anticancer therapy. Keywords: nucleopeptides; poly(rA) binders; RNA; self-structures; Review Polyadenylation in RNA processing Polyadenylation is part of the RNA processing pathway that leads to the production of mature mRNA molecules (Figure 1) [1

• following sections for references). Poly(rA) as a target in anticancer approaches As already mentioned, PAP is an enzyme with RNA polymerase activity that specifically incorporates ATP units at the 3’-terminus of mRNA. Typically, the PAP structure comprises three domains surrounding the active site, in

• aberrations in cancer cells [19]. Furthermore, the presence of a specific poly(rA) polymerase overexpressed in cancer cells and, more in general, the enhanced polyadenylation activity found in cancer cells, seem to indicate that poly(rA) is an important candidate for anticancer strategies [20]. Compounds that

Novel ZnO:Ag nanocomposites induce significant oxidative stress in human fibroblast malignant melanoma (Ht144) cells

• Syeda Arooj,
• Samina Nazir,
• Akhtar Nadhman,
• Nafees Ahmad,
• Bakhtiar Muhammad,
• Ishaq Ahmad,
• Kehkashan Mazhar and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2015, 6, 570–582, doi:10.3762/bjnano.6.59

• .6.59 Abstract The use of photoactive nanoparticles (NPs) such as zinc oxide (ZnO) and its nanocomposites has become a promising anticancer strategy. However, ZnO has a low photocatalytic decomposition rate and the incorporation of metal ions such as silver (Ag) improves their activity. Here different

• thus exciting the photosensitizer to produce reactive oxygen species (ROS) such as singlet oxygen (1O2) and hydroxyl radicals (HO•) [6][7]. Photo-oxidation holds promises for the targeted treatment and controlled elimination of cancer cells [8]. ZnO NPs have also shown photo-oxidative anticancer

• photocatalytic decomposition process is slow and needs to be improved [24]. Therefore, it is interesting to enhance their photocatalytic ability and anticancer activity by forming nanocomposites with other materials, including metal ions such as silver (Ag) or iron (Fe) ions [25]. The ZnO:Ag nanocomposites

Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy

• Shanka Walia and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2015, 6, 546–558, doi:10.3762/bjnano.6.57

• synthesis was enhanced by using Y(NO3)3·6H2O and Eu2O3 as reactants, CTAB as surfactant and TEOS as alkyl silicate. Finally, the anticancer drug doxyrubicin (DOX) was loaded into the prepared NPs. Characterization of mesoporous silica NPs (MSN), YVO4:Eu3+ NPs and YVO4-MSNs were done by XRD, FTIR, TEM and

Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes

• Julia M. Tan,
• Jhi Biau Foo,
• Sharida Fakurazi and
• Mohd Zobir Hussein

Beilstein J. Nanotechnol. 2015, 6, 243–253, doi:10.3762/bjnano.6.23

• (anticancer drug) onto the epidermal growth factor functionalized SWCNT [23]. Release behaviour of LD In this study, the release profiles for LD from SWCNT–COOH at PBS pH values of 7.4 and 4.8 were investigated and shown in Figure 5. Both of the release curves show a fast release in the early stage, followed

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• study revealed that platinum-based anticancer drugs preferentially interacted with Al-doped BNNTs as compared to pristine, zigzag and armchair BNNTs [88]. Cisplatin (cis-Pt) and nedaplatin (neda-Pt) molecules were used as platinum-based anticancer drugs. An aluminum (Al) atom is substituted for a boron

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

• Yasuhiko Onishi,
• Yuki Eshita,
• Rui-Cheng Ji,
• Masayasu Onishi,
• Takashi Kobayashi,
• Masaaki Mizuno,
• Jun Yoshida and
• Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

• Hospital, Japan Labour Health and Welfare Organization, 1-10-6 Komei, Minato-ku, Nagoya, Aichi 455-8530, Japan Department of Chemistry, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan 10.3762/bjnano.5.238 Abstract The anticancer efficacy of a supramolecular

• complex is considered to be useful as a drug delivery system (DDS) for anticancer compounds since it formed a stable polymeric micelle in water. The resistance of B16F10 melanoma cells to PTX was shown clearly through a maximum survival curve. Conversely, the DDMC/PTX complex showed a superior anticancer

• efficacy and cell killing rate, as determined through a Michaelis–Menten-type equation, which may promote an allosteric supramolecular reaction to tubulin, in the same manner as an enzymatic reaction. The DDMC/PTX complex showed significantly higher anticancer activity compared to PTX alone in mouse skin

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

• Sebastian Ahlberg,
• Alexandra Antonopulos,
• Jörg Diendorf,
• Ralf Dringen,
• Matthias Epple,
• Rebekka Flöck,
• Wolfgang Goedecke,
• Christina Graf,
• Nadine Haberl,
• Jens Helmlinger,
• Fabian Herzog,
• Frederike Heuer,
• Stephanie Hirn,
• Christian Johannes,
• Stefanie Kittler,
• Manfred Köller,
• Katrin Korn,
• Wolfgang G. Kreyling,
• Fritz Krombach,
• Jürgen Lademann,
• Kateryna Loza,
• Eva M. Luther,
• Marcelina Malissek,
• Martina C. Meinke,
• Daniel Nordmeyer,
• Anne Pailliart,
• Jörg Raabe,
• Fiorenza Rancan,
• Barbara Rothen-Rutishauser,
• Eckart Rühl,
• Carsten Schleh,
• Andreas Seibel,
• Christina Sengstock,
• Lennart Treuel,
• Annika Vogt,
• Katrin Weber and
• Reinhard Zellner

Beilstein J. Nanotechnol. 2014, 5, 1944–1965, doi:10.3762/bjnano.5.205

• inhibition could be very interesting in the development of new anticancer therapies. Since all known drugs that are mutagenic are also capable of inducing SCE, we explored levels of SCE in K1 in cells treated with silver nanoparticles and untreated cells (Figure 13) and found a significant increase in the

Carbon-based smart nanomaterials in biomedicine and neuroengineering

• Antonina M. Monaco and
• Michele Giugliano

Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196

• anticancer drugs and preserving their activity under biological conditions [81][82][83][84]. The affinity of NDs for protein adsorption has been finally utilised to separate recombinant proteins from Escherichia coli [85], resulting not only in a radically faster process than the commonly used purification

Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

• Dickson Joseph,
• Nisha Tyagi,
• Christian Geckeler and
• Kurt E.Geckeler

Beilstein J. Nanotechnol. 2014, 5, 1452–1462, doi:10.3762/bjnano.5.158

• AuNPs are internalized by the cells to a greater level than the negatively charged AuNPs. These AuNPs synthesized with protein coating holds promise as anticancer agents and would help in providing a new paradigm in area of nanoparticles. Keywords: anticancer; cytotoxicity; gold Nanoparticles; pH

• deaths in the modern world. Although significant advances in science and technology have given us a more comprehensive understanding of cancer, the diagnosis and treatment of cancer remain challenging. The inability of many anticancer drugs to reach the specific target sites and their common systemic

• targeted drug and gene delivery [29][30][31]. Hence, MTT assays were used to study the cell viabilities of fibroblasts and cancer cells after treatment with AuNPs to check the cytotoxicity and the anticancer properties of the AuNPs for their future biomedical applications. Results and Discussion Synthesis

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• current standard of care is chemotherapy, which involves the use of toxic anticancer drugs, like doxorubicin (DOX), to treat cancers by inducing apoptosis. DOX has had high success rates with treating prostate cancer [2]. However, it can cause major side effects such as hair loss, nausea [2][3], and

Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating

• Tingjun Lei,
• Alicia Fernandez-Fernandez,
• Romila Manchanda,
• Yen-Chih Huang and
• Anthony J. McGoron

Beilstein J. Nanotechnol. 2014, 5, 313–322, doi:10.3762/bjnano.5.35

• often been correlated to a poor therapeutic outcome, since HIF-1 could circumvent the anticancer drug effect by protecting cells from drug-induced apoptosis [12][13][14]. Moreover, tumor angiogenesis occurs partly by activating the expression of VEGF, which is partially regulated by HIF-1 [15][16][17

Extracellular biosynthesis of gadolinium oxide (Gd₂O₃) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

• Shadab Ali Khan,
• Sanjay Gambhir and
• Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

• were bioconjugated with the chemically modified anticancer drug taxol with the aim of characterizing the role of this bioconjugate in the treatment of cancer. The biosynthesized Gd2O3 nanoparticles were characterized by UV–vis spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD

• extended the work of biosynthesis of Gd2O3 nanoparticles to bioconjugation with taxol. Bioconjugation of taxol with gold and iron oxide nanoparticles has also been reported [15][16]. Taxol is one of the most important anticancer drugs used for breast, ovarian and lung cancers [17][18]. The potent

• anticancer effect of taxol is mainly attributed to its mechanism of action. It stabilizes microtubules by preventing their depolymerization [19][20]. However, taxol is a hydrophobic drug and less specific to certain tumors due to its low solubility in water. To counter these problems, we carried out the

En route to controlled catalytic CVD synthesis of densely packed and vertically aligned nitrogen-doped carbon nanotube arrays

• Slawomir Boncel,
• Sebastian W. Pattinson,
• Valérie Geiser,
• Milo S. P. Shaffer and
• Krzysztof K. K. Koziol

Beilstein J. Nanotechnol. 2014, 5, 219–233, doi:10.3762/bjnano.5.24

• steerable drug carriers for the enhanced penetration of target cells in anticancer therapies [72][73]. Experimental Synthesis. The synthesis setup was composed of a pre-heater, a furnace, a quartz reaction tube, injection pump with a syringe, an inert gas flow-meter and an exhausts purifier. The pre-heater

Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• is converted by carboxylesterase (predominantly in the liver) to its biologically active metabolite SN38 (7-ethyl-10-hydroxycamptothecin) [6][7][8][9]. Although CPT-11 had been approved as an anticancer agent by the US Food and Drug Administration (FDA) in 1997, the use of this prodrug is limited due

• , severe side effects, such as life-threatening diarrhea and neutropenia, have been observed [14][15]. SN38 is a topoisomerase I inhibitor, and it has demonstrated 100- to 1000-fold more cytotoxicity against various cancer cells in vitro than CPT-11 [6]. Despite the excellent anticancer potential, SN38 has

• not been used as an anticancer drug directly in humans due to its inherent poor solubility in any pharmaceutically acceptable media (solubility in water <5 µg/mL). To overcome this disadvantage of SN38, two major basic strategies have been developed. The first strategy is to directly introduce