Breaking barriers: nanosystems to overcome solubility and permeability challenges of second-generation tyrosine kinase inhibitors

• Bhagya Shree,
• Abhishek Sharma,
• Manish Kumar,
• Ruchi Chawla and
• Brahmeshwar Mishra

Beilstein J. Nanotechnol. 2026, 17, 1063–1086, doi:10.3762/bjnano.17.73

• stability, scalability, and feasibility for clinical transition. Keywords: BCS class-IV; bioavailability enhancement; biopharmaceutical limitation; bosutinib; dasatinib; drug delivery system; nanosystems; nilotinib; quality by design; second-generation TKI; Introduction Tyrosine kinases have emerged as

• , and bioavailability challenge of these drugs; neither have proposed, after thorough critical analysis, potential formulations according to the criteria bioavailability enhancement, safety, long-term stability, scale-up readiness, clinical translational potential, and regulatory challenges. This review

• for inclusion. The search strategy used combinations of keywords including “dasatinib nanoformulation”, “bosutinib nanoformulation”, “nilotinib nanoformulation”, “oral bioavailability enhancement”, “TKI-nanoparticles”. Only articles published in English that reported formulation development

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

• bioavailability enhancement are discussed. The objective of this study is to provide a comprehensive theoretical foundation for employing polymers as nanocarriers in oral drug delivery. 2 Polymeric nanoparticles: a viable option for oral administration The biocompatibility and biodegradability of polymers have

Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products

• David Hespeler,
• Sanaa El Nomeiri,
• Jonas Kaltenbach and
• Rainer H. Müller

Beilstein J. Nanotechnol. 2019, 10, 1666–1678, doi:10.3762/bjnano.10.162

• solvent removal) can be industrially realized in a commercial 50 L rotary evaporator. Keywords: amorphous dispersion; bioavailability enhancement; dermal delivery system; rutin; smartPearls; solubility enhancement; Introduction Many interesting active agents in pharma and cosmetics are poorly soluble