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Search for "biomarkers" in Full Text gives 35 result(s) in Beilstein Journal of Nanotechnology.
Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (ELISA)
Beilstein J. Nanotechnol. 2017, 8, 244–253, doi:10.3762/bjnano.8.27
- literature, as published by Ambrosia and co-workers in studying the effect of AuNP complexes in enhanced ELISA for the detection of breast cancer biomarkers [12]. In this work, the authors assessed three different concentrations of AuNP probes (ranging approximately from 1.4 to 0.014 AU) discarding the
A novel electrochemical nanobiosensor for the ultrasensitive and specific detection of femtomolar-level gastric cancer biomarker miRNA-106a
Beilstein J. Nanotechnol. 2016, 7, 2023–2036, doi:10.3762/bjnano.7.193
- ]. The most commonly used tumor markers such as carcinoembryonic antigen (CEA) and cancer antigen 19-9 (CA19-9) have insufficient sensitivity and specificity, thus limiting their application in early diagnosis of GC [3]. Therefore, the establishment of novel strong specific biomarkers with sufficient
- sensitivity is an ideal strategy for improving the early detection of GC and the cure rates for patients. Besides, these biomarkers should be easy to evaluate and reliably associated with clinical outcomes. Discovery of miRNAs and the approval of their role in tumorigenesis along with the development of
- various cancers have presented them as the suitable cancer biomarkers [4]. There is also growing evidence that miRNAs exist not only in cells but also in a variety of body fluids, including blood [5], saliva [6], and urine [7]. Those miRNAs that can be found in bloodstream are called circulatory miRNAs
Fabrication and properties of luminescence polymer composites with erbium/ytterbium oxides and gold nanoparticles
Beilstein J. Nanotechnol. 2016, 7, 630–636, doi:10.3762/bjnano.7.55
- ; polymer nanocomposites; rare-earth oxide nanoparticles; Introduction Rare-earth (RE) ions are widely investigated and applied, e.g., in photonics, as active materials for optical amplification or as biomarkers. Er-doped materials are important for light sources in optoelectronics, especially for the
Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection
Beilstein J. Nanotechnol. 2016, 7, 364–373, doi:10.3762/bjnano.7.33
- always when testing biomarkers, the selection process of the required biospecimens is crucial. Therefore, our next steps will consist in testing our liquid biopsy approach with significantly larger group sizes of stage 0 and I breast cancer patients. Methods Nanoplatform synthesis The synthesis and
Mismatch detection in DNA monolayers by atomic force microscopy and electrochemical impedance spectroscopy
Beilstein J. Nanotechnol. 2016, 7, 220–227, doi:10.3762/bjnano.7.20
- different rigidity of ss- and dsDNA [23][24][25], enabling the ultrasensitive detection of biomarkers [26]. The second strategy exploits the change in capacitance during the hybridization process, measured at the interface between a ssDNA-functionalized gold electrode and the solution in an electrochemical
An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology
Beilstein J. Nanotechnol. 2015, 6, 1978–1999, doi:10.3762/bjnano.6.202
- Information File 4 for an in-depth explanation). The sub-lethal cytotoxicity Assay file template (“a_InvID_cytotoxicity.sub-lethal_Method.xls”) was designed to record data from cell based in vitro assays designed to detect sub-lethal phenomena which might be quantified in terms of changes in key biomarkers
- . For example, oxidative stress and inflammation might be detected via measuring the level of glutathione or various cytokine biomarkers respectively [97]. (These sub-lethal phenomena would not be considered “cytotoxicity” by all researchers [84].) The manner in which this template was designed to
Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles
Beilstein J. Nanotechnol. 2015, 6, 1840–1852, doi:10.3762/bjnano.6.187
- concentrations of, e.g., biologically active analytes and disease-related biomarkers [9][10]. Many electrochemical biosensors use ferrocene to transduce the biological reactions into readily measurable electrical signals [11][12]. For instance, Chen and Diao developed a glucose biosensor using gold nanoparticles
- . prepared a nanocomposite consisting of reduced graphene oxide hybridized with electrochemically co-reduced gold nanoparticles and ferrocene as a sensitive immunosensor of breast cancer biomarkers [14]. Very recently, Mars et al. showed that the aggregation of gold nanoparticles through a ferrocene-based
Effect of silver nanoparticles on human mesenchymal stem cell differentiation
Beilstein J. Nanotechnol. 2014, 5, 2058–2069, doi:10.3762/bjnano.5.214
- -dependent manner, whereas chondrogenic differentiation was unaffected after 21 d of incubation. In contrast to aggrecan, the inhibitory effect of adipogenic and osteogenic differentiation was confirmed by a decrease in the secretion of specific biomarkers, including adiponectin (adipocytes) and osteocalcin
- microscopy, photometry and by analyzing the secretion of typical biomarkers. Results Uptake and intracellular distribution of nano-silver in hMSCs Human MSCs were cultured in the presence of 20 µg·mL−1 Ag-NP at 37 °C for 24 h under cell culture conditions, and the cell nucleus and endo-lysosomes were labeled
- genes and proteins is also expected to be attenuated in MSCs upon nanoparticle treatment [48]. This was confirmed in our study by the decreased secretion of specific biomarkers, including adiponectin (adipocytes) and osteocalcin (osteoblasts). Liu et al. also used PCR to analyze osteocalcin expression
Injection of ligand-free gold and silver nanoparticles into murine embryos does not impact pre-implantation development
Beilstein J. Nanotechnol. 2014, 5, 677–688, doi:10.3762/bjnano.5.80
- only one study reported embryotoxic effects of gold clusters after application of a tremendously high dose (1014 NP/embryo) [15]. Thus, our findings confirm the presumption that gold nanoparticles are highly biocompatible and can safely be developed for biomedical applications, such as novel biomarkers
Magnetic nanoparticles for biomedical NMR-based diagnostics
Beilstein J. Nanotechnol. 2010, 1, 142–154, doi:10.3762/bjnano.1.17
- School, 200 Longwood Av, Alpert 536, Boston, MA 02115, U.S.A. 10.3762/bjnano.1.17 Abstract Rapid and accurate measurements of protein biomarkers, pathogens and cells in biological samples could provide useful information for early disease diagnosis, treatment monitoring, and design of personalized
- ; nuclear magnetic resonance; Introduction Rapid and sensitive measurement of clinically relevant biomarkers, pathogens and cells in biological samples would be invaluable for disease diagnosis, monitoring of malignancy, and for evaluating therapy efficacy in personalized medicine. To translate such
- with reduced sample preparation. In contrast, traditional detection strategies based on optical techniques, for example, are often affected by scattering, absorption, autofluorescence, and require extensive sample purification before measurements can be made. To detect biomarkers using MNPs, several
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