Tip-enhanced Raman spectroscopic imaging of patterned thiol monolayers

• Johannes Stadler,
• Thomas Schmid,
• Lothar Opilik,
• Phillip Kuhn,
• Petra S. Dittrich and
• Renato Zenobi

Beilstein J. Nanotechnol. 2011, 2, 509–515, doi:10.3762/bjnano.2.55

• surfaces or certain surface areas. Here, selected areas on a gold surface were modified by a thiol and, in a second step, the remaining substrate was covered by a secondary thiol film. This type of surface can act as a basis for biosensors [12][13]. To produce patterned SAM structures on a gold surface

Towards multiple readout application of plasmonic arrays

• Dana Cialla,
• Karina Weber,
• René Böhme,
• Uwe Hübner,
• Henrik Schneidewind,
• Matthias Zeisberger,
• Roland Mattheis,
• Robert Möller and
• Jürgen Popp

Beilstein J. Nanotechnol. 2011, 2, 501–508, doi:10.3762/bjnano.2.54

• reporter molecules. This work contributes to the development of the more flexible usage of different optical detection schemes on the same chip surface. Results and Discussion The work presented in the following reports on the design and application of biosensors based on periodically patterned plasmonic

Characterization of protein adsorption onto FePt nanoparticles using dual-focus fluorescence correlation spectroscopy

• Pauline Maffre,
• Karin Nienhaus,
• Faheem Amin,
• Wolfgang J. Parak and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2011, 2, 374–383, doi:10.3762/bjnano.2.43

• issue for various fields including biotechnology (e.g., biosensors, bioanalytics) and biomedical devices (e.g., implants and catheters). To be able to control the biological effects of NPs, such as prevention of uptake or targeted delivery to specific cells or tissues, it is of utmost importance to

Magnetic nanoparticles for biomedical NMR-based diagnostics

• Huilin Shao,
• Tae-Jong Yoon,
• Monty Liong,
• Ralph Weissleder and
• Hakho Lee

Beilstein J. Nanotechnol. 2010, 1, 142–154, doi:10.3762/bjnano.1.17

• more effective magnetic nanoparticle biosensors, DMR detection limits for various target moieties have been considerably improved over the last few years. Already, a library of magnetic nanoparticles has been developed, in which a wide range of targets, including DNA/mRNA, proteins, small molecules

• , however, are faster and simpler since the analytical signal is generated from the entire sample volume. By developing optimized MNPs, DMR detection sensitivities for various target moieties have been considerably improved. To date, numerous magnetic biosensors have been designed to identify and quantify a

• bovine serum albumin (BSA) protein as a control did not elicit any change in T2 (Figure 5b). More recently, MRSw biosensors, capable of detecting soluble tumor biomarker proteins (such as CA-125, VEGF, and α-fetoprotein) were described, and used for parallel detection of multiple markers in blood samples

Electrochemical behavior of dye-linked L-proline dehydrogenase on glassy carbon electrodes modified by multi-walled carbon nanotubes

• Haitao Zheng,
• Leyi Lin,
• Yosuke Okezaki,
• Ryushi Kawakami,
• Haruhiko Sakuraba,
• Toshihisa Ohshima,
• Keiichi Takagi and
• Shin-ichiro Suye

Beilstein J. Nanotechnol. 2010, 1, 135–141, doi:10.3762/bjnano.1.16

• require considerable time for analysis. In recent years, researchers have paid much more attention to the construction of electrochemical enzyme biosensors for the analysis of amino acids [5][6][7], and several electrochemical biosensing systems for L-proline and D-proline determination have been reported

• [8][9]. In the construction of enzyme biosensors, efficient communication between the active site of enzyme molecule and the electrode surface is one of the most important factors for sensor performance. As the protein shell always prevents the direct electron transfer from the active site of the

• enzyme, specific immobilization strategies, including electron mediators, should be considered [10][11][12]. In the last decade, the use of nano materials, especially carbon nanotubes (CNTs), in the construction of enzyme biosensors has received considerable attention. Because of their excellent