Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions

• Da Shi,
• Justine Wallyn,
• Dinh-Vu Nguyen,
• Francis Perton,
• Delphine Felder-Flesch,
• Sylvie Bégin-Colin,
• Mounir Maaloum and
• Marie Pierre Krafft

Beilstein J. Nanotechnol. 2019, 10, 2103–2115, doi:10.3762/bjnano.10.205

• ), University of Strasbourg, 23 rue du Loess, 67034 Strasbourg, France 10.3762/bjnano.10.205 Abstract Dendrons fitted with three oligo(ethylene glycol) (OEG) chains, one of which contains a fluorinated or hydrogenated end group and bears a bisphosphonate polar head (CnX2n+1OEG8Den, X = F or H; n = 2 or 4

• have been investigated for hyperthermia and magnetic resonance imaging owing to their increased stability in aqueous media and biocompatibility [27][28]. An even stronger anchoring agent consisting of a dendron structure bearing a bisphosphonate polar head provided increased colloidal stability in

• , and allowing the microbubbles to go undetected, thus potentially minimizing the recourse to pegylated lipids. We report here the preparation of perfluorohexane (F-hexane)-stabilized MBs with a shell of dipalmitoylphosphatidylcholine (DPPC) that incorporates IONPs grafted with OEG bisphosphonate-headed

Targeting strategies for improving the efficacy of nanomedicine in oncology

• Gonzalo Villaverde and
• Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

• . In 2017, Villaverde et al. [80] described a double sequential encrypted targeting system focused on bone tumour. Bone is usually poorly irrigated and nanoparticles have serious difficulties to reach this tissue. The system is based on a hybrid peptide/polymeric chain that contains a bisphosphonate

Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment

• Anouchka Plan Sangnier,
• Romain Aufaure,
• Laurence Motte,
• Claire Wilhelm,
• Erwann Guenin and
• Yoann Lalatonne

Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273

• with the same molecule used as reductant, coating and therapeutic agent has been developed in a one-pot, one-phase process using alendronate, a drug from the bisphosphonate family known for its antitumor effects. In addition, the core made of gold nanoparticles (NPs) brings thermal functionalities

• , with an IC50 value of 100 µM. Under NIR irradiation a temperature increase was observed leading to a reduction of the IC50 value to 1 µM, with total tumor cell death at 100 µM. Keywords: alendronate; bisphosphonate; cancer treatment; gold nanoparticles; photothermia; Findings Bisphosphonates (BPs

• phosphonate groups. The BP affinity for calcium is improved by adding a hydroxy (–OH) group, for instance in HMBP (hydroxylmethylene bisphosphonate), allowing for a tridentate coordination to Ca2+ ions (Supporting Information File 1, Figure S4) and leading to a high affinity to bone (hydroxyapatite (Ca10(PO4

Self-assembled anchor layers/polysaccharide coatings on titanium surfaces: a study of functionalization and stability

• Ognen Pop-Georgievski,
• Dana Kubies,
• Josef Zemek,
• Neda Neykova,
• Roman Demianchuk,
• Eliška Mázl Chánová,
• Miroslav Šlouf,
• Milan Houska and
• František Rypáček

Beilstein J. Nanotechnol. 2015, 6, 617–631, doi:10.3762/bjnano.6.63

• anchoring layers of self-assembled bisphosphonate neridronate monolayers and polymer films of 3-aminopropyltriethoxysilane and biomimetic poly(dopamine). These were further used to bind a bio-functional alginate coating. The success of the titanium surface activation, anchoring layer formation and alginate

• bearing phosphonate [14][26][27] and bisphosphonate (BP) [28][29] groups. Upon hydrolysis, these form strong mono- and bi-dentate coordination bonds with metal surfaces [30]. Inspired by the composition of mussel adhesive proteins, Messersmith et al. [31] proposed the formation of poly(dopamine) (PDA

• controlled cell adhesion [37]. The presence of amine groups in PDA has been used for functionalization with moieties for photo-induced grafting reactions [38][39]. In this work, we study the immobilization of three compounds to the titanium surface: bisphosphonate neridronate, APTES and PDA. The neridronate