Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

• Mohammad J. Akbar,
• Pâmela C. Lukasewicz Ferreira,
• Melania Giorgetti,
• Leanne Stokes and
• Christopher J. Morris

Beilstein J. Nanotechnol. 2019, 10, 2553–2562, doi:10.3762/bjnano.10.246

• Mohammad J. Akbar Pamela C. Lukasewicz Ferreira Melania Giorgetti Leanne Stokes Christopher J. Morris School of Pharmacy, University of East Anglia, Norwich, UK 10.3762/bjnano.10.246 Abstract Background: Gastrin-releasing peptide is a member of the bombesin family of peptides. Its cognate

• targeting has potential for enhancing drug accumulation in resistant cancer cells. Keywords: bombesin; GRPR; liposome; lung cancer; targeting; Introduction Small-cell lung cancer (SCLC) accounts for approximately one in five lung cancer diagnoses. In spite of global efforts to reduce tobacco smoking in

• and give rise to the early SCLC tumours. Of the hormones known to be secreted by SCLC cells, gastrin-releasing peptide (GRP), is the most widely studied. GRP is the human homologue of the amphibian peptide, bombesin, and plays a role in embryonic development and adult repair of bronchial epithelia [3