In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics

• Wolfgang G. Kreyling,
• Stefanie Fertsch-Gapp,
• Martin Schäffler,
• Blair D. Johnston,
• Nadine Haberl,
• Christian Pfeiffer,
• Jörg Diendorf,
• Carsten Schleh,
• Stephanie Hirn,
• Manuela Semmler-Behnke,
• Matthias Epple and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1699–1711, doi:10.3762/bjnano.5.180

• the brain increased even 100-fold while the retention of apolipoprotein-E–AuNP conjugates in the brain was still 10-fold when compared to citrate-stabilized AuNP of the same size. Similarly, retention of both protein–AuNP conjugates was also increased 10-fold in the remaining carcass consisting of

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

• Markus Heine,
• Alexander Bartelt,
• Oliver T. Bruns,
• Denise Bargheer,
• Artur Giemsa,
• Barbara Freund,
• Ludger Scheja,
• Christian Waurisch,
• Alexander Eychmüller,
• Rudolph Reimer,
• Horst Weller,
• Peter Nielsen and
• Joerg Heeren

Beilstein J. Nanotechnol. 2014, 5, 1432–1440, doi:10.3762/bjnano.5.155

• ]. The F4/80 (encoded by Emr1) molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages or brain microglia [36]. Two days after clodronate treatment, Emr1 expression was undetectable

Influence of the PDMS substrate stiffness on the adhesion of Acanthamoeba castellanii

• Sören B. Gutekunst,
• Carsten Grabosch,
• Alexander Kovalev,
• Stanislav N. Gorb and
• Christine Selhuber-Unkel

Beilstein J. Nanotechnol. 2014, 5, 1393–1398, doi:10.3762/bjnano.5.152

• in the human body are the eye and the brain, i.e., very soft environments. Thus, our study provides first hints towards the relevance of mechanical aspects for the pathogenicity of eukaryotic parasites. Keywords: acanthamoeba; cell adhesion; elastic substrates; mechanosensing; silicones

• adhere to comparably soft microenvironments in the brain and in the eye. Interestingly, there is no significant difference in the morphology of A. castellanii between PDMS substrates and the positive control substrate. This shows that A. castellanii trophozoites can adhere very well to PDMS without the

• soft substrates, as their main human infection targets, eye and brain, are very soft, with the brain having Young’s moduli of about 1–10 kPa and less [41]. However, the influence of the substrate stiffness on the adhesion of A. castellanii that we observe in our study is not as pronounced as for

Molecular biology approaches in bioadhesion research

• Marcelo Rodrigues,
• Birgit Lengerer,
• Thomas Ostermann and
• Peter Ladurner

Beilstein J. Nanotechnol. 2014, 5, 983–993, doi:10.3762/bjnano.5.112

• complexity of the transcriptome when expressed genes of, e.g., the reproductive organs or the brain are not included. Second, the bioinformatic assembly of such a transcriptome will be facilitated. Third, the costs can be reduced since a higher coverage of bases, i.e., the frequency of how often a base of

Manipulation of isolated brain nerve terminals by an external magnetic field using D-mannose-coated γ-Fe₂O₃ nano-sized particles and assessment of their effects on glutamate transport

• Tatiana Borisova,
• Natalia Krisanova,
• Arsenii Borуsov,
• Roman Sivko,
• Ludmila Ostapchenko,
• Michal Babic and
• Daniel Horak

Beilstein J. Nanotechnol. 2014, 5, 778–788, doi:10.3762/bjnano.5.90

• of Kyiv, 64 Volodymyrska Str, Kiev, Ukraine The Department of Polymer Particles, Institute of Macromolecular Chemistry AS CR, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic 10.3762/bjnano.5.90 Abstract The manipulation of brain nerve terminals by an external magnetic field promises breakthroughs

• characteristics of the glutamatergic neurotransmission were analysed. Using radiolabeled L-[14C]glutamate, it was shown that D-mannose-coated γ-Fe2O3 nanoparticles did not affect high-affinity Na+-dependent uptake, tonic release and the extracellular level of L-[14C]glutamate in isolated rat brain nerve terminals

• nanoparticles (250 µg/mL) moved to an area, in which the magnet (250 mT, gradient 5.5 Т/m) was applied compared to 33.5 ± 3.0% of the control and 48.6 ± 3.0% of samples that were treated with uncoated nanoparticles. Therefore, isolated brain nerve terminals can be easily manipulated by an external magnetic

Grain boundaries and coincidence site lattices in the corneal nanonipple structure of the Mourning Cloak butterfly

• Ken C. Lee and
• Uwe Erb

Beilstein J. Nanotechnol. 2013, 4, 292–299, doi:10.3762/bjnano.4.32

• and retinula cells. The signals detected by thousands of ommatidia are processed neurologically in the brain to form a complete image. The corneal lens incorporates chitin, a long chained semicrystalline natural polysaccharide with a refractive index of about 1.52. It is well known that the outer

Infrared receptors in pyrophilous (“fire loving”) insects as model for new un-cooled infrared sensors

• David Klocke,
• Anke Schmitz,
• Helmut Soltner,
• Herbert Bousack and
• Helmut Schmitz

Beilstein J. Nanotechnol. 2011, 2, 186–197, doi:10.3762/bjnano.2.22

• processed centrally (e.g., by the brain) rather than locally in their respective ganglia of origin [2]. It is suggested that smoke-derived odours and IR information converge on descending brain neurons which, in turn, control and direct flight toward the forest fire. Two genera of jewel beetles (family

Twofold role of calcined hydrotalcites in the degradation of methyl parathion pesticide

• Alvaro Sampieri,
• Geolar Fetter,
• María Elena Villafuerte-Castrejon,
• Adriana Tejeda-Cruz and
• Pedro Bosch

Beilstein J. Nanotechnol. 2011, 2, 99–103, doi:10.3762/bjnano.2.11

• concentrations. The symptoms of MP poisoning include, i.a., reduction of body weight, anemia and decreased brain acetylcholinesterase activity [2][3]. Although the Basel, Rotterdam and Stockholm Conventions [4] have forbidden hazardous pesticides including MP, this pesticide is still used for many corps. MP and