Beilstein J. Nanotechnol.2018,9, 2057–2070, doi:10.3762/bjnano.9.195
a non-toxic amphiphilic calixresorcinarene capable to form nanoconjugates for drug encapsulation, tetraundecylcalixresorcinarene functionalized by methoxy poly(ethylene glycol) chains has been synthesized. The macrocycle obtained is characterized by low hemotoxicity. In aqueous solution it forms
-buffered saline, the micelles of the macrocycle acquire thermoresponsive properties and exhibit a temperature-controlled release of doxorubicin in vitro. The combination of the low toxicity and the encapsulation properties of the obtained calixresorcinarene–mPEG conjugate shows promising potential for the
use as a supramolecular drug-delivery system.
Keywords: calixresorcinarene; drug encapsulation; hemotoxicity; methoxy poly(ethylene glycol); temperature-controlled release; Introduction
One of the acute problems of modern medicinal therapy is the development of novel drug-delivery systems with low
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Scheme 1:
Synthesis of tetraundecylcalix[4]resorcinarene–mPEG conjugate 3.