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Search for "cell cycle" in Full Text gives 34 result(s) in Beilstein Journal of Nanotechnology.
Association of aescin with β- and γ-cyclodextrins studied by DFT calculations and spectroscopic methods
Beilstein J. Nanotechnol. 2017, 8, 348–357, doi:10.3762/bjnano.8.37
- vivo using xenograft mice, showed cytotoxic effects for aescin, through the induction of apoptosis and G2/M cell cycle arrest [9]. Currently, aescin is mostly employed for venotonic action, being available in the form of topical formulations such as lotions, gels and creams. Many of these products
Nano- and microstructured materials for in vitro studies of the physiology of vascular cells
Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155
- proliferation rate [277]. ECs: Differently regulated genes from cells on microstructures, in comparison to cells on flat surfaces, showed that endothelial cells on microgrooves down-regulated genes related to the cell cycle as well as their gene for β1 integrin [278]. In the future, it would be interesting to
Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms
Beilstein J. Nanotechnol. 2016, 7, 645–654, doi:10.3762/bjnano.7.57
- also internalized by C6 and U373 cells [52]. Valdiglesias et al. [53] found that NPs were internalized by SH-SY5Y neuronal cells exposed to TiO2 NPs, which coincided with alterations in the cell cycle and an elevation in the proportion of apoptotic cells. Damage of the DNA was induced and NO oxidative
- disrupted cell cycle, leading to apoptosis and excessive ROS [63]. Uncertain mechanisms underlying TiO2 NPs-induced neurotoxicity Autophagy Autophagy can be divided into three types, 1) microautophagy, 2) macroautophagy, and 3) identified-chaperone-mediated autophagy. It is believed that macroautophagy
Application of biclustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials
Beilstein J. Nanotechnol. 2015, 6, 2438–2448, doi:10.3762/bjnano.6.252
- black (CB) or carbon nanotubes (CNTs) to determine the disease significance of these data-driven gene sets. Results: Biclusters representing inflammation (chemokine activity), DNA binding, cell cycle, apoptosis, reactive oxygen species (ROS) and fibrosis processes were identified. All of the NM studies
- Genomes (KEGG) pathways were found significant (FDR p-value < 0.05). Ten of the twenty gene symbols from this bicluster were elements of the cell cycle GO (FDR p-value = 4.9 × 10−6) and five were part of the KEGG pathway (FDR p-value = 2.5 × 10−4). The bleomycin injury and the bacterial infection models
- potentially fibrogenic NMs. Although several genes sets associated with acute DNA binding, cell cycle, apoptosis, and ROS response that were specific to different disease models were also observed to be perturbed following exposure to NMs, the implication of such perturbation was not clear from this analysis
PLGA nanoparticles as a platform for vitamin D-based cancer therapy
Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135
- to the free calcitriol results. At this concentration the inhibitory effect on nontumor cells (hTERT-HPNE) decreased to 65%. This study highlights the ability of PLGA nanoparticles to deliver vitamin D3 into cancer cells, with major effects regarding cancer cell cycle arrest and major changes in the
- cell growth, cell cycle arrest and morphological changes. Results Nanoparticle physicochemical properties PLGA NPs were prepared by a single emulsion solvent evaporation method and stabilized with Pluronic®F127. The obtained results for mean the diameter, polydispersity index (PDI) and zeta potential
- form of calcitriol. This was the cell line where the encapsulation of calcitriol in NPs proved to be more advantageous. Cell cycle arrest by calcitriol-loaded PLGA NPs To assess whether the cytotoxic effects of calcitriol are due to cell cycle inhibition, cell cycle analysis by flow cytometry was
Nanoparticle interactions with live cells: Quantitative fluorescence microscopy of nanoparticle size effects
Beilstein J. Nanotechnol. 2014, 5, 2388–2397, doi:10.3762/bjnano.5.248
- (RBCs) can internalize NPs only via passive transport [12]. The efficiency of NP internalization by a cell depends on cell-specific parameters such as cell type or cell cycle phase [13][14] and physicochemical properties of the NP [15]. Notably, NPs with positive surface charge are typically
Interaction of dermatologically relevant nanoparticles with skin cells and skin
Beilstein J. Nanotechnol. 2014, 5, 2363–2373, doi:10.3762/bjnano.5.245
- interactions between proteins in media may occur in a concentration-dependent manner and influence the particle–cell interactions, which is supported by our previous findings on the different aggregation behaviors of particles in biological media. Changes in the release of inflammatory cytokines and cell cycle
Precise quantification of silica and ceria nanoparticle uptake revealed by 3D fluorescence microscopy
Beilstein J. Nanotechnol. 2014, 5, 1616–1624, doi:10.3762/bjnano.5.173
- ., cell-cycle phase dependency, and load capacity), and the number of nanoparticles available for uptake. Conclusion The possibility to quantify nanoparticles on the single-cell level is an important step to better understand the mechanisms of nanoparticles-cell interactions. In this work it was
The softening of human bladder cancer cells happens at an early stage of the malignancy process
Beilstein J. Nanotechnol. 2014, 5, 447–457, doi:10.3762/bjnano.5.52
- their density. The elastic properties of cancerous cells (HTB-9, HT-1376 and T24) were independent of the cell line, the stage of cancer progression, and the cell cycle. Therefore, they underline the usefulness of atomic force microscopy to detect bladder cancer cells because regardless on the state of
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