Beilstein J. Nanotechnol.2012,3, 444–455, doi:10.3762/bjnano.3.51
of hyperthermia with radiation therapy and chemotherapy can greatly improve the efficacy of cancer treatment [30][31]. Ultrasmall magnetic nanoparticles generate heat efficiently in an alternating magnetic field (AMF). Due to their superior properties, such as negligible or low toxicity
be precisely timed. Localized hyperthermia has the potential to work in synergy with chemotherapy, especially because both hyperthermia and the activation of SN38 can be precisely and independently timed. Furthermore, hyperthermia is known to activate the immune system if the correct temperature is
of nanoparticles contained 0.427 mg of iron, indicating that this amount of iron would be high enough for alternating magnetic field hyperthermia in combination with chemotherapy [54]. The MTT assay indicated that 8 pg of iron can be easily loaded in each cell (20% inhibition of cell proliferation
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Scheme 1:
Preparation of core/shell Fe/Fe3O4 magnetic nanoparticles (MNPs).