Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• , China College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China 10.3762/bjnano.10.189 Abstract Diosgenin (Di), a steroidal sapogenin derived from plants, has been shown to exert anticancer effects in preclinical studies. Using Di as a starting material, various Di derivatives were designed

• efficiently than Di phytosomes after 72 h of incubation time by inducing cell cycle arrest and apoptosis. The results indicated that P2Ps could be a promising anticancer formulation for non-small-cell lung cancer. Keywords: diosgenin; non-small-cell lung cancer; phytosomes; sterol structure; Introduction

• Natural products are the most easily accessible source of lead compounds of anticancer drugs [1]. In recent years, chemists have been seeking extensively for effective new chemical entities from natural products and their derivatives. Diosgenin (3β-hydroxy-5-spirostene, Di), is a conventional herbal