Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• delivery systems (DDSs); nanocarriers; quality control (QC); Introduction Nanomaterials Nanomaterials (NMs) have an extensive array of various properties and applications across many industries, including the biomedical, health care, food/agriculture, industrial, environmental, electronic, and renewable

• enhancing therapeutic delivery, particularly in areas such as cancer treatment. This perspective highlights critical considerations in the development of CNM-based nanocarriers, spanning from initial design to clinical implementation. Keywords: carbon nanomaterials (CNMs); carbon nanoparticles (CNPs); drug

Hydrogels and nanogels: effectiveness in dermal applications

• Jéssica da Cruz Ludwig,
• Diana Fortkamp Grigoletto,
• Daniele Fernanda Renzi,
• Wolf-Rainer Abraham,
• Daniel de Paula and
• Najeh Maissar Khalil

Beilstein J. Nanotechnol. 2025, 16, 1216–1233, doi:10.3762/bjnano.16.90

• - Vila Carli, Guarapuava – PR, Brazil Helmholtz-Zentrum für Infektionsforschung, Inhoffenstrasse 7, 38124 Braunschweig, Germany 10.3762/bjnano.16.90 Abstract Drug delivery systems (DDSs) are an important tool for obtaining medicines with improved physicochemical properties, especially for drugs with

• -1950s and 1960s [1][2][3][4]. From the beginning, hydrogels composed of cross-linked acrylic acid were designed to release drugs into the body [5]. 2-Hydroxyethyl methacrylate was one of the first compounds used to build hydrogels as drug delivery systems (DDSs) [6]. Over the past century, hydrogels

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• . While the systemic route of administration with the combination of drug delivery systems (DDSs) to cross the BBB has been promising, the efficiency is often not yet satisfactory [17]. Another noninvasive technique, nose-to-brain delivery or nasal-to-brain delivery (N2B delivery), in contrast, bypasses

Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers

• Ömür Acet,
• Pavel Kirsanov,
• Burcu Önal Acet,
• Inessa Halets-Bui,
• Dzmitry Shcharbin,
• Şeyda Ceylan Cömert and
• Mehmet Odabaşı

Beilstein J. Nanotechnol. 2024, 15, 1189–1196, doi:10.3762/bjnano.15.96

• intended compartment, make thermo- and pH-sensitive polymers a crucial subset of smart polymers in drug delivery systems (DDSs). These responsive platforms must maintain stability at physiological pH levels [21]. Poly(N-isopropylacrylamide) (PNIPAM) stands out as one of the most common and most extensively

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• applications. Biodegradable and bioabsorbable polymers are an excellent choice for a variety of innovative drug delivery systems (DDSs). Biopolymers are also used in cutting-edge scientific applications such as gene expression, tissue engineering, smart drug delivery, and biosensors [11][19]. Modern medicine

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• Makoto Komiyama Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan 10.3762/bjnano.14.21 Abstract Cyclodextrins have been widely employed for drug delivery systems (DDSs) in which drugs are selectively delivered to a

• nanoarchitectures are highly promising for future applications in medicine, pharmaceutics, and other relevant fields. Keywords: cyclodextrin; drug delivery system (DDS); nanoarchitecture; phototherapy; siRNA; Review 1 Introduction Recently, drug delivery systems (DDSs) have been attracting much interest [1][2][3

• developments in nanoarchitectonics, these excellent properties of CyDs have been further extended to the construction of well-designed nanostructures for advanced drug delivery systems (DDSs). In some nanoarchitectures, their physicochemical and biological properties are successfully modulated by using CyDs as