Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• targeted delivery [72]. Patent CN222367609 (2017) describes targeted amphiphilic nanoparticles composed lecithin, procyanidine, and doxorubicin condensated with epigallocatechin gallate in N-hydroxysuccinimide solution, which were developed to inhibit breast cancer. The procyanidine and epigallocatechin

• after 24 h [68]. Similarly, patent CN426774477 (2023) developed an immune checkpoint inhibitor nano-delivery system using natural polyphenols. The formulation contained sulfhydrylated hyaluronic acid (HA-SH), which acts as an adjuvant carrier, and epigallocatechin gallate (EGCG) as an API to form HA

• gallate act as APIs, while lecithin is an excipient. Catechins and their derivatives are natural polyphenolic compounds that are found in foods such as chocolate, red grapes, wine, and apples, as well as especially in green tea from Camellia sinensis (C. sinensis) and C. assumica [120][121]. These

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

• ) (εPLL) (≈4.2 kDa) as a cationic polymer to enhance the delivery of single-strand phosphorothioate backbone ASOs (ASO-GAPDH, ASO-PHD2, and ASO-Luci) through the formation of green nanoparticles (GNPs) with natural polyphenols such as epigallocatechin gallate [65]. The authors demonstrated that εPLL

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• demonstrated the presence of carbonyl groups from polyphenols such as catechin gallate, epicatechin gallate, epigallocatechin, epigallocatechin gallate, gallocatechin gallate, and flavin, amide groups, ethylene systems, and aliphatic amines/alcohols/phenols (polyphenols). Gopu et al. also synthesized AgNPs

Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• had a long-term effect due to the stability of EGCG. The findings of the study underline the potential of antioxidant and antiaging effects of the developed ethosomal formulations for use in the cosmetic field. Keywords: antioxidant effect; antiaging effect; epigallocatechin gallate; ethosomal gel