Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• size (PS), zeta potential (ZP), polydispersity index (PDI), encapsulation efficiency percentage (EE%), and in vitro release. The best ETH formulation was used to prepare the ethosome-based gel (ETHG) by using Carbopol 980 as a gelling agent at a ratio of 1:1 (v/v). The gel formulation was evaluated

• ; ethosome; Introduction Skin aging is the result of biological changes, such as wrinkles, sagging, loss of elasticity, and thickening of the skin and it is caused by intrinsic (occur slowly and vary considerably between populations) and extrinsic factors. The main components of the connective tissue

• use Carbopol 980 as the gelling agent at a ratio of 1:1 (v/v) due to its suitable organoleptic properties, pH value, viscosity, and its ability to homogeneously mix with the ethosome. A transparent, homogeneous, and smooth ethosomal gel system with a skin-compatible pH value (5.60) was obtained (Table