Beilstein J. Nanotechnol.2021,12, 295–303, doi:10.3762/bjnano.12.24
hemoglobin in the supernatant of GNPs-RBCs mixture by monitoring absorbance intensity at 570 nm. The absence of a marked hemotoxicity of this sample is mainly related to the presence of the polymer. The GNR surface had no direct contact with the RBCs because it was completely passivated by the PSS coating
-GNRs for 24 h. (b) A hemotoxicity assay on PSS-GNRs shows that PSS-GNRs are hemo-compatible. No significant difference was seen in the range of 5–500 µg/mL (<20% hemolysis). A low significant (***) of a high significant difference (****) were seen for 1000 and 2000 µg/mL compared with 100 µg/mL. Each
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Figure 1:
(a) TEM image of monodispersed GNRs. (b) Histogram showing the aspect ratio of GNRs. (c) UV–vis abs...
Beilstein J. Nanotechnol.2018,9, 2057–2070, doi:10.3762/bjnano.9.195
a non-toxic amphiphilic calixresorcinarene capable to form nanoconjugates for drug encapsulation, tetraundecylcalixresorcinarene functionalized by methoxy poly(ethylene glycol) chains has been synthesized. The macrocycle obtained is characterized by low hemotoxicity. In aqueous solution it forms
use as a supramolecular drug-delivery system.
Keywords: calixresorcinarene; drug encapsulation; hemotoxicity; methoxy poly(ethylene glycol); temperature-controlled release; Introduction
One of the acute problems of modern medicinal therapy is the development of novel drug-delivery systems with low
calixarene and calixresorcinarene polylactide star polymers [19].
Self-association and hemotoxicity of 3
First, the self-association of macrocycle 3 in the aqueous solution was studied by using small-angle X-ray scattering (SAXS). The obtained data are typical for core–shell particles that practically do not
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Scheme 1:
Synthesis of tetraundecylcalix[4]resorcinarene–mPEG conjugate 3.