Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts

• Sevin Adiguzel,
• Nilay Cicek,
• Zehra Cobandede,
• Feray B. Misirlioglu,
• Hulya Yilmaz and
• Mustafa Culha

Beilstein J. Nanotechnol. 2025, 16, 1068–1081, doi:10.3762/bjnano.16.78

• be sufficient to repair the damage. To address this, the use of piezoelectric nanomaterials (NMs) in bone tissue engineering was investigated. In this study, the influence of the piezoelectric hexagonal boron nitrides (hBNs) and barium titanate (BaTiO3) on human osteoblasts (HOb) was comparatively

• potential to accelerate bone tissue regeneration and promote bone healing. These findings offer a promising avenue for developing new therapies for bone-related injuries and conditions requiring significant bone remodeling. Keywords: bone healing; hexagonal boron nitrides; human osteoblasts; nanomaterials

• hBN. The materials were characterized using spectroscopic, imaging, and thermal techniques, followed by assessment of their piezoelectric properties via piezoresponse force microscopy (PRFM). In vitro studies on human osteoblasts (HOb) under ultrasound (US) exposure examined proliferation, cellular

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• -63 cells, Saos-2 cells, and human osteoblasts, demonstrating its significance in bone tissue engineering [54]. Lemos and colleagues synthesized nanocomposite films comprising chitosan and bioactive glass, as well as a hybrid composition of chitosan and bioactive glass. The chitosan with 20% of

• bioactive glass has a mechanical tensile strength of 67 MPa. In addition, excellent biomineralisation was observed in SBF which shows the ability of bone mineral formation of chitosan nanocomposites [64]. Chitosan and tetraethoxysilane-based aerogels show cell attachment and proliferation of human

• osteoblasts [63]. In another study, Li et al. (2015) used the electrospinning method to fabricate chitosan and MSN-containing nanofibers. In addition, an increase in mechanical strength was observed with an increase in the MSN content. Further in vitro assays reveal that nanofibres slowly degrade and have a

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

The nanomorphology of cell surfaces of adhered osteoblasts

• Christian Voelkner,
• Mirco Wendt,
• Regina Lange,
• Max Ulbrich,
• Martina Gruening,
• Susanne Staehlke,
• Barbara Nebe,
• Ingo Barke and
• Sylvia Speller

Beilstein J. Nanotechnol. 2021, 12, 242–256, doi:10.3762/bjnano.12.20

• applied for studying cell–material interactions [63] with similar characteristics to those of primary human osteoblasts [64][65]. Cells were cultured in Dulbecco’s modified Eagle’s medium (DMEM, 31966-021, Life Technologies Limited, Paisley, UK), with 10% fetal calf serum (FCS, Biochrom FCS Superior

Preparation of micro/nanopatterned gelatins crosslinked with genipin for biocompatible dental implants

• Reika Makita,
• Tsukasa Akasaka,
• Seiichi Tamagawa,
• Yasuhiro Yoshida,
• Saori Miyata,
• Hirofumi Miyaji and
• Tsutomu Sugaya

Beilstein J. Nanotechnol. 2018, 9, 1735–1754, doi:10.3762/bjnano.9.165

• improvement in cell attachment, as a result of the different gelatin surface patterns, was similar to the improvement of cell attachment seen for human osteoblasts and human gingival fibroblasts on gelatin grooves, with a width of 500 nm to 2 µm, created by nanoimprint and thermal crosslinking [55]. In

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• the BNNTs in the primary human osteoblasts (hOBs) under the exposure of low frequency ultrasound (US) [80]. The BNNTs were wrapped with PLL for stabilization in water. Furthermore, they found that the PLL–BNNTs were localized in the cytoplasm in the vesicles. Although the experimental system was