Biocalcite, a multifunctional inorganic polymer: Building block for calcareous sponge spicules and bioseed for the synthesis of calcium phosphate-based bone

• Xiaohong Wang,
• Heinz C. Schröder and
• Werner E. G. Müller

Beilstein J. Nanotechnol. 2014, 5, 610–621, doi:10.3762/bjnano.5.72

• osteoporosis [19]. Recently, we could show in in vitro studies, by using SaOS-2 cells growing in calcium bicarbonate-deprived medium that these cells respond with a significant increase in calcium deposit formation after exposure to bicarbonate [20]. The cells start to form larger crystallite nodules on their

Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating

• Tingjun Lei,
• Alicia Fernandez-Fernandez,
• Romila Manchanda,
• Yen-Chih Huang and
• Anthony J. McGoron

Beilstein J. Nanotechnol. 2014, 5, 313–322, doi:10.3762/bjnano.5.35

• was evaluated by using a Cary WinUV spectrophotometer (Varian/Agilent Technologies, Switzerland). In vitro studies of NPs Cancer cells MES-SA, Dx5, and SKOV3 were purchased from American Type Culture Collection (Manassas, VA) along with McCoy’s 5A medium and fetal bovine serum. Cell culture supplies

• after background subtraction). The ratio R was then determined by normalizing the total pixel intensity of this region of interest to its total area. HT treatment Two different heating modes, namely (1) an incubator and (2) a laser/NP HT delivery system, were used for in vitro studies. Detailed

Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats

• Nadine Haberl,
• Stephanie Hirn,
• Alexander Wenk,
• Jörg Diendorf,
• Matthias Epple,
• Blair D. Johnston,
• Fritz Krombach,
• Wolfgang G. Kreyling and
• Carsten Schleh

Beilstein J. Nanotechnol. 2013, 4, 933–940, doi:10.3762/bjnano.4.105

• be able to cross the air-blood-barrier (ABB), towards circulation, and accumulate in secondary organs [16][17]. Some in vitro studies have demonstrated toxic effects of AgNP on lung cells: In vitro incubation of a rat alveolar macrophage cell line with AgNP induced a concentration- as well as a size

• metabolization of silver ions. Thus, the dissolution of AgNP and release of silver ions as well as the subsequent biochemical transformations are an important issue in AgNP toxicity [27]. However, most of the information available about the mechanisms of AgNP toxicity has been derived from in vitro studies. The

• were not assessed in these studies. Several in vitro studies dealt with the mechanism of cytokine induction after AgNP exposure. Incubation of human mesenchymal stem cells and of peripheral blood monocytes with the same PVP-AgNP that were used in the present study induced a concentration-dependent