Influence of gold, silver and gold–silver alloy nanoparticles on germ cell function and embryo development

• Ulrike Taylor,
• Daniela Tiedemann,
• Christoph Rehbock,
• Wilfried A. Kues,
• Stephan Barcikowski and
• Detlef Rath

Beilstein J. Nanotechnol. 2015, 6, 651–664, doi:10.3762/bjnano.6.66

• driven by oxidation and inflammation [77], it is unclear whether silver in its nanoparticulate form is responsible for the toxic effects, as some studies claim [78], or whether they are solely caused by silver ions dissolving in the course of oxidation of the metal [20]. In our study silver ions proved

• nanoparticles, no abnormal development was observed, except a low-grade inflammation of the embryonic liver after exposure to AgCu alloy nanoparticles. Similar observations were made when administering gold and silver nanoparticles into pregnant mouse and rat dams respectively [44][104]. The reason for the

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

• Anja Ostrowski,
• Daniel Nordmeyer,
• Alexander Boreham,
• Cornelia Holzhausen,
• Lars Mundhenk,
• Christina Graf,
• Martina C. Meinke,
• Annika Vogt,
• Sabrina Hadam,
• Jürgen Lademann,
• Eckart Rühl,
• Ulrike Alexiev and
• Achim D. Gruber

Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25

• reactions directly induced by NP have to be monitored, such as degeneration and necrosis of target structures, NP-induced inflammation with influx and activation of immune cells, tissue fibrosis or even the induction of tumor growth [2][10][11]. Moreover, if the NP are destined for diagnostic or therapeutic

• using optimized contrast setting and thus were able to analyze 243,000 μm3 of liver tissue in a single setting [154]. Furthermore, the image interpretation of TEM is more challenging than that of light microscopic techniques [20][152]. Tissue responses to NP, such as inflammation, fibrosis or necrosis

Oxygen-plasma-modified biomimetic nanofibrous scaffolds for enhanced compatibility of cardiovascular implants

• Anna Maria Pappa,
• Varvara Karagkiozaki,
• Silke Krol,
• Spyros Kassavetis,
• Dimitris Konstantinou,
• Charalampos Pitsalidis,
• Lazaros Tzounis,
• Nikos Pliatsikas and
• Stergios Logothetidis

Beilstein J. Nanotechnol. 2015, 6, 254–262, doi:10.3762/bjnano.6.24

• applied [4][5][6][7]. To date, various sophisticated tissue-engineering structures that mimic the extracellular matrix (ECM) have been proposed, which aim to induce the highly desirable in situ endothelialization of vascular biomaterials while minimizing thrombogenicity and inflammation [8][9][10]. In the

Biocompatibility of cerium dioxide and silicon dioxide nanoparticles with endothelial cells

• Claudia Strobel,
• Martin Förster and
• Ingrid Hilger

Beilstein J. Nanotechnol. 2014, 5, 1795–1807, doi:10.3762/bjnano.5.190

• , it was shown that SiO2 nanoparticles can lead to pulmonary and cardiovascular alterations [12]. After inhalation in rats, they were shown to cause pulmonary inflammation, atrio-ventricular blockage, myocardial ischemic damage, increased blood viscosity [12] or lung fibrogenesis [13]. Moreover, SiO2

• nanoparticles are possible with the consequence of cell death, inflammation and cardiovascular diseases. In this context, there is very little data available on the effects of these nanoparticles related to endothelial cells. Therefore our aim was to clarify the impact of these different environmentally and

• incubation, both investigated CeO2 nanoparticle formulations caused an increase of cytokine release (Figure 4a), particularly of MCP-1 and IL-8, which act as chemo-attractants for monocytes or neutrophils and T lymphocytes during the development of chronic inflammation [41][42]. The IL-6 release after

Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure

• Alicja Panas,
• Andreas Comouth,
• Harald Saathoff,
• Thomas Leisner,
• Marco Al-Rawi,
• Michael Simon,
• Gunnar Seemann,
• Olaf Dössel,
• Sonja Mülhopt,
• Hanns-Rudolf Paur,
• Susanne Fritsch-Decker,
• Carsten Weiss and
• Silvia Diabaté

Beilstein J. Nanotechnol. 2014, 5, 1590–1602, doi:10.3762/bjnano.5.171

• dependent on the exposure method. Keywords: aerosol; air–liquid interface; dose; silica nanoparticles; toxicity; Introduction Amorphous SiO2 nanoparticles (NPs) are regarded as only little pathogenic. However, it has been shown that the inhalation of silica NPs induces transient inflammation in rats [1][2

• selected genes do not indicate major changes in expression within a few hours of cultivation at the ALI [38]. Recently, the concept of “dose rate” as a critical driver of toxicity was again promoted [42]. In animal experiments, instillation of high doses of titania NPs initiates inflammation whereas

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

• Moritz Nazarenus,
• Qian Zhang,
• Mahmoud G. Soliman,
• Pablo del Pino,
• Beatriz Pelaz,
• Susana Carregal-Romero,
• Joanna Rejman,
• Barbara Rothen-Rutishauser,
• Martin J. D. Clift,
• Reinhard Zellner,
• G. Ulrich Nienhaus,
• James B. Delehanty,
• Igor L. Medintz and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1477–1490, doi:10.3762/bjnano.5.161

• clearly can trigger toxic effects in cells such as cytotoxicity, oxidative stress, (pro-)inflammation, and genotoxicity [150][151][152]. While again the detailed mechanisms are very complex and by far not understood in a comprehensive way, yet again there are certain characteristic features [153]. Toxic

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

• Markus Heine,
• Alexander Bartelt,
• Oliver T. Bruns,
• Denise Bargheer,
• Artur Giemsa,
• Barbara Freund,
• Ludger Scheja,
• Christian Waurisch,
• Alexander Eychmüller,
• Rudolph Reimer,
• Horst Weller,
• Peter Nielsen and
• Joerg Heeren

Beilstein J. Nanotechnol. 2014, 5, 1432–1440, doi:10.3762/bjnano.5.155

• : hepatocytes; inflammation; Kupffer cells; liver sinusoidal endothelial cells; nanoparticle toxicity; nanoparticle uptake; quantum dots; superparamagnetic iron-oxide nanocrystals; Introduction The superior optical properties of QDs compared to organic dyes render them promising candidates for the demands of

Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

• Fabian Herzog,
• Kateryna Loza,
• Sandor Balog,
• Martin J. D. Clift,
• Matthias Epple,
• Peter Gehr,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1357–1370, doi:10.3762/bjnano.5.149

• , thus, interpretation of the data needs to be achieved in this regard. Chronic inhalation scenarios need prolonged low-dose applications. Regarding the general view of the performed experiments, no acute cytotoxicity and pro-inflammation activity of Ag NPs can be expected under realistic concentration

Model systems for studying cell adhesion and biomimetic actin networks

• Dorothea Brüggemann,
• Johannes P. Frohnmayer and
• Joachim P. Spatz

Beilstein J. Nanotechnol. 2014, 5, 1193–1202, doi:10.3762/bjnano.5.131

• inflammation, thrombosis, cancer, fibrosis, autoimmune disorders, and infectious diseases [29][30][31]. These discoveries have brought integrins into the focus of pharmacological research for the development of anti-integrin drugs. At least three different integrins have been identified as therapeutic targets

Injection of ligand-free gold and silver nanoparticles into murine embryos does not impact pre-implantation development

• Ulrike Taylor,
• Wiebke Garrels,
• Annette Barchanski,
• Svea Peterson,
• Laszlo Sajti,
• Andrea Lucas-Hahn,
• Lisa Gamrad,
• Ulrich Baulain,
• Sabine Klein,
• Wilfried A. Kues,
• Stephan Barcikowski and
• Detlef Rath

Beilstein J. Nanotechnol. 2014, 5, 677–688, doi:10.3762/bjnano.5.80

• nanoparticles made from gold [26], silver [27][28][29][30], silver–palladium alloy [31], and silver–copper alloy [30] by in ovo injection. Interestingly, no abnormal development was observed, except a low-grade inflammation of the embryonic liver after exposure to AgCu alloy nanoparticles. In mammals, almost

Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats

• Nadine Haberl,
• Stephanie Hirn,
• Alexander Wenk,
• Jörg Diendorf,
• Matthias Epple,
• Blair D. Johnston,
• Fritz Krombach,
• Wolfgang G. Kreyling and
• Carsten Schleh

Beilstein J. Nanotechnol. 2013, 4, 933–940, doi:10.3762/bjnano.4.105

• AgNP can induce moderate pulmonary toxicity, but only at rather high concentrations. Keywords: cytotoxicity; inflammation; pulmonary toxicity; silver nanoparticles; Introduction Silver nanoparticles (AgNP) are among the most promising nanomaterials, and their usage in medical applications and

• increased levels of IL-1, TNF-α, and IL-6 by day 28 after a single instillation [21]. In another mouse study, however, only minimal lung toxicity and inflammation were found after subacute inhalation of AgNP [22]. In addition, there are only two in vivo studies dealing with adverse pulmonary effects of AgNP

• in rats. In these studies, the subchronic inhalation of AgNP caused lung function changes as well as chronic alveolar inflammation and small granulomatous lesions [23][24]. In two other studies from the same group, however, acute and subchronic inhalation of AgNP at lower doses and shorter inhalation