Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

• Dickson Joseph,
• Nisha Tyagi,
• Christian Geckeler and
• Kurt E.Geckeler

Beilstein J. Nanotechnol. 2014, 5, 1452–1462, doi:10.3762/bjnano.5.158

• by different proteins at fixed concentrations is speculated to be due to the degree of internalization of the AuNPs into the cells, which is supported here by the zeta potential studies. The internalization of AuNPs highly depends upon the surface charge of the AuNPs. Thus, the surface charges on the

• acidic pH (which is considered to be the pH in cancer cells) [60] was positive and negative at pH 7 (Figure 5). Hence higher cell internalization takes place in an acidic environment causing greater toxicity compared to neutral pH. The IC50 values of the different protein-coated AuNPs followed the order

• differential effect of AuNPs on the cell viabilities of the fibroblasts and the cancer cell lines. Additional studies, such as cellular uptake and in vivo studies must be conducted to unravel the mechanism involved in the internalization of AuNPs and to understand the anticancer properties of the prepared

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

• Markus Heine,
• Alexander Bartelt,
• Oliver T. Bruns,
• Denise Bargheer,
• Artur Giemsa,
• Barbara Freund,
• Ludger Scheja,
• Christian Waurisch,
• Alexander Eychmüller,
• Rudolph Reimer,
• Horst Weller,
• Peter Nielsen and
• Joerg Heeren

Beilstein J. Nanotechnol. 2014, 5, 1432–1440, doi:10.3762/bjnano.5.155

• that after their internalization nanocrystals are not degraded within 30 min. The storage of oleic acid-coated nanocrystals within these lipophilic, intracellular compartments probably inhibits the release of free iron ions thereby preventing the generation of reactive oxygen species and inflammatory

• intracellular multiprotein oligomer, the so-called-inflammasome [31], which can be activated by intracellular aggregates such as ureate or cholesterol crystals [32]. Notably, hepatic internalization of Ferinject® or SPIOs delivered by polymer or lipid micelles did not influence Il1b gene expression underlining

• ] and therefore it is implausible that this cell type is quantitatively important for lipid micelles internalization. Nevertheless, these specialized macrophages bearing high phagocytic activity are part of the innate immune system [25] and their stimulation can activate the transcription of pro

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• drug concentrations, DOX efficacy was enhanced. The quantitative analysis of DOX release kinetics and cellular internalization are limitations of this study and should be the subject of future studies. Conclusion In this study, a novel targeted drug delivery system consisting of NDs (drug delivery

Injection of ligand-free gold and silver nanoparticles into murine embryos does not impact pre-implantation development

• Ulrike Taylor,
• Wiebke Garrels,
• Annette Barchanski,
• Svea Peterson,
• Laszlo Sajti,
• Andrea Lucas-Hahn,
• Lisa Gamrad,
• Ulrich Baulain,
• Sabine Klein,
• Wilfried A. Kues,
• Stephan Barcikowski and
• Detlef Rath

Beilstein J. Nanotechnol. 2014, 5, 677–688, doi:10.3762/bjnano.5.80

• embryo [14]. However, spontaneous uptake can result into a very heterogeneous nanoparticle load among cells [51] while electroporation of embryos for nanoparticle internalization has not been attempted yet. Therefore, even if the injection of nanoparticles does not actually mirror nanoparticle exposure

Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats

• Nadine Haberl,
• Stephanie Hirn,
• Alexander Wenk,
• Jörg Diendorf,
• Matthias Epple,
• Blair D. Johnston,
• Fritz Krombach,
• Wolfgang G. Kreyling and
• Carsten Schleh

Beilstein J. Nanotechnol. 2013, 4, 933–940, doi:10.3762/bjnano.4.105

• uptake of particles into the cells and a subsequent release of the proinflammatory cytokines IL-6 and IL-8 [30][31]. Moreover, Greulich et al. described the internalization of AgNP to be a clathrin-mediated process [31]. The clathrin-mediated process of internalization after incubation of human

Paper modified with ZnO nanorods – antimicrobial studies

• Mayuree Jaisai,
• Sunandan Baruah and
• Joydeep Dutta

Beilstein J. Nanotechnol. 2012, 3, 684–691, doi:10.3762/bjnano.3.78

• in cellular internalization of ZnO nanoparticles has also been observed by Appierot et al. [6] in a study of their antibacterial effect on E. coli and S. aureus. This work reports on an antimicrobial paper containing zinc oxide (ZnO) nanorods grown by a hydrothermal process, and which can be used for