Beilstein J. Nanotechnol.2024,15, 37–50, doi:10.3762/bjnano.15.4
context, we could observe that the studies failed to correlate consecutive intra-macrophage and intra-amastigote cellular uptake kinetics, once it appears to greatly interfere with the proposed biochemical triggers of Leishmania spp. cell death.
In addition, the work could also summarize that lipid-based
Beilstein J. Nanotechnol.2021,12, 1127–1139, doi:10.3762/bjnano.12.84
imparts multiple benefits – improved IONP stability, enhanced drug coating, higher drug uptake in macrophages at reduced toxicity and slower drug release.
Keywords: drug-nanoparticle interactions; drug uptake; intra-macrophage; iron oxide nanoparticles; norfloxacin; Introduction
Nanoparticles have taken
work, we used NOR as a model fluoroquinolone and a zwitterionic drug, to explore its interaction with IONPs and further achieve any potential improvement in intra-macrophage delivery and drug accumulation. Being a zwitterionic drug, NOR exists in 3 forms; NOR+ (at pH < 6.2), NOR± (at pH 7) and NOR− (at
Information File 1, Figure S6). To enable an intra-macrophage bacterial clearance however, a higher NOR concentration would be required. Therefore, to investigate the use of nanoparticles for the drug delivery in macrophage cells, a NOR concentration that exceeds 8 µg/mL (i.e., 32 µg/mL) was selected. When
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Figure 1:
A representation of the iron oxide nanoparticle synthesis followed by the steps for drug loading. N...