Beilstein J. Nanotechnol.2017,8, 2729–2740, doi:10.3762/bjnano.8.272
chemotherapy for the treatment of peritoneal carcinomatosis. However, recent reports reveal limitations of the currently available technology.
Material and Methods: A novel approach for pressurised intraperitoneal aerosol chemotherapy (PIPAC), called hyperthermic intracavitary nanoaerosol therapy (HINAT
nm) unipolar-charged hyperthermic (41 °C) drug aerosol for quasi uniform drug deposition over the whole peritoneum with significantly deeper drug penetration than that offered by conventional PIPAC.
Keywords: HINAT; intracavitary; intraperitoneal; nanoaerosol; PIPAC; pressurized; therapy
substances at minimal systemic toxicity, first approaches for locoregional/intracavitary chemotherapy (ICC) based on liquid drug instillation (LICC) were already developed about forty years ago [2][3][4]. Unfortunately, the effectivity of LICC is limited by low in-tissue penetration and the difficulties to
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Figure 1:
Schematic illustration of the HINAT approach; CAWS = closed air waste system, HEPA = high efficienc...