Beilstein J. Nanotechnol.2020,11, 866–883, doi:10.3762/bjnano.11.72
the drugs or to use prodrugs. One example of a prodrug is levodopa, a prodrug of dopamine used for the treatment of Parkinson’s disease. However, these options are not always possible depending on the structure of the molecule. Another possibility to increase drug delivery through the BBB is to
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Figure 1:
Blood–brain barrier anatomy. Inspired by [5].
Beilstein J. Nanotechnol.2015,6, 243–253, doi:10.3762/bjnano.6.23
, 43400 UPM Serdang, Selangor, Malaysia 10.3762/bjnano.6.23 Abstract This work explores the potential use of commercially obtained, carboxylated, single-walled carbon nanotubes (SWCNT–COOH) as nanocarriers for the antiparkinson drug, levodopa (LD). The resulting nanohybrid was characterized using
carbon nanotubes; levodopa; MTT assay; nanomedicine; Parkinson’s disease; PC12 cells; sustained release; Introduction
Over the past few years, the revolutionary development of nanomedicine has emerged as one of the most prominent research areas in biomedical science. This interdisciplinary technology is
-(3,4-dihydroxyphenyl)propanoic acid (levodopa) still remains the gold standard for the treatment of PD for symptomatic relief [12]. Now entering into its fourth decade of clinical use, levodopa (LD, the amino acid precursor of dopamine) is the most effective, widely prescribed, oral administered drug
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Figure 1:
FTIR spectra of (A) SWCNT–COOH, (B) LD and (C) SWCNT–LD nanohybrid.