Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

• Gennady L. Burygin,
• Polina I. Abronina,
• Nikita M. Podvalnyy,
• Sergey A. Staroverov,
• Leonid O. Kononov and
• Lev A. Dykman

Beilstein J. Nanotechnol. 2020, 11, 480–493, doi:10.3762/bjnano.11.39

• and evaluate in vivo glyco-gold nanoparticles (glyco-GNPs) bearing the terminal-branched hexaarabinofuranoside fragment (Ara6) of arabinan domains of lipoarabinomannan and arabinogalactan, which are principal polysaccharides of the cell wall of Mycobacterium tuberculosis, the causative agent of

• suggest that glyco-GNPs are promising agents for the generation of anti-mycobacterial antibodies. Keywords: conjugation of glycosides; gold nanoparticles; lipoarabinomannan; Mycobacterium; spacer aglycon; Introduction A number of bacterial glycans [1][2] are specific markers for the detection and the

• ][63]. Although M. tuberculosis has been extensively studied [64], TB presents an ever-growing challenge, and novel strategies for the prevention and treatment of TB are urgently needed [59]. Lipoarabinomannan (LAM) and the related arabinogalactan (AG) are two major structural components of the M