Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• nanoparticulate vaccine is the anti-malarial Mosquirix™ (RTS, S/AS01), recommended by the World Health Organization in four doses for children in 2021. Mosquirix™ employs a liposome-based adjuvant, AS01 (GlaxoSmithKline) [103] that contains 3-O-desacyl-monophosphoryl lipid A and QS-21, a water-soluble triterpene

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• , respectively) and promastigote forms (IC50 values for SNEDDSs A and B, 0.017 and 0.031, respectively). These results evidenced the effectiveness of different SNEDDSs when compared to that of the control AmB-liposome AmBisome, which demonstrated IC50 values 10 times higher for amastigotes and promastigotes [79

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• liposomes (500 mg/kg) could be more efficient than free PZQ treatment. Similar results have been shown in other works that also used liposome with PZQ in different concentrations [50][51][52][53]. In addition, Xie et al. [54] studied the pharmacokinetics of solid lipid nanoparticles composed of castor oil

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• EGCG [8]. In a previous work from our team, an ethosomal formulation developed with rosmarinic acid showed higher inhibition on collagenase and elastase enzymes compared to that of solution and liposome forms. Data supporting the access of ETHs to the deeper layers of the skin were obtained [22

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• estimate that the high levels of BM accumulation for this liposome formulation were probably due to the presence of 20% DSPG in the liposomal bilayer. This yields an overall anionic surface, which is known to have an affinity for the scavenger receptor on BM macrophages. Other polyanions, such as dextran

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• hydrophilic core. Liposomes can thus be loaded with a wide variety of hydrophilic and lipophilic cargos [151]. Some liposome formulations have already received marketing authorizations, such as Ambisome®, Doxil®, Myocet® or more recently Onivyde™. However, no liposomal formulations have received approval for

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

• Mohammad J. Akbar,
• Pâmela C. Lukasewicz Ferreira,
• Melania Giorgetti,
• Leanne Stokes and
• Christopher J. Morris

Beilstein J. Nanotechnol. 2019, 10, 2553–2562, doi:10.3762/bjnano.10.246

• targeting has potential for enhancing drug accumulation in resistant cancer cells. Keywords: bombesin; GRPR; liposome; lung cancer; targeting; Introduction Small-cell lung cancer (SCLC) accounts for approximately one in five lung cancer diagnoses. In spite of global efforts to reduce tobacco smoking in

• the purposes of enhanced liposome delivery to lung cancer. Results and Discussion GRPR as a target in lung cancer The functionality of GRPR in SCLC cells was confirmed by Fura-2 studies in which NCI-H345 or NCI-H82 SCLC cell models were exposed to a dose-range of the canonical GRPR agonist peptide

• those reported for other pegylated liposomes by others [27]. The vesicles were colloidally stable in PBS over 72 h at temperatures of 4, 25 and 37 °C with no significant changes in size, PDI or zeta potential observed (Figure 3a,b). It was noted that the diameter of both liposome formulations was larger

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

• Sebastian Pieper,
• Hannah Onafuye,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Martin Michaelis and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201

• shown to bypass efflux-mediated drug resistance [25]. This included various nanoparticle and liposome formulations of the ABCB1 substrate doxorubicin that were shown to modify the cellular uptake and intracellular distribution of doxorubicin resulting in enhanced effects against ABCB1-expressing cancer

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• analogues have a sterol structure that is very similar to cholesterol. It was reported that Di and lipids formed highly stable complexes at the air–water interface [18]. Therefore, Di and its derivatives could be substituted for cholesterol to form novel stable liposome-like phytosomes. The prepared

• phytosomes were expected to enhance the solubility and bioavailability of the Di derivative for clinical transformation. In this study, we first prepared several Di derivatives and screened the most potent candidate through a preliminary structure–activity relationship study. Then the liposome-like

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells

• Hannah Onafuye,
• Sebastian Pieper,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Klaus Langer and
• Martin Michaelis

Beilstein J. Nanotechnol. 2019, 10, 1707–1715, doi:10.3762/bjnano.10.166

• resistance [6]. This includes various nanoparticle and liposome formulations of the ABCB1 substrate doxorubicin [7][8][9][10][11][12]. Here, we here investigated the effects of doxorubicin-loaded human serum albumin (HSA) nanoparticles in ABCB1-expressing neuroblastoma cells. HSA nanoparticles are easy to

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• suppressor gene delivery. Their results showed that the prepared nanoparticles enhanced the delivery of tumor suppressor genes on U87 and U251 glioma cells [24]. Wang et al. used core–shell nanoparticles for drug and gene co-delivery. They prepared magnetic PLGA/polymeric liposome carriers to achieve

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• between targeting agents and their receptors, such as for example folates and transferrin [7][8]. Additionally, liposomes are also prepared in such a way that simultaneous loading of two drugs into a liposome in order to improve the efficiency of the treatment is possible [9]. Dual drug loading is also

Experiences in supporting the structured collection of cancer nanotechnology data using caNanoLab

• Stephanie A. Morris,
• Sharon Gaheen,
• Michal Lijowski,
• Mervi Heiskanen and
• Juli Klemm

Beilstein J. Nanotechnol. 2015, 6, 1580–1593, doi:10.3762/bjnano.6.161

• . Submitters can enter nanomaterial composition information (Figure 9) including: nanomaterial entities (e.g., dendrimer), functionalizing entities (e.g., small molecule), and chemical associations (e.g., covalent bond). This composition model supports the submission of complex particles (e.g., liposome

Using natural language processing techniques to inform research on nanotechnology

• Nastassja A. Lewinski and
• Bridget T. McInnes

Beilstein J. Nanotechnol. 2015, 6, 1439–1449, doi:10.3762/bjnano.6.149

• trials investigating nano versus non-nano drugs. These include facilitating comparisons between clinical trials testing nano and non-nano drug formulations involving the same active ingredient (e.g., Doxil = pegylated liposome [nano] encapsulated doxorubicin compared to Adriamycin = doxorubicin). In

Fulleropeptide esters as potential self-assembled antioxidants

• Mira S. Bjelaković,
• Tatjana J. Kop,
• Jelena Đorđević and
• Dragana R. Milić

Beilstein J. Nanotechnol. 2015, 6, 1065–1071, doi:10.3762/bjnano.6.107

• antioxidant capacity. The antioxidant activity of 12 fullerene esters (as water soluble fullerosomes, obtained by liposome formation with soybean lecithin [31]) was determined by FOX antioxidant assay [32], using vitamin C and fullerene C60 as reference compounds. The FOX assay is based on the oxidation of

Nanobioarchitectures based on chlorophyll photopigment, artificial lipid bilayers and carbon nanotubes

• Marcela Elisabeta Barbinta-Patrascu,
• Stefan Marian Iordache,
• Ana Maria Iordache,
• Nicoleta Badea and
• Camelia Ungureanu

Beilstein J. Nanotechnol. 2014, 5, 2316–2325, doi:10.3762/bjnano.5.240

• -amino-2,3-dihydro-1,4-phthalazinedione), KH2PO4, Na2HPO4, Tris (tris(hydroxymethyl)aminomethane), HCl, and H2O2were purchased from Merck (Germany). Methanol (99.9%), SWCNTs and the lipids used for the liposome preparation (dipalmitoylphosphatidylcholine, DPPC and cholesterol, Chol) were supplied from

• composition: peptone (Merck, 10 g/L), yeast extract (Biolife, 5 g/L), NaCl (Sigma-Aldrich, 5 g/L) and agar (Fluka, 20 g/L). Synthesis Liposome preparation The hydration method [22] of a thin DPPC film was used to obtain two kinds of multilamellar lipid vesicles (MLVs, 0.5 mM) with and without cholesterol in

• abbreviations used in this work are presented in Table 1. Preparation of the liposome/SWCNT biocomposites Small aliquots of a previously sonicated SWCNT stock suspension (0.9 mg/mL, in PB pH 7.4) were added to a liposome suspension and the resulting mixture was subjected to ultrasound treatment (Hielser

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

• Markus Heine,
• Alexander Bartelt,
• Oliver T. Bruns,
• Denise Bargheer,
• Artur Giemsa,
• Barbara Freund,
• Ludger Scheja,
• Christian Waurisch,
• Alexander Eychmüller,
• Rudolph Reimer,
• Horst Weller,
• Peter Nielsen and
• Joerg Heeren

Beilstein J. Nanotechnol. 2014, 5, 1432–1440, doi:10.3762/bjnano.5.155

• , mice were injected intravenously in the tail vein with 200 µL Clodronate liposome solution (ClodronateLiposomes.org, Amsterdam, Netherland) or empty liposomes as control two days prior to the experiments. Gene expression analysis Gene expression analysis was performed as described [39]. Briefly, total

Model systems for studying cell adhesion and biomimetic actin networks

• Dorothea Brüggemann,
• Johannes P. Frohnmayer and
• Joachim P. Spatz

Beilstein J. Nanotechnol. 2014, 5, 1193–1202, doi:10.3762/bjnano.5.131

• cytoskeletal assembly and membrane targeting. Further research on the influence of talin on lipid membranes was carried out by Takiguchi and co-workers, who studied the effects of adding talin to liposome solutions. They discovered a membrane-breaking function of talin: Lipid membranes were found to open

• , talin can also be a useful tool for controlled manipulation of liposome morphology, which can play an important role in the development of synthetic cells. Since the early 2000’s, research on talin reconstituted in lipid bilayers has not been pursued anymore although many fundamental results on cellular

• ) Nature Publishing Group.) Confocal fluorescence micrographs of giant actin-filled liposomes. Lipid membranes are labelled with rhodamine (red); actin is labelled with AlexaFluor 488 (green). Insets indicate the nature of the actin-membrane interaction. (A) The actin filament solution inside a liposome

Nanoscopic surfactant behavior of the porin MspA in aqueous media

• Ayomi S. Perera,
• Hongwang Wang,
• Tej B. Shrestha,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2013, 4, 278–284, doi:10.3762/bjnano.4.30

• ; hydrophobic interaction; liposome-type cluster; protein cluster; supramolecular; temperature influence; zeta potential; Introduction The homo-octameric porin MspA from Mycobacterium smegmatis is one of the most stable proteins known to date [1]. Due to its size and unique structure [2], its resistance to

• microscopy (TEM). The TEM were prepared by immersing carbon-coated 200-mesh copper grids in aqueous liposome-containing solutions, followed by counter-staining by 2% aqueous uranyl acetate solution, and overnight drying in a desiccator. The dried grids were analyzed by using a HRTEM FEI Tecnai F20 XT Field

Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• tissue have been observed [22]. Liposome encapsulation of SN38 (LE-SN38) enhances the solubility of SN38 and provides protection from rapid drug degradation. Increased cytotoxicity against various tumor cell lines and better therapeutic efficacy in xenograft mouse models, as compared to CPT-11, have been

Microfluidic anodization of aluminum films for the fabrication of nanoporous lipid bilayer support structures

• Jaydeep Bhattacharya,
• Alexandre Kisner,
• Andreas Offenhäusser and
• Bernhard Wolfrum

Beilstein J. Nanotechnol. 2011, 2, 104–109, doi:10.3762/bjnano.2.12

• setup for performing biological experiments without the need to transfer the brittle nanoporous material. We demonstrate this technique by using the same microfluidic system for membrane fabrication and subsequent liposome fusion onto the nanoporous support structure. The resulting bilayer formation is