Protein-based custom-designed molecular nanotraps for biomedical applications

• Devid Maniglio,
• Alice Marinangeli and
• Alessandra Maria Bossi

Beilstein J. Nanotechnol. 2026, 17, 683–687, doi:10.3762/bjnano.17.47

• recognition towards molecular targets of clinical relevance. Envisaged applications span from targeting relevant biomarkers for therapeutics, diagnostics, and in situ sensing to building high-complexity order meta-biomaterials. Keywords: bioMIPs; gelatin methacryloyl (GelMA); meta-biomaterials; molecularly

• property of the biomaterials. For this, bioMIPs fit with the definition of meta-biomaterials. The bioMIPs do not require preserving the protein’s original fold to exert the recognition function; this simplifies manufacturing and hugely reduces costs while still providing effective and high-quality

• molecularly selective meta-biomaterials. This innovative approach opens the way for developing next-generation biocompatible and biointegrable recognition materials, expanding towards nanodevices and nanostructures for targeted molecular recognition in nanomedicine and personalized therapy. The specific