Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• Oviedo, Spain 10.3762/bjnano.16.98 Abstract The rapid spread of antibiotic resistance has intensified the need for novel therapeutic strategies against multidrug-resistant bacterial infections. Metalloantibiotics present a promising alternative in combating resistant pathogens. However, the clinical

• application of metalloantibiotics is limited by their potential toxicity, instability, and lack of target specificity. Encapsulating metalloantibiotics in drug delivery systems, such as liposomes, nanoparticles, and polymeric carriers, could mitigate these challenges, enhancing their therapeutic index and

• .; Liu, G. Nanoscale 2025, 17, 5605–5628. doi:10.1039/D4NR04774E ]. This review explores the potential of encapsulated metalloantibiotics as a new frontier in antimicrobial therapy. We address the mechanisms by which drug delivery systems can stabilize and direct metalloantibiotics to their biological