Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

• Sadaf Mushtaq,
• Khuram Shahzad,
• Tariq Saeed,
• Anwar Ul-Hamid,
• Bilal Haider Abbasi,
• Nafees Ahmad,
• Waqas Khalid,
• Muhammad Atif,
• Zulqurnain Ali and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99

• (MFe2O4, where M = Fe, Co, Ni, or Zn) nanoparticles (NPs) were developed as carriers of the anticancer drugs doxorubicin (DOX) and methotrexate (MTX). Physical characterizations confirmed the formation of pure cubic structures (14–22 nm) with magnetic properties. Drug-loaded NPs exhibited tumor

• studies; magnetic spinel ferrite nanoparticles; methotrexate; poly(isobutylene-alt-maleic anhydride); Introduction Cancer is the second leading cause of death and, as such, it is a global health concern [1]. It is caused by uncontrolled cell proliferation, reduced cell death rate, or both [2

• functionalized with anticancer drugs, such as doxorubicin (DOX) and methotrexate (MTX) via 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) chemistry. The samples were stored at room temperature for further experiments. Our aim was to compare the biocompatibility, colloidal stability, and in vitro

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• range (from 12 to 340 nm) have been found to cross the BBB (Table 1). Gao and Jiang studied the influence of the size of methotrexate-loaded PS80-coated PBCA nanoparticles on their ability to cross the BBB in vivo [130]. Nanoparticles with sizes from 70 to 345 nm were studied. Between 170 and 345 nm, no

• impact of nanoparticle size on the brain delivery of methotrexate could be observed. Only 70 nm nanoparticles showed a slight increase in brain delivery. It has been proven that endocytosis is a size-dependent process and that smaller nanoparticles under 100 nm can be endocytosed more easily by cells