Beilstein J. Nanotechnol.2023,14, 218–232, doi:10.3762/bjnano.14.21
, insulin was orally delivered [98]. N-Acetyl-ʟ-cysteine enhances the mucoadhesion of the drug to enhance its biological absorption, whereas arginine promotes the intestinal absorption of insulin. The composite was sufficiently water-soluble and applicable to the oral delivery of insulin, which is mostly
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Figure 1:
Three essential features of CyDs to construct sophisticated nanoarchitectures for DDS.
Beilstein J. Nanotechnol.2019,10, 2304–2328, doi:10.3762/bjnano.10.222
, The University of Sheffield, Sheffield, UK 10.3762/bjnano.10.222 Abstract Mucoadhesive nanostructured systems comprising poloxamer 407 and Carbopol 974P® have already demonstrated good mucoadhesion, as well as improved mechanical and rheological properties. Curcumin displays excellent biological
gelation temperature of 36 °C, which ensures increased retention after application in the oral cavity. The mucoadhesion results confirmed the previous findings with the nanostructured systems showing a residence time of 20 min in porcine oral mucosa under flow system conditions. Curcumin was released after
selectivity targeting cancer cells.
Keywords: curcumin; mucoadhesion; oral squamous cell carcinoma; permeation; poloxamer 407; Introduction
The development of nanostructured systems containing poloxamer 407 (P407) and Carbopol 974P® (C974P) have previously been shown to have rheological and mechanical
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Figure 1:
Emission spectra of systems containing 0.01% (w/w) P407, 1.6 × 10−4% (w/w) C974P and 1.8 × 10−5 mol...