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Search for "nanocarrier" in Full Text gives 33 result(s) in Beilstein Journal of Nanotechnology.
Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems
Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42
- absorber [20]. In addition, silver (Ag) nanoparticles were synthesized from cotton fabrics and exhibited strong inhibition activity against some bacteria [21]. Recently, pure active pharmaceutical ingredient (API) composed of nanocrystals was investigated, as opposed to drug nanocarrier platforms [22
Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics
Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17
- nowadays, since it enables both diagnosis and therapy at the same time while only using one carrier platform. Therefore, formulating a nanocarrier system that could serve as theragnostic agent by using simple techniques would be an advantage during production. In this project, we aimed to develop a
- nanocarrier that can be loaded with the chemotherapeutic medication chlorambucil and magnetic resonance imaging agents (e.g., iron oxide nanoparticles and near-infrared fluorophore IR780) for theragnostics. Poly(lactic-co-glycolic acid) was combined with the aforementioned ingredients to generate poly(vinyl
Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency
Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7
- been employed to produce nanoformulations of drugs for endowing a better therapeutic effect. The nanoformulations for drug delivery can be designed using nanocarrier systems, including organic materials (liposomes, nanoemulsions, nanomicelles, and nanofibers) and inorganic nanoparticles (gold, silver
- , iron oxide, and mesoporous silica nanoparticles) [4]. Additionally, nanocarrier-free systems, such as drug nanocrystals, are also used to improve the delivery of poorly soluble drugs [5][6]. In our previous study, the saturation concentration of BBR in water was 2.0 mg/mL, while BBR nanoparticles
Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review
Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4
- these carriers with the macrophage membrane. As a result, the macrophages uptake the drug-loaded nanocarrier by phagocytosis, where they will directly act on the parasites [65][66][67]. Several types of nanosystems have been studied for carrying antileishmanial drugs, such as polymeric nanoparticles
Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells
Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100
- marker or drug nanocarrier. Three fluorescent PDA NPs were designed to allow for tracking in three different wavelength ranges by oxidizing BSA/PDA NPs (Ox-BSA/PDA NPs) or labelling with fluorescein 5-isothiocyanate (FITC-BSA/PDA NPs) or rhodamine B isothiocyanate (RhBITC-BSA/PDA NPs). FITC-BSA/PDA NPs
- NPs) but have not been elucidated so far. In contrast to inorganic NPs [23][24], it is unclear whether ONPs can penetrate bacterial cells. Alipour et al. have shown that a 170 nm diameter liposomal nanocarrier increased the accumulation of an antibiotic (polymyxin B) in Gram-negative bacterial cells
- ]. However, the nanocarriers were not found in the bacterial cells, and the question was rarely mentioned at all. Thus, whether the increase in effectiveness of antibiotics carried by NPs is the result of the penetration of the complete nanocarrier–drug system into bacteria or rather an effect of the
Recent progress in cancer cell membrane-based nanoparticles for biomedical applications
Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24
- been applied to treat prostate cancer [56]. This nanoagent shows good drug-loading capacity and photosensitivity and can be applied in NIR photothermal conversion. After the autophagy inhibitor chloroquine (CQ) was loaded onto the nanocarrier, it was coated with prostate cancer cell membrane for tumor
- nanocarrier was encapsulated with a cancer cell membrane, which endowed the NPs with the ability to target tumor tissues and mediate tumor killing through chemical kinetics [83]. In addition, further anticancer effects can be exerted by the ginsenoside Rh2, which was delivered by nanocarriers and inhibited
Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer
Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23
- Pang and co-workers. Clinical studies point to the serious toxicity of conventional application, which might be mitigated with nanotools for co-delivery of therapy for the dual inhibition of VEGF and EGFR pathways. The designed nanocarrier was composed of a polycaprolactone core with bevacizumab and
- )-functionalized nanoporous silica particles loaded with a poly(ʟ-glutamic acid) pH-cleavable linker–doxorubicin conjugate, which self-assembles into NPs after its release from the iNPG [114]. Li et al. designed a multistage nanocarrier for NSCLC targeting, composed of icotinib-loaded amphiphilic chitosan micelles
Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects
Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41
- effective due to its unstable structure and low solubility. In addition, toxicity may occur with an increasing dose [10]. Therefore, overcoming these problems with nanocarrier systems provides significant advantages to researchers. ETHs protect a given compound against environmental factors and also enhance
Use of nanosystems to improve the anticancer effects of curcumin
Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78
- materials for nanomedical applications. Imaging-guided drug delivery of CUR-based nanosystems may also directly target specific cells, thereby increasing the therapeutic and chemopreventive efficacy of this versatile compound. Keywords: nanocarrier; nanoformulations; nanosized delivery systems; phenolic
Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64
- carrier. The imaging applications of these materials will also be discussed. These materials include nanocarrier formulations and nanostructured contrast agents, such as microbubbles (MBs), surfactant-based carriers (including micelles, NEs, and niosomes), polymer-based carriers (including gels
Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management
Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24
- -GNRs at an equivalent DOX concentration of 10 μg/mL (Figure 5). This showed that free DOX was more toxic than DOX conjugated to a nanocarrier at the same drug concentration. Similar findings were reported by other studies [32][33]. The high cytotoxic effect of free DOX is due to the higher availability
- of the drug to the cells after cell uptake. The decreased cytotoxicity of DOX-PSS-GNRs is because of a delayed drug release inside cells [23]. The PSS-GNRs nanocomplex shows potential as biocompatible nanocarrier for drug loading and delivery in cancer therapy. Arunkumar et al. have reported that DOX
- to the presence of the gold nanocarrier. Without laser treatment low drug release from the nanocomplex was observed. Laser-triggered DOX release was measured using the same laser treatment at different time intervals (2, 3, and 4 h) in which drug release was improved in a time-dependent manner. Less
PEG/PEI-functionalized single-walled carbon nanotubes as delivery carriers for doxorubicin: synthesis, characterization, and in vitro evaluation
Beilstein J. Nanotechnol. 2020, 11, 1728–1741, doi:10.3762/bjnano.11.155
- cells per well under standard conditions overnight. After rinsing with PBS, free DOX (DOX solution) or DOX-loaded nanocarrier formulations in fresh serum-free RPMI 1640 medium with 20 μg·mL−1 of DOX were added into each well at 37 °C. After incubation for 12 or 24 h, the medium was removed from the
- free DOX or DOX-loaded nanocarrier formulations was added to replace the medium. After incubation for 12 h, the cells were rinsed with cold PBS for three times and fixed. The nuclei were subsequently stained by Hoechst 33342 for 30 min. A fluorescence microscope (Olympus, Tokyo, Japan) was used to
- detect and observe the fluorescence signal in cells. Further, confocal laser scanning microscopy (CLSM) was utilized to observe the internalization. Cells were seeded into 6-well plates and incubated for 24 h. After co-incubation in 2 mL of medium containing free DOX or DOX-loaded nanocarrier
Key for crossing the BBB with nanoparticles: the rational design
Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72
- and, secondly, angiopep-2 increased the accumulation of nanoparticles in glioma cells thanks to recognition of the LRP1 on the glioma cells surface. Lipid-based nanoparticles Liposomes: Liposomes are well-known and well-studied nanocarrier systems. They are composed of a lipid bilayer surrounding a
- targeting liposomal drug delivery system was then developed by conjugating peptide-22 and c(RGDfK), a ligand of integrin αvβ3 that showed ability to target glioma cells, to liposomes loaded with doxorubicin. This formulation was tested in vivo on an intracranial glioma-bearing mouse model. The nanocarrier
- multitude of nanocarrier systems, such as polymeric, lipid-based or inorganic nanoparticles, have been developed and shown able to cross the BBB owing to their tailored surface properties. In numerous studies, the physical coating of nanoparticles with surfactants and the chemical functionalization with
Luminescent gold nanoclusters for bioimaging applications
Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42
- allowed for plasmonic and magnetic resonance, and luminescence in a single composite system for plasmonic photothermal therapy (PPTT). The bioimaging capability of the plasmonic magneto-luminescent multifunctional nanocarrier (PML-MF) systems were studied in vitro using three types of cancer cells, namely
- ) Schematic representation of the fabrication of the PML-MF nanocarriers and their application in photothermal therapy. B) CLSM images of HeLa, HepG2, A375, and HEK cells treated with the PML-MF nanocarrier for 2 h; images were recorded with a 488 nm excitation laser. C) In vitro magnetic targeting of HeLa
Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery
Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41
- interactions are based on their matching degree and concentration. Thus, the difficulty lies in the availability of these host and guest molecules coupled to charge repulsion between polymers. Encapsulation The formulation of nanocarrier systems is effective only if sufficient encapsulation of molecules can be
Brome mosaic virus-like particles as siRNA nanocarriers for biomedical purposes
Beilstein J. Nanotechnol. 2020, 11, 372–382, doi:10.3762/bjnano.11.28
- protein immunogenicity [46]. Although the PEGylation of CCMV capsids (CCMV-PEG) greatly reduced the immunogenic response, BMV seems to be a better nanocarrier candidate due to its low immunological response. On the other hand, and despite of the immunogenicity of CCMV, which can limit its use for certain
- carry and deliver siRNA into tumor cells has been demonstrated. Cell internalization of the plant viruses, BMV and CCMV, showed no cytotoxicity, making the viruses excellent and biocompatible nanocarrier candidates for targeted molecular anti-cancer therapies. BMV-based nanocarriers showed better
- coupling of drugs and molecular therapies, such as siRNA, in the same nanocarrier seems to be an excellent strategy to increase the efficiency of anti-cancer therapies. Experimental Production and purification of the virus CCMV and BMV were obtained from infected cowpea and barley plants, respectively. The
Phase inversion-based nanoemulsions of medium chain triglyceride as potential drug delivery system for parenteral applications
Beilstein J. Nanotechnol. 2020, 11, 213–224, doi:10.3762/bjnano.11.16
- system with a constant chemical potential and hence a constant osmotic pressure [16]. The aim of this study was to investigate the phase inversion-based production of a lipid nanocarrier without using phospholipids. Thus, instead of solid shelled nanocapsules, flexible nanoemulsions should be formed
Rational design of block copolymer self-assemblies in photodynamic therapy
Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15
- ones such as polyesters or polyacrylates. A second part focuses on important parameters for their design and the improvement of their efficiency. Finally, particular attention has been paid to the question of nanocarrier internalization and interaction with membranes (both biomimetic and cellular), and
- intravenous polymer nanocarrier are biocompatibility, stealthiness, optimal size (20–200 nm), polymer/drug affinity compatible with good encapsulation and release, and a design compatible with the targeted organ [4] (this includes the possible crossing of biological barriers). The aim of this review is to
- , the physical solubilization of the photosensitizer suffers from the risks of leakage from the nanocarrier before the target is reached. Leakage can be prevented when the photosensitizers are covalently linked to the polymer backbone. However, the photosensitizers are mostly inactive in the self
Internalization mechanisms of cell-penetrating peptides
Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10
The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency
Beilstein J. Nanotechnol. 2019, 10, 2594–2608, doi:10.3762/bjnano.10.250
- better understanding of the cell-specific binding and trafficking event for a prediction of the therapeutic efficacy of a nanocarrier. A) Size distribution of chitosan/HA nanoparticles (1 mg/mL, deionized water) prepared from 35 (top) and 650 (bottom) kDa chitosan using a templated (dashed lines) or
Frontiers in pharmaceutical nanotechnology
Beilstein J. Nanotechnol. 2019, 10, 2538–2540, doi:10.3762/bjnano.10.244
- applied in the development of semisolids. But we still have much to learn. Pharmaceutical science has indisputably become more complex with the discovery of nanocarrier-based delivery systems. Fueled by first successes in the 1990s, liposomes were at the forefront of cancer therapy [12][13]. The
- the intertwined processes involved in biodistribution of deposition of nanocarrier delivery will finally lead to a broader acceptance, and consequently, to successful translation from bench to bedside. Matthias G. Wacker Singapore, November 2019 Acknowledgements The author acknowledges Prof. Jörg
Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration
Beilstein J. Nanotechnol. 2019, 10, 2280–2293, doi:10.3762/bjnano.10.220
- curcumin into PLGA NPs using different techniques Finally, after evaluating the parameters which are relevant to have an influence on the colloidal properties, the incorporation of the drug into the nanocarrier was addressed. The goal was to compare the encapsulation efficiency of curcumin into PLGA NPs
Targeting strategies for improving the efficacy of nanomedicine in oncology
Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16
- receptors expressed in tumoral but also in healthy cells, and the rapid uptake by the reticuloendothelial system, macrophages and supportive cells such as fibroblasts the decrease the nanocarrier concentration in the blood stream. Also, the poor penetration capacity into the tumoral mass due to strong
- cellular targeting systems for a better performance. The strategies for providing multiple targeting abilities within one single nanocarrier will be discussed in the following section. Simultaneous targeting of tissue and cells Double vectorization has been proposed in the last years as an approach to
- overcome some of the physical barriers in nanomedicine. The combination of tissular and cellular targeting agents in a unique nanocarrier may improve accumulation and/or the uptake in cancer cells without affecting healthy cells. Firstly, the simplest approach is to randomly attach both tissular and
Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules
Beilstein J. Nanotechnol. 2018, 9, 1328–1338, doi:10.3762/bjnano.9.126
- using AutoDock tools (ADT) [48]. The orientation of polymer chains obtained from the above MD simulations was used to carry out the docking calculations. Due to the fact that the polymer core is the protective portion for drugs in this kind of nanocarrier [31], only the PLA core was considered for
- the surface of the NP, interacting with the terminal groups of lipid chains (for example through electrostatic interactions) or with the solvent, and thus, the protective function of the nanocarrier would be revoked. However, significant differences in experimental results (drug loading) have been
Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells
Beilstein J. Nanotechnol. 2018, 9, 321–332, doi:10.3762/bjnano.9.32
- almost twice as much QDs compared with MCF7 cells (Figure 6F–H). Thus, we demonstrated that nanoengineered MSCs could be a tool for targeting metastatic breast cancer cells. It has been reported that metastatic breast cancer cells demonstrate higher nanocarrier uptake efficiency than MCF7 due to the
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