Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors

• Joyita Roy and
• Kunal Roy

Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27

• well as in biological systems. Since the cell membrane is negatively charged, the interaction between NPs and cell membrane or organelles can be highly influenced by the zeta potential. There is an increased interest in integrating data on metal oxides in the field of nanotoxicology that would be able

New trends in nanobiotechnology

• Pau-Loke Show,
• Kit Wayne Chew,
• Wee-Jun Ong,
• Sunita Varjani and
• Joon Ching Juan

Beilstein J. Nanotechnol. 2023, 14, 377–379, doi:10.3762/bjnano.14.32

• such as nanomaterials applied in biotechnology; nanoparticles used in environmental science and technology; nanosensors used in biosystems; nanomedicine in the context of biochemical engineering; micro- and nanofluidics; micro- and nano-electromechanical systems; nanoscience and nanotoxicology

Identifying diverse metal oxide nanomaterials with lethal effects on embryonic zebrafish using machine learning

• Richard Liam Marchese Robinson,
• Haralambos Sarimveis,
• Philip Doganis,
• Xiaodong Jia,
• Marianna Kotzabasaki,
• Christiana Gousiadou,
• Stacey Lynn Harper and
• Terry Wilkins

Beilstein J. Nanotechnol. 2021, 12, 1297–1325, doi:10.3762/bjnano.12.97

• , the most appropriate dose units to characterise the differential hazard of different ENMs, remains an area under active consideration in the nanotoxicology community [65][77][78]. Whilst applied surface area or particle number doses might be more appropriate [78], albeit this is not accepted in all

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

• Jaison Jeevanandam,
• Ahmed Barhoum,
• Yen S. Chan,
• Alain Dufresne and
• Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98

Bright fluorescent silica-nanoparticle probes for high-resolution STED and confocal microscopy

• Isabella Tavernaro,
• Christian Cavelius,
• Henrike Peuschel and
• Annette Kraegeloh

Beilstein J. Nanotechnol. 2017, 8, 1283–1296, doi:10.3762/bjnano.8.130

• components and structures are not only important in the nanomedical field but also in nanotoxicology. Due to the fact that more and more nano-based materials come to market and are developed for everyday use, the latter discipline is targeting the effects of engineered nanomaterials on living organisms [15

An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology

• Richard L. Marchese Robinson,
• Mark T. D. Cronin,
• Andrea-Nicole Richarz and
• Robert Rallo

Beilstein J. Nanotechnol. 2015, 6, 1978–1999, doi:10.3762/bjnano.6.202

• Rovira i Virgili, Av. Paisos Catalans 26, 43007 Tarragona, Catalunya, Spain 10.3762/bjnano.6.202 Abstract Analysis of trends in nanotoxicology data and the development of data driven models for nanotoxicity is facilitated by the reporting of data using a standardised electronic format. ISA-TAB-Nano has

• associated with the use of ISA-TAB-Nano and presents a set of resources designed to facilitate the manual creation of ISA-TAB-Nano datasets from the nanotoxicology literature. These resources were developed within the context of the NanoPUZZLES EU project and include data collection templates, corresponding

• weaknesses of the resources are discussed along with possible future developments. Keywords: databases; ISA-TAB-Nano; nanoinformatics; nanotoxicology; quantitative structure–activity relationship (QSAR); Introduction Nanotechnology, which may be considered the design and application of engineered

NanoE-Tox: New and in-depth database concerning ecotoxicity of nanomaterials

• Katre Juganson,
• Angela Ivask,
• Irina Blinova,
• Monika Mortimer and
• Anne Kahru

Beilstein J. Nanotechnol. 2015, 6, 1788–1804, doi:10.3762/bjnano.6.183

• nanotoxicology by 2005 and the ‘pioneering’ NPs in environmental safety studies were CNTs, fullerenes, TiO2, SiO2 and ZnO. The analysis of the journals that contributed to the database revealed that more than half of the relevant papers originated from seven journals: Environmental Toxicology and Chemistry (29

Using natural language processing techniques to inform research on nanotechnology

• Nastassja A. Lewinski and
• Bridget T. McInnes

Beilstein J. Nanotechnol. 2015, 6, 1439–1449, doi:10.3762/bjnano.6.149

• Nanotoxicity Searcher is a tool to automatically annotate nanomedicine and nanotoxicology literature using pattern matching techniques [9][16][33]. The group used ABNER (available at http://pages.cs.wisc.edu/~bsettles/abner/), a biomedical named entity recognizer, to identify names of nanomaterials (NANO

• between nanotoxicology and nanoinformatics researchers will provide interpretive context so that computer understandable patterns can be developed to enable future knowledge discovery from the literature. Recommendations There is a critical need to automatically extract and synthesize knowledge and trends

Influence of gold, silver and gold–silver alloy nanoparticles on germ cell function and embryo development

• Ulrike Taylor,
• Daniela Tiedemann,
• Christoph Rehbock,
• Wilfried A. Kues,
• Stephan Barcikowski and
• Detlef Rath

Beilstein J. Nanotechnol. 2015, 6, 651–664, doi:10.3762/bjnano.6.66

• articles per year were published concerning nanotoxicology in general, only 3 of them concerned spermatozoa and 2 oocytes (source: web of knowledge). We are therefore unable to draw a comprehensive picture of nanoparticle reprotoxicology. However, studies concerning gold (AuNP) and silver nanoparticles

• oocytes represent a very sensitive system for the exploration of nanotoxicology in which even subtle effects can be visualized. The use of this test system should be increased in the future to gain a better understanding of possible influences of nanoparticle exposure on female reproduction. Effect of

• nanotoxicology on reproductive cells provides an ideal tool. Schematic representation of experiments conducted within the collaboration project REPROTOX. (A) Exemplary AuAg colloids with different molar fractions. (B) Correlation of gold molar fraction with the maximum surface plasmon resonance extinction peak

Biological responses to nanoscale particles

• Reinhard Zellner

Beilstein J. Nanotechnol. 2015, 6, 380–382, doi:10.3762/bjnano.6.37

• and translocation between cells are important processes which affect not only nanotoxicology but also nano-biomedicine. In the SPP1313, several projects presented experimental strategies to study and dissect nanoparticle uptake. The employed approaches comprised not only technical advancements such as

The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice

• Denise Bargheer,
• Artur Giemsa,
• Barbara Freund,
• Markus Heine,
• Christian Waurisch,
• Gordon M. Stachowski,
• Stephen G. Hickey,
• Alexander Eychmüller,
• Jörg Heeren and
• Peter Nielsen

Beilstein J. Nanotechnol. 2015, 6, 111–123, doi:10.3762/bjnano.6.11

• elegantly used to study the absorption of intact nanoparticles from the gastrointestinal tract, an important topic in nanotoxicology. For this, 59Fe-labeled SPIOs were given by gavage to groups of mice and the 59Fe-WBR was followed in living mice for 14 d using a whole body counter (Figure 5A). Most of the

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices

• Stephanie Hirn,
• Nadine Haberl,
• Kateryna Loza,
• Matthias Epple,
• Wolfgang G. Kreyling,
• Barbara Rothen-Rutishauser,
• Markus Rehberg and
• Fritz Krombach

Beilstein J. Nanotechnol. 2014, 5, 2440–2449, doi:10.3762/bjnano.5.253

• Papeterie CP 209, 1723 Marly, Switzerland 10.3762/bjnano.5.253 Abstract Precision-cut lung slices (PCLS) are an established ex vivo alternative to in vivo experiments in pharmacotoxicology. The aim of this study was to evaluate the potential of PCLS as a tool in nanotoxicology studies. Silver (Ag-NPs) and

• deeper regions, indicating that the majority of the particles did not have the chance to interact with all cells present in the tissue slice. In conclusion, our findings suggest that PCLS may have some limitations when used for nanotoxicology studies. To strengthen this conclusion, however, other NP

• commercial ENPs is missing so far as there is no regulation for the fabrication and declaration of ENPs in consumer products. Assigned with the task to determine potential health risk effects of ENPs, nanotoxicology is a rapidly emerging research area [1]. There are several in vitro and in vivo models for

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

• Sebastian Ahlberg,
• Alexandra Antonopulos,
• Jörg Diendorf,
• Ralf Dringen,
• Matthias Epple,
• Rebekka Flöck,
• Wolfgang Goedecke,
• Christina Graf,
• Nadine Haberl,
• Jens Helmlinger,
• Fabian Herzog,
• Frederike Heuer,
• Stephanie Hirn,
• Christian Johannes,
• Stefanie Kittler,
• Manfred Köller,
• Katrin Korn,
• Wolfgang G. Kreyling,
• Fritz Krombach,
• Jürgen Lademann,
• Kateryna Loza,
• Eva M. Luther,
• Marcelina Malissek,
• Martina C. Meinke,
• Daniel Nordmeyer,
• Anne Pailliart,
• Jörg Raabe,
• Fiorenza Rancan,
• Barbara Rothen-Rutishauser,
• Eckart Rühl,
• Carsten Schleh,
• Andreas Seibel,
• Christina Sengstock,
• Lennart Treuel,
• Annika Vogt,
• Katrin Weber and
• Reinhard Zellner

Beilstein J. Nanotechnol. 2014, 5, 1944–1965, doi:10.3762/bjnano.5.205

• with silver nanoparticles. Keywords: aerosols; biological properties; cell biology; nanoparticles; nanotoxicology; silver; Review Introduction Silver in the form of ions and nanoparticles is extensively used in consumer products and medical devices [1][2][3][4][5][6][7][8][9][10][11]. This is due to

Biocompatibility of cerium dioxide and silicon dioxide nanoparticles with endothelial cells

• Claudia Strobel,
• Martin Förster and
• Ingrid Hilger

Beilstein J. Nanotechnol. 2014, 5, 1795–1807, doi:10.3762/bjnano.5.190

• nanoparticles: 100 µg/mL; SiO2 nanoparticles: 10 µg/mL). Keywords: cerium dioxide; endothelial cells; nanoparticle; nanotoxicology; silicon dioxide; Introduction Nowadays, a large variety of nanoparticles are being produced for different applications. These include the industrially and environmentally highly

The surface properties of nanoparticles determine the agglomeration state and the size of the particles under physiological conditions

• Christoph Bantz,
• Olga Koshkina,
• Thomas Lang,
• Hans-Joachim Galla,
• C. James Kirkpatrick,
• Roland H. Stauber and
• Michael Maskos

Beilstein J. Nanotechnol. 2014, 5, 1774–1786, doi:10.3762/bjnano.5.188

• nanoparticles are already widely investigated. Therefore, they are an ideal reference system to demonstrate the potential of the combination of characterization techniques that we have chosen. Parts of the characterization data acquired within this study were also used as the basis for nanotoxicology studies

• [51]. As reported there, NexSil20 is a commercially available, colloidal silica without surface modification. Keeping in mind its application to nanotoxicology studies, this system was chosen due to the fact that colloidal silica is used for most real life applications of silica nanoparticles. Poly

• nanotoxicology research: the investigation of the interaction of nanoparticles with the components of the alveolar surfactant film [71][72][73]. As the lung surfactant is the first barrier that inhaled nanoparticles encounter after passing the respiratory tract [74], interactions with this barrier are crucial in

Precise quantification of silica and ceria nanoparticle uptake revealed by 3D fluorescence microscopy

• Adriano A. Torrano and
• Christoph Bräuchle

Beilstein J. Nanotechnol. 2014, 5, 1616–1624, doi:10.3762/bjnano.5.173

• unusual uptake behavior could be cell division. Keywords: ceria nanoparticles; fluorescence microscopy; image analysis; nanotoxicology; silica nanoparticles; Introduction Measuring the interaction between nanoparticles and cells is a mandatory step for the investigation of nanoparticles designed for

Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure

• Alicja Panas,
• Andreas Comouth,
• Harald Saathoff,
• Thomas Leisner,
• Marco Al-Rawi,
• Michael Simon,
• Gunnar Seemann,
• Olaf Dössel,
• Sonja Mülhopt,
• Hanns-Rudolf Paur,
• Susanne Fritsch-Decker,
• Carsten Weiss and
• Silvia Diabaté

Beilstein J. Nanotechnol. 2014, 5, 1590–1602, doi:10.3762/bjnano.5.171

• by a linear function of the applied particle mass. For the cell exposures a mean mass dose of (117 ± 46) µg·cm−2 follows from this function. This is within the dose range of classical nanotoxicology studies under submerged conditions and beyond the lowest observed adverse effect level (LOAEL) defined

The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

• Dominic Docter,
• Christoph Bantz,
• Dana Westmeier,
• Hajo J. Galla,
• Qiangbin Wang,
• James C. Kirkpatrick,
• Peter Nielsen,
• Michael Maskos and
• Roland H. Stauber

Beilstein J. Nanotechnol. 2014, 5, 1380–1392, doi:10.3762/bjnano.5.151

• applications of nanoparticles (NP). Biological responses to NP, including nanotoxicology, are caused by the interaction of the NP with cellular membranes and/or cellular entry. Here, the physico-chemical characteristics of NP are widely discussed as critical determinants, albeit the exact mechanisms remain to

• intense investigations, current knowledge of the physiological effects of nanoparticles on biological barriers and the underlying molecular mechanisms is still fragmented [6][7][8]. The main purpose in the field of nanotoxicology is to address potential adverse health effects induced by such novel