Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure

• Giovanni N. Roviello,
• Domenica Musumeci,
• Valentina Roviello,
• Marina Pirtskhalava,
• Alexander Egoyan and
• Merab Mirtskhulava

Beilstein J. Nanotechnol. 2015, 6, 1338–1347, doi:10.3762/bjnano.6.138

• innovative biomedical strategies mainly in the field of anticancer therapy. Keywords: nucleopeptides; poly(rA) binders; RNA; self-structures; Review Polyadenylation in RNA processing Polyadenylation is part of the RNA processing pathway that leads to the production of mature mRNA molecules (Figure 1) [1

• molecules but also by interaction with nucleopeptides, metal–amino acid complexes, nanotubes, etc. Indeed, from a structural point of view, numerous studies were conducted in the last forty years describing in detail the properties of poly(rA) and its complexes with various molecules, such as DNA

• glucosides; others are artificial, as in the case of proflavine, 4',6-diamidino-2-phenylindole dihydrochloride (DAPI), azacyanines, nucleopeptides, benzodifurans, nanotubes and metal–amino acid complexes. Poly(rA) binders of natural origin and their synthetic derivatives Alkaloids Isoquinoline alkaloids