Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

• , where drug delivery is limited by the blood–pancreas barrier. The nanoparticles successfully crossed the barrier, accumulated selectively in pancreatic cancer cells, inhibited tumor growth and its metastasis to the liver [36]. Similarly, neutrophil membrane-coated PLGA nanoparticles were used for the

• chemotherapeutic efficacy. In this respect, Wang et al. synthesized bioengineered cancer cell membrane-coated, gemcitabine-loaded PLGA dual targeting NPs (PG@KMCM) for pancreatic cancer treatment. The PG@KMCM efficiently delivered gemcitabine to pancreatic cancer cells and TAMs simultaneously and potentiated the

Identification of structural features of surface modifiers in engineered nanostructured metal oxides regarding cell uptake through ML-based classification

• Indrasis Dasgupta,
• Totan Das,
• Biplab Das and
• Shovanlal Gayen

Beilstein J. Nanotechnol. 2024, 15, 909–924, doi:10.3762/bjnano.15.75

• significantly contribute to the cellular uptake of ENMOs in multiple cell types, including pancreatic cancer cells (PaCa2), human endothelial cells (HUVEC), and human macrophage cells (U937). The best models have been identified for each cell type and analyzed to detect the structural fingerprints/features

Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy

• Xiaoteng Liang,
• Shuai Liu,
• Xiuchao Wang,
• Dan Xia and
• Qiang Li

Beilstein J. Nanotechnol. 2021, 12, 1372–1379, doi:10.3762/bjnano.12.101

• regulation of cell activity, and hence to the health level of organisms. Here, the morphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2, BxPC-3) were studied by atomic force microscopy. In addition, the mechanical properties of MIA PaCa-2

• properties; pancreatic cancer cells; Introduction Pancreatic cancer is a highly malignant tumor [1] with the highest mortality rate (ca. 100%) and the lowest 5-year survival rate (≤5%) when all stages are combined [2][3]. Since no significant symptoms appear until the late stage of pancreatic cancer, the

• ultrastructure of living cells [15][16], cell membranes, membrane proteins [17][18] and DNA [19], and through recording single molecular force spectra [20][21]. However, the morphology and the nanoscale mechanical properties of malignant pancreatic cancer cells (PCCs) under anticancer drug treatment have not

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• ), where a reduced cell proliferation was consequently obtained [135]. In another study, CUR-loaded MNP were significantly more effective in reducing tumor size (71.2%) in xenotransplanted mice (HPAF-II pancreatic cancer cells), as compared to F-CUR (35.9%). This suggests the need to take into account more